Dr. John 'Jay' Schneekloth

Dr. John 'Jay' Schneekloth
Synthetic Organic Chemistry and Signal Transduction
301-228-4620

Interested in working in the Schneekloth lab?

Postdoctoral positions are currently available for highly motivated synthetic chemists and chemical biologists. For more information, email Jay at schneeklothjs@mail.nih.gov.

Research Summary

Small Molecule Probes of Ubiquitin-like Signaling

The dynamic modulation of protein posttranslational modifications is a major regulatory mechanism in cellular homeostasis. Greater than 90% of the proteome is regulated by modification with small protein tags such as ubiquitin or ubiquitin-like molecules. The posttranslational ligation or cleavage of these tags affects critical events such as gene transcription, subcellular localization, protein degradation, and many others.

Publications

1 - 5 of 12 results

1 2 3

1) Schneekloth JS, Crews CM.
Natural Product Inhibitors of the Ubiquitin-Proteasome Pathway.
Current drug targets. 2011. [Journal]

2) Schneekloth, Jr. JS, Kim J, Sorensen EJ.
An interrupted Ugi reaction enables the preparation of substituted indoxyls and aminoindoles.
Tetrahedron. 65: 3096-3101, 2009. [Journal]

3) Schneekloth, Jr. JS, Pucheault M, Crews CM.
Construction of Highly Substituted Stereodefined Dienes by Cross-Coupling of alpha-Allenic Acetates.
European Journal of Organic Chemistry. 1: 40-43, 2007. [Journal]

4) Petri AF, Schneekloth JS, Mandal AK, Crews CM.
Synthesis of the C3-C18 fragment of amphidinolides G and H.
Org. Lett. 9: 3001-4, 2007. [Journal]

5) Schneekloth JS, Sanders JL, Hines J, Crews CM.
Neurotrophic peptide aldehydes: solid phase synthesis of fellutamide B and a simplified analog.
Bioorg. Med. Chem. Lett. 16: 3855-8, 2006. [Journal]

A service of the National Cancer Institute

Dr. John 'Jay' Schneekloth

Interested in working in the Schneekloth lab?

Research Summary

Small Molecule Probes of Ubiquitin-like Signaling

Inhibiting Protein-Protein Interactions With Oligomeric Molecules