Figure 1. Regulation of skin pigmentation. A) Histology of human skin; black melanin pigment is seen just above the dermal-epidermal border. B) Schematic showing types of cells present in the epidermis and dermis. C) Schematic of tyrosinase processing and degradation within melanocytes. After maturation in the Golgi, tyrosinase is trafficked either to melanosomes for melanin synthesis or to the degradation machinery. ER, endoplasmic reticulum.