Tell CCR

"Tell CCR" about newly accepted/in press papers prior to online and print publication. Please include a copy of the manuscript in your e-mail to tellccr@mail.nih.gov

Questions may be directed to Donna Kerrigan

CCR Scientific Advances

CCR’s top scientific advances are selected each year by CCR senior staff. These may be promoted in one or more of the following ways:

NCI Cancer Bulletin

CCR connections

The advances selected for 2008 are shown below.

Basic Science

Advances in Signaling

Mechanism of NF-kappB Activation – submission by Jonathan Ashwell, MD

Identification of Dual Roles for Sonic Hedgehog (Shh) Signaling as a Morphogen and Mitogen in Normal Limb Development – submission by Susan Mackem, MD, PhD

Advances in Brain Cancer

Researchers Uncover Errors in Immature Brain Cells in Lab and Animal Studies that May Promote the Growth of Some Brain Tumors – submission by Howard Fine, MD

Advances in HIV/AIDS

Real-Time Visualization of HIV-1 Gag Trafficking in Infected Macrophages – submission by Eric Freed, PhD

Advances in Chromosome Biology

Novel Retrotransposon Surveillance Pathway Important for Host Genome Organization and Maintenance of Genomic Integrity – submission by Shiv Grewal, PhD

Demonstrated Cell Specific Organization of the Chromatin Landscape Is a Critical Determinant of Tissue-selective Receptor Function – submission by Gordon Hager, PhD

Advances in Transcription

Demonstration that Transcription Is Initiated by Transient Transcription Factor Binding – submission by James McNally, PhD

Advances in Immunology

Novel Mechanism for Tumor-induced Subversion of the Immune System – submission by Lalage Wakefield, DPhil

Translation/Clinical Science

Advances in Health Disparities

Researchers Find Biological Factors that May Drive Prostate Tumor Aggressiveness in African-American Men – submission by Stefan Ambs, PhD, MPH

Advances in Imaging

Development of an MR Guided Ultrasound Biopsy/Therapy Platform for Prostate Cancer – submission by Peter Choyke, MD

Advances in Colon Cancer

Unique microRNA Molecular Profiles in Human Colon Cancer Diagnosis and Prognosis – submission by Curt Harris, MD

Advances in Gene Therapy

Virus Shows Promise in Treatment of Blood Disorders in Canines – submission by Dennis Hickstein, MD

Advances in Immunology

Evidence for Lineage Plasticity in Mature Human Neoplastic B Lymphocytes – submission by Elaine Jaffe, MD

Interleukin-7 Therapy Increases T Cell Numbers and Broadens Repertoire Diversity – submission by Crystal Mackall, MD and Ron Gress, MD

Advances in Genetics

Functional Evaluation of Human BRCA2 Variants – submission by Shyam Sharan, PhD

Studying Mutations in Non-Hodgkin Lymphoma Yields Clues for Potential New Therapies – submission by Louis Staudt, MD, PhD

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CCR Scientific Advances

Basic Science

Translation/Clinical Science

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