Figure 1. A model for the cellular response to glucose-phosphate stress where SgrR and SgrS function to modulate the transporter for glucose. A) The PtsG transporter brings glucose into the cell, phosphorylating it in the process. B) Accumulated glucose-phosphate is proposed to interact with the regulatory protein SgrR to stimulate transcription of the regulatory RNA SgrS, which binds to the RNA chaperone Hfq. C) SgrS pairs with the mRNA encoding PtsG, leading to degradation of the small RNA and the ptsG mRNA. This downregulates further transport of glucose into the cell, limiting the accumulation of toxic sugar-phosphates.