Our Science – Casellas Website
Rafael Casellas, Ph.D.
|Post-germinal center plasma cells permanently labeled with the yellow fluorescent protein (YFP)|
|Longitudinal section of a villus from the small intestine of AID-CRE-YFP transgenic mice. In these animals,
B cells recognizing bacterial antigens in the gut express the AID hypermutase enzyme and become
permanently tagged with the yellow fluorescent protein. The progeny of these activated B cells home to the
intestinal villi as plasma cells (green in the picture) and secrete large amounts of IgA, which precludes
attachment of bacteria and toxins to the intestinal epithelium. Cell nuclei were stained with DAPI (blue) and
actin was labeled with phalloidin (red).
Image collected by Kristen Zaal on the Leica SP5 Confocal Microscope at the Light Imaging Section, NIAMS
This page was last updated on 3/8/2011.