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Dr. Martin Schnermann


Dr. Martin Schnermann
Organic Synthesis
301-228-4008

Research Summary


Discovery of Near-IR Fluorophores
The discovery and implementation of molecularly targeted imaging modalities has progressed considerably in recent years. Our interest centers on near-IR fluorophores. These compounds are employed extensively in microscopy techniques and in in vivo optical imaging. One such agent, indocyanine green, is FDA approved and is currently involved in over 70 active clinical trials, including over 20 for cancer. Despite a central role in modern biology techniques, the compounds employed in near-IR fluorescence have changed little in recent decades. Using molecular design principles and techniques borrowed from related fields (e.g. medicinal chemistry and modern organic synthesis), we seek to develop new structures and structural classes with improved utility for cancer-related imaging. With synthetic access, these compounds will be applied to microscopy and in vivo imaging techniques and will enable improved readout of a range of biological processes.
Publications
1 - 5 of 7 results

1)  Schnermann MJ, Overman LE.
A Concise Synthesis of (-)-Aplyviolene Facilitated by a Strategic Tertiary Radical Conjugate Addition.
Angew. Chem. Int. Ed. Engl. 2012. [Journal]

2)  Schnermann MJ, Untiedt NL, Jiménez-Osés G, Houk KN, Overman LE.
Forming Tertiary Organolithiums and Organocuprates from Nitrile Precursors and their Bimolecular Reactions with Carbon Electrophiles to Form Quaternary Carbon Stereocenters.
Angew. Chem. Int. Ed. Engl. 2012. [Journal]

3)  Schnermann MJ, Beaudry CM, Genung NE, Canham SM, Untiedt NL, Karanikolas BD, Sütterlin C, Overman LE.
Divergent synthesis and chemical reactivity of bicyclic lactone fragments of complex rearranged spongian diterpenes.
J. Am. Chem. Soc. 133: 17494-503, 2011. [Journal]

4)  Schnermann MJ, Overman LE.
Enantioselective total synthesis of aplyviolene.
J. Am. Chem. Soc. 133: 16425-7, 2011. [Journal]

5)  Schnermann MJ, Beaudry CM, Egorova AV, Polishchuk RS, Sütterlin C, Overman LE.
Golgi-modifying properties of macfarlandin E and the synthesis and evaluation of its 2,7-dioxabicyclo[3.2.1]octan-3-one core.
Proc. Natl. Acad. Sci. U.S.A. 107: 6158-63, 2010. [Journal]

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