All seminars are given at Frederick National Lab on Thursdays at 10:00am in
Building 376, Conference Room 121.
Jan 31Justin DuBois (Stanford University)
"Turning Toxins into Tools for the Study of Ion Channels"
Feb 21Thomas Williamson (Merck, Inc)
"ADEQUATE: NMR Experiments With an Expanding Role in Structure Elucidation"
Apr 4Angela Koehler (The Broad Institute)
“Small-molecule probe discovery for transcriptional regulators”
Apr 25Dan Hammer (University of Pennsylvania)
May 2Chris Lima (MSKCC)
“Structural insights to post-translational modification by Ubiquitin and
May 23Jeff Aube (University of Kansas)
May 30Jon Thorson (University of Kentucky)
"New strategies and tools for natural product diversification and discovery"
Aug 23Julia Kornfield (Cal Tech)
"Crosslinking of Ocular Tissues"
Sep 20Ron Koder (City College NY)
"Protein Design Approaches to Cancer Therapies"
Oct 4Bill Gerwick (UCSD - SIO)
"The Fabulous Natural Products of Marine Cyanobacteria: Structures, Biological Activities,
Nov 8Derek Tan (MSKCC)
"Diversity and Design: New Chemical Probes for Biology and Medicine"
Nov 29Dan Hammer (University of Pennsylvania)
Rescheduled for Spring 2013
Dec 7Sam Gellman (University of Wisconsin)
“Mimicry of Protein Surfaces with Alpha/Beta-Peptide Foldamers”
Cancelled – to be rescheduled at a later date
Dec 13David Spiegel (Yale University)
“Using Small Molecules to Engineer and Explore Human Immunity”
Mar 1John Toscano (Johns Hopkins University)
"Nitroxyl (HNO): Nitric Oxide's Neglected Sibling"
Mar 12*Jim Wells (UCSF)
"Challenging Targets: Reaching for High Hanging Fruit in Drug Discovery"
This seminar is on MONDAY
Apr 5Phil Dawson (TSRI)
"Chemical Ligation: From Post-Translationally Modified Proteins to Nanoparticle
Apr 12Danzhou Yang (University of Arizona)
Apr 19Paul Hanson (University of Kansas)
"Phosphate-Tether Mediated Methods to Bioactive Natural Products and Analogs"
May 3David Lawrence (UNC at Chapel
"Cells Are Poor Cuvette Models: Challenges and Prospects of Molecular Probes
for Intracellular Biochemistry"
May 24Peter Wipf (University of Pittsburgh)
"In Search of the Silver Bullet- Redefining the Academic Drug Discovery Trajectory"
Sep 15Ted Molinski (UCSD)
"Marine Natural Products. Scope, Synthesis-Aided Discovery, and New Approaches"
Oct 6Ben Shen (Scripps Florida)
"Natural Products Drug Discovery: Challenges and Opportunities"
Oct 13Hai-Quan Mao (Johns Hopkins University)
"Controlled Condensation of DNA and Self-Assembled Polymer/DNA Micelles for
Liver-Targeted Gene Delivery"
Nov 3Carlito Lebrilla (UC - Davis)
"Quantitative Measurements of Protein Glycosylation in Diseases and Health"
Nov 10Cheryl Arrowsmith (University
"Structural and Chemical Biology of Readers and Writers of the Histone Code"
Nov 17Matt Bogyo (Stanford University)
"Probing Protease Function Using Small Molecules: Applications from Cancer
Dec 1*Kylie Walters
(University of Minnesota)
"Targeting Proteins for Destruction"
Please note: This seminar will be at 11am instead of 10am.
Jan 20Jiyong Hong (Duke University)
"Natural Product Synthesis at the Interface of Chemistry and Biology"
Feb 3Chris Ireland (University of Utah)
"Antitumor Agents from Marine Organisms"
Feb 24Matt Francis (University of California,
"New Chemical Methods for Site Selective Protein Modification"
Mar 24Dan Kahne (Harvard University)
"How does a cell make more of itself"
Apr 14Brad Moore (University of California,
San Diego/Scripps Institution of Oceanography)
"Genomics-inspired Discovery and Bioengineering of Natural Product Drugs"
May 5Darrell Irvine (Massachusetts
Institute of Technology)
"New materials and new methods for cancer immunotherapy and vaccine delivery"
May 19Bruce Yu (University of Maryland)
"Developing Imaging Agents for 19F MRI"
Aug 19Pieter Dorrestein (University
of California, San Diego)
"Translating Adaptive Metabolism with Imaging Mass Spectrometry"
Sept 9Peter Andreana (Wayne State University)
"Targeting Cellular Immunity with Entirely Carbohydrate-based Constructs"
Sept 16David Corey (University of Texas
Southwest Medical Center)
"Controlling Gene Expression with Synthetic Nucleic Acids"
Oct 7Scott Miller (Yale University)
"Diverse Peptide-Based Catalysis for Diversification of Biologically Interesting
Oct 21Don Engleman (Yale University)
"pH-Dependent Transmembrane Peptide Insertion: Mechanism and Uses in Drug Delivery
and Tumor Imaging"
Nov 4Jean Chmielewski (Purdue University)
Nov 18Henry Kopecek (University of
"Smart Biomaterials and Drug Delivery Systems"