Dr. Joel Schneider

Dr. Joel Schneider
Peptide Design and Materials
301-846-5954

Research Summary

The Schneider group designs and characterizes novel materials for use in tissue regenerative therapy, parenteral delivery of therapeutics, delivery of cells, and antibacterial therapy. We are particularly interested in peptide and protein-based hydrogel materials formed by self-assembly mechanisms. Our work spans molecular conception, materials synthesis, nano- and bulk mechanical materials characterization, cell-material interactions, biocompatibility, and assessment of performance efficacy. Our basic research establishes how material composition and structure influences material function, and lays the foundation to ultimately translate materials to the clinic.

Publications

1 - 5 of 71 results

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1) Sinthuvanich C, Veiga AS, Gupta K, Gaspar D, Blumenthal R, Schneider JP.
Anticancer Î²-Hairpin Peptides: Membrane-Induced Folding Triggers Activity.
J. Am. Chem. Soc. 134: 6210-7, 2012. [Journal]

2) Yan C, Mackay ME, Czymmek K, Nagarkar RP, Schneider JP, Pochan DJ.
Injectable solid Peptide hydrogel as a cell carrier: effects of shear flow on hydrogels and cell payload.
Langmuir. 28: 6076-87, 2012. [Journal]

3) Giano MC, Pochan DJ, Schneider JP.
Controlled biodegradation of Self-assembling Î²-hairpin Peptide hydrogels by proteolysis with matrix metalloproteinase-13.
Biomaterials. 32: 6471-7, 2011. [Journal]

4) Altunbas A, Lee SJ, Rajasekaran SA, Schneider JP, Pochan DJ.
Encapsulation of curcumin in self-assembling peptide hydrogels as injectable drug delivery vehicles.
Biomaterials. 32: 5906-14, 2011. [Journal]

5) Nagy KJ, Giano MC, Jin A, Pochan DJ, Schneider JP.
Enhanced mechanical rigidity of hydrogels formed from enantiomeric peptide assemblies.
J. Am. Chem. Soc. 133: 14975-7, 2011. [Journal]

A service of the National Cancer Institute