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Structural Biophysics Laboratory (SBL)
Macromolecular NMR Section

NMR Methodology

Our group believes strongly in the continuing development of NMR techniques to solve the biological problems we study. Group members become well trained in the fundamentals of NMR spectroscopy and stay abreast of the latest tools in the field. Adaptation or development of new perspectives is pursued when existing tools are insufficient to solve the problems. Examples of this are our work in the use of long-range restraints from pseudocontact shifts using metal tagging reagents, the use of paramagnetic relaxation restraints, and the use of SAXS to complement our solution NMR studies. The SAXS work is done via our close interactions with the group of Yun-Xing Wang. Please refer to the PNAI section of our website for further information on the use and development of SAXS methodology.


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