Dr. Larry Keefer

Dr. Larry Keefer
Drug Design
301-846-1467

Research Summary

Link to Diazeniumdiolate Chemistry Database

Nitric oxide (NO) is a potent and multifaceted bioregulatory agent. This project is aimed at finding ways to target NO to specific sites in the body for important research and/or therapeutic applications. Our strategy in pursuing this goal is to begin by characterizing the fundamental chemistry of the NO-releasing diazeniumdiolates (compounds containing the [N(O)NO] functional group). We then attempt to exploit our accumulating knowledge in this area as a platform for solving problems in biomedical research and clinical medicine. We are currently pursuing basic research investigations into the structure, spectra, dissociation to NO and/or HNO, alkylation, arylation

PublicationsPatents

1 - 5 of 231 results

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1) Weidensteiner C, Reichardt W, Shami PJ, Saavedra JE, Keefer LK, Baumer B, Werres A, Jasinski R, Osterberg N, Weyerbrock A.
Effects of the nitric oxide donor JS-K on the blood-tumor barrier and on orthotopic U87 rat gliomas assessed by MRI.
Nitric Oxide. 30C: 17-25, 2013. [Journal]

2) Fuhrman BJ, Pfeiffer RM, Wu AH, Xu X, Keefer LK, Veenstra TD, Ziegler RG.
Green tea intake is associated with urinary estrogen profiles in Japanese-American women.
Nutr J. 12: 25, 2013. [Journal]

3) Holland RJ, Maciag AE, Kumar V, Shi L, Saavedra JE, Prud'homme RK, Chakrapani H, Keefer LK.
Cross-Linking Protein Glutathionylation Mediated by O(2)-Arylated Bis-Diazeniumdiolate 'Double JS-K'.
Chem. Res. Toxicol. 25: 2670-7, 2012. [Journal]

4) Nandurdikar RS, Maciag AE, Cao Z, Keefer LK, Saavedra JE.
Diazeniumdiolated carbamates: a novel class of nitric oxide donors.
Bioorg. Med. Chem. 20: 2025-9, 2012. [Journal]

5) Fuhrman BJ, Schairer C, Gail MH, Boyd-Morin J, Xu X, Sue LY, Buys SS, Isaacs C, Keefer LK, Veenstra TD, Berg CD, Hoover RN, Ziegler RG.
Estrogen metabolism and risk of breast cancer in postmenopausal women.
J. Natl. Cancer Inst. 104: 326-39, 2012. [Journal]

1 - 5 of 20 results

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1) Hrabie JA, Keefer LK (submitted in 2005) Polysaccharide-derived Nitric Oxide-releasing Carbon-bound Diazeniumdiolates.
Patents pending: 2006309212 (AU application); 2,628,055 (CA application); 12/092,184 (US application); PCT/US2006/040456 (PC application); 06826062.9 (EP application).

2) Xu X, Keefer LK, Veenstra TD, Ziegler RG (submitted in 2005) Quantitative Measurement Of Fifteen Conjugated And Non-conjugated Estrogen Metabolitets In Blood By Lc/ms.
Patent pending: 12/272,015 (US application).

3) Hrabie JA, Datta A, Friedman C, Keefer LK, Sendijarevic A, Tinkelenberg A (submitted in 2005) Nitric Oxide-releasing Diazeniumdiolated Polymers, Compositions, Medical Devices, And Uses Thereof.
Patent pending: PCT/US08/83375 (PC application).

4) Hrabie JA, Arnold EV, Keefer LK (submitted in 2002) Novel Nitric Oxide-releasing Amidine Diazeniumdiolates, Compositions And Uses Thereof And Method Of Making Same.
Patents issued: 2003261174 (AU, in 2008); 6,949,530 (US, in 2005); 7,348,319 (US, in 2008)
Patents pending: PCT/US03/22292 (PC application); 2487168 (CA application); 03765634.5 (EP application).

5) Bonifant CL, Keefer LK, Saavedra J (submitted in 2000) Superoxide-generating Diazeniumdiolates, Compositions Comprising Same, And Methods For Using Same.
Patents pending: 60/209,067 (US application); PCT/US01/17868 (PC application).

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