Dr. Jordan L. Meier

Dr. Jordan L. Meier
Molecular Recognition
301-846-1929

Post-doctoral Postitions

Dr. Meier is currently considering
applications for post-doctoral
fellowship positions.
For inquiries, email Dr.Meier.

Research Summary

Molecular Recognition of Cofactor-Utilizing Enzymes

Enzyme cofactors link cellular metabolism with regulation of gene expression through the activity of chromatin-modifying enzymes. A major goal of the laboratory is the development high-throughput approaches for the discovery of specific probes of cofactor-utilizing enzymes, providing new inhibitor scaffolds and diagnostic agents for profiling cofactor-mediated signaling pathways in cancer cell lines and clinical isolates.

Metabolic Activation of Epigenetic Signaling

Recent studies have shown that many enzymes active in epigenetic mechanisms of genomic regulation are sensitive to the metabolic state of the cell. A second focus of the lab is on understanding the mechanisms by which metabolic perturbations influence protein-protein interactions mediated by chromatin modifying enzymes. In the long term we hope to identify small molecule agents targeting metabolism that reverse epigenetic patterning and disrupt signaling pathways necessary for cancer growth and proliferation.

Highlighted Publications

Meier, J. L., Yu A. S., Korf I., Segal D. J., Dervan P.B.
Guiding the Design of Synthetic DNA-Binding Molecules with Massively Parallel Sequencing.
J. Am. Chem. Soc. 134: 17814-17822, 2012.

Chenoweth D. M., Meier J. L., Dervan P.B.: Pyrrole
Imidazole Polyamides Distinguish Between Double Helical DNA and RNA.
Angew. Chem. Int. Ed. Engl. 2012. (in press)

Publications

1 - 5 of 20 results

1 2 3 4

1) Hargrove AE, Raskatov JA, Meier JL, Montgomery DC, Dervan PB.
Characterization and solubilization of pyrrole-imidazole polyamide aggregates.
J. Med. Chem. 55: 5425-32, 2012. [Journal]

2) Meier JL, Montgomery DC, Dervan PB.
Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns.
Nucleic Acids Res. 40: 2345-56, 2012. [Journal]

3) Meier JL, Yu AS, Korf I, Segal DJ, Dervan PB.
Guiding the Design of Synthetic DNA-Binding Molecules with Massively Parallel Sequencing.
J. Am. Chem. Soc. 134: 17814-22, 2012. [Journal]

4) Raskatov JA, Meier JL, Puckett JW, Yang F, Ramakrishnan P, Dervan PB.
Modulation of NF-kappa-B-dependent gene transcription using programmable DNA minor groove binders.
Proc. Natl. Acad. Sci. U.S.A. 109: 1023-8, 2012. [Journal]

5) Chenoweth DM, Meier JL, Dervan PB.
Pyrrole-Imidazole Polyamides Distinguish Between Double-Helical DNA and RNA.
Angew. Chem. Int. Ed. Engl. 2012. [Journal]

A service of the National Cancer Institute