Dr. Larry Keefer

Dr. Larry Keefer
Drug Design
301-846-1467

Research Summary

Link to Diazeniumdiolate Chemistry Database

Nitric oxide (NO) is a potent and multifaceted bioregulatory agent. This project is aimed at finding ways to target NO to specific sites in the body for important research and/or therapeutic applications. Our strategy in pursuing this goal is to begin by characterizing the fundamental chemistry of the NO-releasing diazeniumdiolates (compounds containing the [N(O)NO] functional group). We then attempt to exploit our accumulating knowledge in this area as a platform for solving problems in biomedical research and clinical medicine. We are currently pursuing basic research investigations into the structure, spectra, dissociation to NO and/or HNO, alkylation, arylation

PublicationsPatents

1 - 5 of 231 results

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1) Weidensteiner C, Reichardt W, Shami PJ, Saavedra JE, Keefer LK, Baumer B, Werres A, Jasinski R, Osterberg N, Weyerbrock A.
Effects of the nitric oxide donor JS-K on the blood-tumor barrier and on orthotopic U87 rat gliomas assessed by MRI.
Nitric Oxide. 30C: 17-25, 2013. [Journal]

2) Fuhrman BJ, Pfeiffer RM, Wu AH, Xu X, Keefer LK, Veenstra TD, Ziegler RG.
Green tea intake is associated with urinary estrogen profiles in Japanese-American women.
Nutr J. 12: 25, 2013. [Journal]

3) Holland RJ, Maciag AE, Kumar V, Shi L, Saavedra JE, Prud'homme RK, Chakrapani H, Keefer LK.
Cross-Linking Protein Glutathionylation Mediated by O(2)-Arylated Bis-Diazeniumdiolate 'Double JS-K'.
Chem. Res. Toxicol. 25: 2670-7, 2012. [Journal]

4) Nandurdikar RS, Maciag AE, Cao Z, Keefer LK, Saavedra JE.
Diazeniumdiolated carbamates: a novel class of nitric oxide donors.
Bioorg. Med. Chem. 20: 2025-9, 2012. [Journal]

5) Fuhrman BJ, Schairer C, Gail MH, Boyd-Morin J, Xu X, Sue LY, Buys SS, Isaacs C, Keefer LK, Veenstra TD, Berg CD, Hoover RN, Ziegler RG.
Estrogen metabolism and risk of breast cancer in postmenopausal women.
J. Natl. Cancer Inst. 104: 326-39, 2012. [Journal]

1 - 5 of 20 results

1 2 3 4

1) Wink DA, Andrei D, Keefer LK, Miranda KM, Saavedra J, Salmon DJ (submitted in 2010) Novel Nitroxyl (hno) Releasing Compounds And Use Thereof In Treating Diseases.
Patents pending: 13/582,487 (US application); PCT/US2011/029072 (PC application) Tracking number: E-019-2010/2-EP-02 (EP application).

2) Velazquez Martinez CA, Keefer LK, Knaus EE, Saavedra J, Showalter BM (submitted in 2006) Diazeniumdiolated Non-steroidal, Anti-inflammatory Drugs, Compositions Thereof, And Related Methods.
Patents pending: 2007244903 (AU application); 2,650,383 (CA application); 12/298,322 (US application); PCT/US2007/067295 (PC application); 07782478.7 (EP application).

3) Hrabie JA, Arnold EV, Keefer LK (submitted in 2002) Novel Nitric Oxide-releasing Amidine Diazeniumdiolates, Compositions And Uses Thereof And Method Of Making Same.
Patents issued: 2003261174 (AU, in 2008); 6,949,530 (US, in 2005); 7,348,319 (US, in 2008)
Patents pending: PCT/US03/22292 (PC application); 2487168 (CA application); 03765634.5 (EP application).

4) Fitzhugh AL, Cafferata RL, Keefer LK (submitted in 2000) Highly Cross-linked, Extremely Hydrophobic Nitric Oxide-releaseing Polymers And Methods For Their Manufacture And Use.
Patent issued: 6,703,046 (US, in 2004).
Patents pending: 10/623,239 (US application); 02256854.7 (EP application); 2002-292578 (JP application).

5) Saavedra JE, Akamatsu M, Keefer LK, Roller PP (submitted in 2000) Nitric Oxide-releasing 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium- 1,2-diolates And Composition Comprising Same.
Patent issued: 6,379,660 (US, in 2002).

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