Figure 1. Germline stem cells (GSCs) “drift away” from the niche in Gef26 mutant testes because of impaired adherens junctions. The Wild-type (A), Gef264 (B), and Gef266 (C) testes of adult flies were immunostained with anti–E-cadherin (green), anti-Vasa (red), and DAPI (blue). In (A), all GSCs are anchored to the hub (star) through E-cadherin–positive adherens junctions. In (B), all Vasa-positive germ cells drifted away from the hub (star). In (C), only one GSC is still attached to the hub (star) through E-cadherin–positive adherens junctions (arrow).