Protein-Nucleic Acid Interaction Section
- Solution NMR spectroscopy
My group shares four multi-channel spectrometers (Varian Innova plus 500, 600 and
800 MHz, and a Bruker Ultrashield Plus) with Dr. R. Andrew Byrdâ€™s group. All of
Varian spectrometers are equipped with cryo-probes.
- Small-angle scattering
We apply solution scattering techniques, in combination with solution NMR spectroscopy,
to study structures of large proteins and RNAs in solution.
- Other biophysical tools
We routinely utilize an array of biophysical tools, available within the Structural
Biophysics Laboratory and the Frederick National Lab campus whenever necessary. These tools
include but not limited to mass spec, calorimeters, light scattering, ultra-centrifugation,
conforcal fluorescence microscopy, EM, CD and various UV- and IR spectrometers.
- Biochemistry bench
My lab is equipped to perform structural biology study of both proteins and nucleic
acids. These include cloning, protein and RNA preparation, purification and characterization.
We also have full access to a tissue and cell culture facility within the building.