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Yawen Bai, Ph.D.

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A Foldon Model of Protein Folding
A Foldon Model of Protein Folding
We developed a native-state hydrogen exchange method to identify partially unfolded intermediate states, which have high free energy and low population (Bai et al., Science, 1995). We also developed a native-state hydrogen exchange-guided protein engineering method to populate the intermediates for structural determination at atomic resolution by NMR (Feng et al., PNAS, 2005).
Structures of Histone Variant Chaperones in Complex with the Histones
Structures of Histone Variant Chaperones in Complex with the Histones
We determined the structures of the chaperones (Chz1 and Scm3) in complex with the corresponding histone variants H2A.Z-H2B (Zhou et al., Nat. Struct. Mol. Biol.2008) and Cse4-H4 (Zhou et al., Nature, 2011).
Structural Models of Nucleosome in Complex with Chromatin Factors Determined by Methyl-Based NMR
Structural Models of Nucleosome in Complex with Chromatin Factors Determined by Methyl-Based NMR
We have assigned the methyl groups in the nucleosome and built a structural model of the nucleosome in complex with high mobility group nucleosomal protein 2 (HMGN2) (Kato et al., PNAS, 2011).
Current group memebrs
Current group memebrs
Former group members
Former group members

This page was last updated on 4/3/2012.