May 2006
Volume 5

Center for Cancer Research: Frontiers in Science

 

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Contents

 
From the Director: Director’s Innovation Awards Presented at the NCI PI Retreat Clinical Research: Radioimmunotherapy of Disseminated Peritoneal Disease Targeting HER2 Clinical Research: Are Radiation Oncologists Serious About Systemic Radiation Therapy, and If Not, Should We Be? Translational Research: Vaccination with Gene-modified Dendritic Cells Protected Transgenic Mice Against Breast Cancer Developmental Biology: Telomere-associated Protein TIN2 Is Essential for Early Embryonic Development Important Information Issue Archive

National Cancer Institute

 

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From the Director

Director’s Innovation Awards Presented at the NCI PI Retreat

Dr. John Niederhuber, Acting Director, NCI, presented the 2006 Director’s Innovation Awards to recipients at an award ceremony held during the NCI Intramural Scientific Retreat on January 11. I worked closely with Drs. von Eschenbach and Niederhuber to develop this award program as a means to stimulate highly innovative proposals on cancer-related research problems from our junior staff. Based on the overwhelming response and the high quality of proposals received, it is clear that the program was a success, and is therefore likely to be repeated in the future. Of the 120 applicants in this round from CCR, 8 awards at the PI level (up to $50,000) and 20 awards at the Career Development level (up to $10,000) were presented. Please join with me in congratulating the recipients on their outstanding achievement.

Robert Wiltrout, PhD
Director

PI Award Recipients:

Mirit Aladjem, PhD, Laboratory of Molecular Pharmacology, CCR

Single Molecule Studies of Replication Dynamics in Normal and Cancer Cells

Daniel Fowler, MD, PhD, Experimental Transplantation and Immunology Branch, CCR

Allograft T-cell Engineering for Therapy of Metastatic Renal Cell Carcinoma

Jeffrey Gildersleeve, PhD, Laboratory of Medicinal Chemistry, CCR

Application of Carbohydrate Microarrays to Cancer and HIV Vaccine Development

Mikhail Kashlev, PhD, Gene Regulation and Chromosome Biology Laboratory, CCR

Nanobiochemistry: Monitoring of Basic Biochemical Processes

Javed Khan, MD, Pediatric Oncology Branch, CCR

Sensitive and Specific Detection of miRNA Using Luminex Beads and Locked Nucleic Acid

Stan Lipkowitz, MD, PhD, Laboratory of Cellular and Molecular Biology, CCR

Identification of Molecular Targets in ER-Negative, PR-Negative, and HER2/Neu-Negative Breast Cancer

Andre Nussenzweig, PhD, Experimental Immunology Branch, CCR

Mechanisms of Cancer-associated Chromosomal Translocations

Ying Zhang, PhD, Laboratory of Cellular and Molecular Biology, CCR

Smad3 Adenovirus as a Novel Cancer Therapeutic Treatment for Hepatocellular Carcinoma

Career Development Award Recipients:

Praveen Arany, PhD, Postdoctoral Fellow, Laboratory of Cell Regulation and Carcinogenesis, CCR

Wound Matrix as a Paradigm for Modeling the Cancer Microenvironment

Katherine Calvo, MD, PhD, Clinical Fellow, Laboratory of Pathology, CCR

Real-time In Vivo Proteomic Profiling of Human Tumors Perfused with Targeted Inhibitors

Joan L. Cmarik, PhD, Staff Scientist, Laboratory of Cancer Prevention, CCR

Does Viral Infection Play a Role in Bronchioloalveolar Adenocarcinoma of the Lung?

Albert Gold, PhD, Staff Scientist, Laboratory of Genomic Diversity, CCR

Defining Breast Cancer Risk Modifier Genes

Mark Hoenerhoff, PhD, and Hark Kim, MD, PhD, Postdoctoral Fellows, Laboratory of Cell Regulation and Carcinogenesis, CCR

Creation of Relevant Genetically Engineered Mouse Models for Gastric Cancer

Cary Hsu, MD, and Richard Morgan, PhD, Surgery Branch, CCR

Evaluation of Cybr and IL-15 in Leukemogenesis: Applications for Adoptive Cell Transfer

Su Young Kim, MD, PhD, Postdoctoral Fellow, Pediatric Oncology Branch, CCR

CXCR4 Determines Dormancy and the Metastatic Phenotype in Osteosarcoma Cells

Maria Kireeva, PhD, Postdoctoral Fellow, Gene Regulation and Chromosome Biology Laboratory, CCR

Wound Matrix as a Paradigm for Modeling the Cancer Microenvironment

Juhong Liu, PhD, Staff Scientist, Laboratory of Pathology, CCR

Survey of p38/JTV Targets Using ChIP-on-chip and Mammalian Two-hybrid Screening

Philip Lorenzi, PhD, Postdoctoral Fellow, Laboratory of Molecular Pharmacology, CCR

A New Bioinformatic Approach for Identification of Synergistic Drug Combinations

Diane Palmieri, PhD, Staff Scientist, Laboratory of Molecular Pharmacology, CCR

A Novel Use for Lithium as a Treatment for Breast Cancer Brain Metastases

Alison Rattray, PhD, Staff Scientist, Gene Regulation and Chromosome Biology Laboratory CCR

Isolation of DNA Palindromic Amplicons from Human Tumor Cells

Brad Scroggins, PhD, Postdoctoral Fellow, Urologic Oncology Branch, CCR

Using Yeast Genetics to Probe the In Vivo Consequences of Hsp90 Acetylation

Nadya I. Tarasova, PhD, Staff Scientist, Structural Biophysics Laboratory, CCR

Self-assembling Nanoparticles Targeting G-protein–Coupled Receptors and ABC Transporters

Yien Che Tsai, PhD, Postdoctoral Fellow, Laboratory of Protein Dynamics and Signaling, CCR

Mitochondrial Dynamics and Its Relationship to Ubiquitination and to Apoptosis in Cancer

Edward C. Wu, PhD, Postdoctoral Fellow, Retroviral Replication Laboratory, HIV DRP, CCR

Recombinant Human Telomerase Reverse Transcriptase

Matthew R. Young, PhD, Staff Scientist, Laboratory of Cancer Prevention, CCR

Targeting Translation Initiation: A Drug Discovery Proposal

Yanlin Yu, PhD, Postdoctoral Fellow, Laboratory of Cell Regulation and Carcinogenesis, CCR

Novel Substrates of the PTEN Protein Phosphatase in Metastasis Pathways

David Zaharoff, PhD, Postdoctoral Fellow, Laboratory of Tumor Immunology and Biology, CCR

Development of Multi-layer Chitosan Nanoparticles for the Delivery of Cancer Vaccines

M. Raza Zaidi, PhD, Postdoctoral Fellow, Laboratory of Cell Regulation and Carcinogenesis, CCR

Response of the Melanocyte Genome to Ultraviolet Radiation: A New Perspective

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