Figure 1. Modulation of Sipa1 levels significantly influences the metastatic capacity of a highly metastatic mouse mammary tumor cell line. Wild-type cells (center), cells overexpressing (right; FVB Sipa1), or cells silenced (left; siRNA) for the Sipa1 gene were implanted into the flanks of mice and allowed to develop into tumors. The metastatic capacity was then determined by counting lung surface nodules. Representative images of the lungs from each group are shown above the scatterplots. The black bars represent the median value for each experimental group.