Figure 1. Phenotypic similarities between hepatocellular carcinomas (HCCs) generated in transgenic mouse models and subclasses A and B of human HCC. The best-fit HCC mouse models can be used to test hypotheses on tumor progression that are generated by analysis of cross-species gene expression patterns or from other experimental data. These models should also be extremely valuable for testing both potential therapeutic targets identified in human studies and preclinical trials of drugs. H, high; L, low; M, medium.