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Dr. Jim Kelley


Dr. Jim Kelley
Analytical Chemistry
301-846-5955

Research Summary

Dr. Kelley’s research has involved the application of mass spectrometry and high-performance separations to chemical, biochemical, pharmacological and clinical problems in new antitumor and anti-AIDS drug discovery and development. He is also an Instructor for Chemistry 318 (Introduction to Mass Spectrometry in Biomedical Research) for the FAES Graduate School at NIH, an Organizer and Instructor of a short course entitled 'Interpretation of Mass Spectra' for the American Society for Mass Spectrometry, and an Instructor for a tutorial series entitled 'Introduction to Biological Mass Spectrometry' for the Frederick National Lab Mass Spectrometry Interest Group.

PublicationsPatents
1 - 5 of 122 results

1)  Bokesch HR, Cartner LK, Fuller RW, Wilson JA, Henrich CJ, Kelley JA, Gustafson KR, McMahon JB, McKee TC.
Inhibition of ABCG2-mediated drug efflux by naphthopyrones from marine crinoids.
Bioorg. Med. Chem. Lett. 20: 3848-50, 2010. [Journal]

2)  Moon HR, Siddiqui MA, Sun G, Filippov IV, Landsman NA, Lee YC, Adams KM, Barchi JJ, Deschamps JR, Nicklaus MC, Kelley JA, Marquez VE.
Using conformationally locked nucleosides to calibrate the anomeric effect: Implications for glycosyl bond stability.
Tetrahedron. 66: 6707-6717, 2010. [Journal]

3)  Boswell CA, Regino CA, Baidoo KE, Wong KJ, Milenic DE, Kelley JA, Lai CC, Brechbiel MW.
A novel side-bridged hybrid phosphonate/acetate pendant cyclam: synthesis, characterization, and 64Cu small animal PET imaging.
Bioorg. Med. Chem. 17: 548-52, 2009. [Journal]

4)  Russ PL, Gonzalez-Moa MJ, Vu BC, Sigano DM, Kelley JA, Lai CC, Deschamps JR, Hughes SH, Marquez VE.
North- and South-Bicyclo[3.1.0]Hexene Nucleosides: The Effect of Ring Planarity on Anti-HIV Activity.
ChemMedChem. 2009. [Journal]

5)  Duan D, Sigano DM, Kelley JA, Lai CC, Lewin NE, Kedei N, Peach ML, Lee J, Abeyweera TP, Rotenberg SA, Kim H, Kim YH, El Kazzouli S, Chung JU, Young HA, Young MR, Baker A, Colburn NH, Haimovitz-Friedman A, Truman JP, Parrish DA, Deschamps JR, Perry NA, Surawski RJ, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities.
J. Med. Chem. 51: 5198-220, 2008. [Journal]

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