Dr. Martin Schnermann

Dr. Martin Schnermann
Natural Products Chemistry
301-228-4008

Research Summary

Natural Product Covalent Inhibitors

Many small molecule pharmaceutical agents covalently modify their biological targets. Our research will focus on bioactive natural products where the biological target and mechanism of action remains to be rigorously defined. A multidisciplinary, collaborative approach, involving small molecule synthesis, mechanistic and biochemical studies, and biological characterization, will be employed.

New Methods for the Synthesis of Complex Small Molecules

A second, complementary, focus of our efforts will be to develop new synthetic approaches to complex bioactive natural products and their structural analogs. A particular focus will be to develop new methods that enable complex, but readily available, starting materials to be converted to key intermediates in route to target molecules.

Publications

1 - 5 of 7 results

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1) Schnermann MJ, Overman LE.
A Concise Synthesis of (-)-Aplyviolene Facilitated by a Strategic Tertiary Radical Conjugate Addition.
Angew. Chem. Int. Ed. Engl. 2012. [Journal]

2) Schnermann MJ, Untiedt NL, Jiménez-Osés G, Houk KN, Overman LE.
Forming Tertiary Organolithiums and Organocuprates from Nitrile Precursors and their Bimolecular Reactions with Carbon Electrophiles to Form Quaternary Carbon Stereocenters.
Angew. Chem. Int. Ed. Engl. 2012. [Journal]

3) Schnermann MJ, Beaudry CM, Genung NE, Canham SM, Untiedt NL, Karanikolas BD, Sütterlin C, Overman LE.
Divergent synthesis and chemical reactivity of bicyclic lactone fragments of complex rearranged spongian diterpenes.
J. Am. Chem. Soc. 133: 17494-503, 2011. [Journal]

4) Schnermann MJ, Overman LE.
Enantioselective total synthesis of aplyviolene.
J. Am. Chem. Soc. 133: 16425-7, 2011. [Journal]

5) Schnermann MJ, Beaudry CM, Egorova AV, Polishchuk RS, Sütterlin C, Overman LE.
Golgi-modifying properties of macfarlandin E and the synthesis and evaluation of its 2,7-dioxabicyclo[3.2.1]octan-3-one core.
Proc. Natl. Acad. Sci. U.S.A. 107: 6158-63, 2010. [Journal]

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