Read short, plain-language summaries of significant research papers that CCR scientists
and their collaborators have contributed to the oncology research community.
Vol. 7, No. 1, 2013 - Training the Next Generation of Cancer Researchers.
At CCR, predoctoral students along with postdoctoral and clinical fellows work at the intersection of basic science
and clinical medicine. And with ready access to patients, clinical trials, tumor samples, and advanced technology,
CCR's aspiring investigators pursue translational research in a collaborative setting that puts a high priority on professional development.
View the media coverage that results from seminal discoveries made by CCR's translational
Cancer has eluded us for centuries, but the researchers at NCI's Center for Cancer
Research (CCR) remain undaunted. They are bringing real hope, real progress. Our
camera will bring you into their labs and clinics to see this progress for yourself.
Resources for the Media and Public
Resources for Our Staff
Repair Mechanism of UV-damaged DNA in Xeroderma Pigmentosum
Xeroderma pigmentosum (XP) is a rare, inherited disorder characterized by extreme skin sensitivity to ultraviolet (UV) rays from sunlight.
HIV envelope glycoprotein imaged at high resolution
The outer surface of the human immunodeficiency virus (HIV) is surrounded by an envelope studded with spike-shaped glycoproteins called Env that help the deadly virus identify, bind, and infect cells.
Combination Therapy Improves Survival in Prostate Cancer Model
James Hodge, Ph.D., Head of the Recombinant Vaccine Group in CCR’s Laboratory of Tumor Immunology and Biology, and his colleagues have devised a therapy against CRPC that combines enzalutamide, an androgen-receptor antagonist, with a vaccine against Twist, a transcription factor implicated in cell mobility and metastasis.
Virtual Entity Yields Real-Time Results
Genomic technologies have revolutionized cancer research, but not without analytical challenges. No single researcher can manage the vast datasets generated by next-generation sequencing and other modern genomic tools. Harnessing those tools in the pursuit of translational advances increasingly compels team science and multidisciplinary collaboration. Toward that end, NCI's Center of Excellence in Integrative Cancer Biology and Genomics (CEICBG) was created in 2008 to unite experts in cancer biology with colleagues in bioinformatics.
Training the Next Generation of Cancer Researchers
Staffed by nearly 250 principal investigators (PIs) and linked to the world's largest, publicly funded research hospital, CCR offers a wealth of opportunities for graduate and postgraduate training. At CCR, predoctoral students along with postdoctoral and clinical fellows work at the intersection of basic science and clinical medicine. And with ready access to patients, clinical trials, tumor samples, and advanced technology, CCR's aspiring investigators pursue translational research in a collaborative setting that puts a high priority on professional development.
It Starts with a Choice: Cancer Cells and Their Decisions to Replicate
A Senior Investigator in CCR's Laboratory of Molecular Pharmacology (LMP), Mirit Aladjem, Ph.D., has a long-held fascination with the choices cells make when DNA replication goes awry. She realized that the use of alternative signaling pathways lies at the heart of cancer's survival mechanisms—cells that choose to replicate unstable DNA and then divide can seed tumors, while those that choose to self-destruct by apoptosis can impede tumor growth.
A service of the National Cancer Institute