Wiem Lassoued, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- 10/7N258
- Bethesda, MD 20892
- 301-898-6351
- wiem.lassoued@nih.gov
RESEARCH SUMMARY
Dr. Lassoued is Head of the Tumor Immune-Micro-Environment (TIME) laboratory at the Center for Immuno-Oncology. She received her Ph.D. in 2012 through a collaboration program for outstanding students between the University of Sciences (Tunisia) and the University of Pennsylvania (USA).
The focus of the TIME group is to study and comprehend the heterogeneity and multiplicity of the TIME in cancer tissues, and the impact of immune-based therapies on the spatial distribution and complex interplay between tumor cells and their surrounding immune cells in clinical samples. These studies help our understanding of the mechanisms of resistance to immune-based therapies and help identify innovative immuno-therapeutic methods as single agents or in combination.
Dr. Lassoued and her group use multiplex immunofluorescence and multispectral imaging on formalin-fixed paraffin-embedded tissue. They develop multiplex panels of biomarkers to identify phenotypically and functionally different components of TIME including tumor cells, immune cells, fibroblasts, etc. They use in situ hybridization to assess the expression of growth factors and cytokines that are the main mediators of intercellular communication in the immune system.