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Structural Biophysics Laboratory (SBL)
Protein-Nucleic Acid Interaction Section

Experimental Approach

  1. Solution NMR spectroscopy
    My group shares four multi-channel spectrometers (Varian Innova plus 500, 600 and 800 MHz, and a Bruker Ultrashield Plus) with Dr. R. Andrew Byrd’s group. All of Varian spectrometers are equipped with cryo-probes.
  2. Small-angle scattering
    We apply solution scattering techniques, in combination with solution NMR spectroscopy, to study structures of large proteins and RNAs in solution.
  3. Other biophysical tools
    We routinely utilize an array of biophysical tools, available within the Structural Biophysics Laboratory and the Frederick National Lab campus whenever necessary. These tools include but not limited to mass spec, calorimeters, light scattering, ultra-centrifugation, conforcal fluorescence microscopy, EM, CD and various UV- and IR spectrometers.
  4. Biochemistry bench
    My lab is equipped to perform structural biology study of both proteins and nucleic acids. These include cloning, protein and RNA preparation, purification and characterization. We also have full access to a tissue and cell culture facility within the building.
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