Our Science – Bai Website
Yawen Bai, Ph.D.
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| A Foldon Model of Protein Folding |
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| We developed a native-state hydrogen exchange method to identify partially unfolded intermediate states, which have high free energy and low population (Bai et al., Science, 1995). We also developed a native-state hydrogen exchange-guided protein engineering method to populate the intermediates for structural determination at atomic resolution by NMR (Feng et al., PNAS, 2005). |
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| Structures of Histone Variant Chaperones in Complex with the Histones |
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| We determined the structures of the chaperones (Chz1 and Scm3) in complex with the corresponding histone variants H2A.Z-H2B (Zhou et al., Nat. Struct. Mol. Biol.2008) and Cse4-H4 (Zhou et al., Nature, 2011). |
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| Structural Models of Nucleosome in Complex with Chromatin Factors Determined by Methyl-Based NMR |
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| We have assigned the methyl groups in the nucleosome and built a structural model of the nucleosome in complex with high mobility group nucleosomal protein 2 (HMGN2) (Kato et al., PNAS, 2011). |
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| Current group memebrs |
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| Former group members |
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This page was last updated on 4/3/2012.
