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Chemical Biology Laboratory

Selected News Items

Molecular Discovery Series Seminar - Spring 2013 Line-up
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Please click on link to see the Spring 2013 schedule. All seminars are given at Frederick National Lab on Thursdays at 10:00am in Building 376, Conference Room 121
Dr. Jordan Meier joins the CBL
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The CBL welcomes Dr. Jordan Meier as a new tenure-track investigator. Jordan's research focuses on molecular recognition and epigenetic signaling. Please visit Dr. Meier's website for more information.
Burke Group Receives IATAP Award
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Dr. Xue Zhi Zhao, a staff scientist in the Burke Group, and Dr. Terrence Burke have been awarded an Intramural AIDS Targeted Antiviral Program (IATAP) Award for their proposal entitled, "Design and Synthesis of New Agents Targeting Raltegravir-resistant Mutants of HIV-1 Integrase." The IATAP program is a competitive mechanism within the Office of the Director, NIH, which provides funds for the development of targeted anti-virals for HIV, structural and functional studies of HIV proteins, or closely related areas in the molecular and cell biology of HIV. The award supports the work Dr. Zhao, author of the proposal, which is a collaborative undertaking with investigators from the laboratories of Dr. Yves Pommier and Dr. Stephen Hughes (both of the NCI) and Dr. Peter Cherepanov (London Research Institute)
Dr. Larry Keefer - 50 Year ACS Member
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Dr. Larry Keefer was honored as a 50-Year ACS Member at the Chemical Society of Washington November dinner meeting on November 8, 2012. Learn more about Dr. Keefer's research at
Burke Group develops the world's highest affinity Polo-like kinase polo-box domain binding antagonists
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New Targeted Therapies Available for Licensing: Inhibitors of Polo-like Kinase 1. See CCR Connections for the full article
Dr. Ryan Holland - 2012 FARE Winner
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Dr. Ryan Holland, a CRTA Fellow in the Keefer group, was named a winner at the 2012 NIH Intramural Research Festival. The 26th annual research festival was held October 9-12 on the NIH campus in Bethesda MD. Dr. Holland's poster, entitled 'Crosslinking Glutathionylation Mediated by O2-Arylated (Bis)diazeniumdiolate "Double JS-K" ' was deemed outstanding based on the scientific merit, originality, experimental design and the overall quality and presentation. The FARE 2012 Award is a competitive award within the NIH and includes a $1000 award for travel to attend and present original work at a scientific meeting within the United States
Dr. Jeff Gildersleeve awarded tenure
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Dr. Jeff Gildersleeve was unanimously awarded tenure and promoted to Senior Investigator in the CBL. Visit Jeff's website for more on his research in chemical glycobiology.
Cem Sonmez - PEM 6 Award Winner
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Congratulations to doctoral candidate, Cem Sonmez, a 2012 award winner at the Sixth Peptide Engineering Meeting (PEM6). The meeting was held in early October at Emory University in Atlanta, GA
Dr. Martin Schnermann joins the CBL
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The CBL welcomes Dr. Martin Schnermann as a new tenure-track investigator. Martin's research focuses on natural product synthetic organic chemistry. Please visit Dr. Schernmann's website for more information
MDP Seminar Series - 2012 Fall Line-up
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All seminars are given at Frederick National Lab on Thursdays at 10:00am in Building 376, Conference Room 121
CBL Investigator "Covers" ChemBioChem
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Exposed! ChemBioChem cover story by CBL Investigator Terry Burke reveals all in September 2012 issue
2012 Spring Research Festival Winner Sudipa Chowdury
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Sudipa Chowdhury, a CRTA Fellow in the Gildersleeve group, was named a winner in the Post-Baccaulaureate (Student) category at poster presentations of the 2012 Ft. Detrick Spring Research Festival. Ms. Chowdury's poster was entitled "Serum Anti-Glycan Antibodies as Biomarkers for Ovarian Cancer"
Book Release: Petite and Sweet: Glyco-Nanotechnology as a Bridge to New Medicines
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Edited by CBL Senior Scientist, Joe Barchi, this book describes current progress in the glyco-nanotechnology field. It will provide the readers with knowledge of the current status of glyco-nanotechnology research and kindle additional interests in this field. There are tremendous opportunities in biomedical applications of glyconanomaterials and we have just begun to uncover them. ISBN: 978-0-8412-2688-3
CBL Fellow wins 2011 Federal Technology Transfer Award
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The CBL congratulates Dr. Wenjian Qian, a research fellow in the labs of Dr. Terrence Burke, on winning a 2011 Federal Technology Transfer Award
2011 Spring Research Festival Winners from CBL
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Three Fellows from the CBL were selected as Poster Presentation Winners of the 2011 NCI-Frederick/Ft. Detrick Spring Research Festival. In the Post Baccalaureate/Student category Gildersleeve Group member Sean Llewellyn won the award for his presentation, "High-Throughput Glycan Microarray Profiling of Humoral Responses to the Ad5hr-SIV Vaccine" (VGT2). Dr. Christopher Campbell, also of the Gildersleeve group, won a spot in the Post Doctoral Fellows category for his poster, "High-throughput glycan microarray for identifying biomarkers of cancer vaccine efficacy" (VGT1). Barchi group Post Doctoral Fellow, Dr. Kritie Adams, was also named a winner in this same category for her presentation, "Structural studies of antiproliferative factor glycopeptide analogs: Synergistic peptide and sugar conformational effects" (SBC16)
CBL article and artwork selected for ChemBioChem cover
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The cover picture shows how siRNAs modified with North bicyclo[3.1.0]hexane-2’-deoxy-pseudosugars are able to activate the RNA interference machinery. The paper confirms that the North conformation is critical for RNAi activity. For further details, see Effect of North Bicyclo[3.1.0]hexane 2’-Deoxypseudosugars on RNA Interference: A Novel Class of siRNA Modification by Montserrat Terrazas, Sandra M. Ocampo, Jose Carlos Perales, Victor E. Marquez and Ramon Eritja in ChemBioChem 2011, 12, 1056-1065
$10K CPA awarded to Burke Group CRTA Fellow
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Dr. Medhanit Bahta (a CRTA Fellow in the CBL Burke group) has received a Collaborative Project Award (CPA) sponsored by the National Interagency Confederation for Biological Research (NICBR). Her proposal is centered on the application of substrate activity screening for the development of the Vaccinia virus VH1 phosphatase. This work will be conducted in collaboration with Dr. Bryan Zhao of the Laboratory of Molecular Immunology at the US Army Medical Research Institute of Infectious Diseases (USAMRIID).
The CPA program is designed to foster scientific interaction by supporting new projects which specifically benefit from the expertise available in NICBR labs. This award provides $10,000 to each investigator
2 FARE Winners selected from the CBL
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Dr. Medhanit Bahta of the Burke group and Kristy Adams of the Barchi group have each been selected as winners of the Fellows Award for Research Excellence (FARE) 2012 competition. Each of their presentations was deemed outstanding based on the scientific merit, originality, experimental design and the overall quality and presentation.
The FARE 2012 Award is $1000 awarded to attend and present original work at a scientific meeting within the United States. FARE 2012 is sponsored by the NIH Scientific Directors, the Office of Intramural Training & Education, the Office of Research on Women's Health, as well as the Fellows Committee
Dr. Victor Marquez inducted into the ACS Division of Medicinal Chemistry Hall of Fame
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Dr. Victor Marquez has been inducted into the ACS Division of Medicinal Chemistry Hall of Fame. Please go to for more detail
CBL boasts 3 winners at the 2010 Spring Research Festival
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In the Structural Biology and Chemistry category, Dr. Medhanit Bahta of the Burke group won for her poster entitled "Development of Yersinia pestis protein tyrosine phosphatase(YopH) inhibitors using a substrate activity screening approach".
Awards in the Vaccines and Gene Therapy category were given to Dr. Raymond P. Brinas of the Barchi group for his poster entitled "Development of a Novel Cancer Vaccine Based on Multivalent Presentation of Tumor-Associated Carbohydrate Antigens on a Gold Nanoparticle Scaffold" and to Dr. Christoper Campbell of the Gildersleeve group for his poster entitled "Glycan microarray for monitoring the immune response to a cancer vaccine"
CBL's Dr. Olaf Ludek wins international award
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Dr. Olaf Ludek won first prize for his poster entitled "Synthesis of conformationally locked carbocyclic 1,3-dizapinone nucleosides as inhibitors of cytidine deaminase." at the 2008 XVIII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids held in Kyoto, Japan
Dr. Campbell wins Best Poster Award
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The Cambridge Isotope Labs, Glycoscience & Understanding Cancer, Best Poster Award (sponsored by Cambridge Isotope Labs) was awarded to Dr. Christopher Campbell for his poster entitled "High-Throughput Glycoarray for Monitoring Immune Responses to a Cancer Vaccine" at the 2010 NIH/FDA Glycoscience Day. Dr. Campbell is a PRAT Fellow in Dr. Gildersleeve's group
Dr. Marquez to address Pharmaceutical Society of Korea 2009 Fall International Convention
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Dr. Victor Marquez, former Lab Chief and Scientist Emeritus from the LMC will give a plenary lecture entitled "Chemical Libraries of Diacylglycerol Lactones Targeting C1 Domains" at the 2009 Fall international Convention of the Pharmaceutical Society of Korea. The convention will be held from Oct 15-16, 2009 at the Hotel Seoul Kyoyuk MunHwa HoeKwan
Dr. Gildersleeve to present at the Fall 2009 ACS National Meeting & Exposition - Young Investigator's Symposium
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Dr. Jeff Gildersleeve of the LMC has been chosen as a speaker for the upcoming Young Investigator's Symposium at the 238th ACS National Meeting and Expositions - August 16-20, 2009 in Washington, DC. Please see the ACS website for symposium schedule and details
Dr. Marquez to give R.U. Lemieux Lecture on Biotechnology
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Dr. Victor Marquez will give the R. U. Lemieux Lecture on Biotechnology at the University of Alberta, Canada, on Thursday, May 7, 2009 at 4:00 PM (Rm 2-115 Education North). His talk is entitled: "What are the consequences of freezing the anomeric effect in nucleosides?"
2008 Maryland Chemist of the Year Award
Dr. Victor Marquez has been selected as the 2008 Maryland Chemist of the Year by the Maryland Section of the American Chemical Society. The award will be presented at the local ACS chapter dinner meeting on December 10, 2008 at the Burkshire Marriott in Towson, MD, where as the award recipient, Dr. Marquez will also give a presentation
2008 Mid-Atlantic Region Frontiers at the Chemistry & Biology Interface Selects Two from the LMC
Dr. Jeffrey Gildersleeve has been selected to top off the morning session of the 2008 Frontiers at the Chemistry & Biology Interface Symposium with an oral presentation entitled "Application of Carbohydrate Microarray Technology to Cancer Research". In addition, Dr. Victor Marquez will close out the symposium with his oral presentation entitled "D-(+)-iso-Methanocarbathymidine, a High Affinity Substrate for HSV-tk". The 2008 Frontiers at the Chemistry & Biology Interface Symposium will be held on Saturday, April 12, 2008 from 8:30am - 4:30pm at the at the University of Maryland, College Park
Midwest Carbohydrate & Glycobiology Symposium Crowns Two Winners from the LMC
Dr. Andreas Sundgren was presented with an award for "Outstanding Poster Presentation" by Dr. George O'Doherty (West Virginia University) at the Midwest Carbohydrate & Glycobiology Symposium. In addition, Dr. Joseph Barchi received the award for "Best Dressed and Most Elegant" amongst the symposium attenders. See Gallery for pictures
LMC Boasts Two 2008 FARE Winners
Dr. Oyindasola Oyelaran and Dr. Andreas Sundgren of the Laboratory of Medicinal Chemistry are among the winners of this year's NIH Fellows Award for Research Excellence (FARE). This award, begun in 1995, recognizes outstanding scientific research performed by intramural postdoctoral fellows. Winners of FARE awards will each receive a $1000 stipend to attend a scientific meeting at which they will present their research
Dr. Marquez receives the Leopoldo Garcia-Colin-Scherer medal
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Dr. Victor Marquez was awarded the Leopoldo Garcia-Colin-Scherer Medal at the Third Mexican Meeting on Mathematical and Experimental Physics in Mexico City, Mexico (Sept 10-14, 2007). It is the highest recognition of the Physics Department at UAM-Iztapalapa for excellence in scientific research. The award consists of a gold medal and a certificate mentioning the winner's major contributions. This distinction recognizes outstanding international scientists for their contributions to the development of science. For more information click on Leopoldo Garcia-Colin-Scherer Medal on the website
2007 NIH Director's Award
Dr. Marc C. Nicklaus, a senior-scientist in the LMC, was presented with the 2007 NIH Director's Award by for extraordinary scientific leadership of the "Molecular Libraries and Imaging Roadmap to enable research on new pathways to discovery in health and disease". This award was presented by NIH Director Dr. Elias A. Zerhouni on June 13, 2007
LMC's Dr. Christopher Lai wins international award
Dr. Christopher Lai, a mass spectroscopist in the LMC, was presented with an award for "excellent presentation of particularly significant innovative analytical research" at the 30th International Symposium on Capillary Chromatography in Dalian, China (June 5-7, 2007)
LMC NAR cover article selected by Dr. Wiltrout
The journal cover article of Dr. Victor E. Marquez entitled "Caught in the Act: Visualization of an Intermediate in the DNA Base-flipping Pathway Induced by HHAI Methyltransferase" published with co-authors John R. Horton, Gary Ratner, Nilesh K. Banavali, Niu Huang, Yongseok Choi, Martin A. Maier, Alexander D. MacKerell, Jr., and Xiaodong Cheng in Nucleic Acids Research was selected by Dr. Wiltrout for display in the CCR-OD conference
room. Nucleic Acids Res., Jul 2004; 32: 3877-3886. See gallery
LMC PNAS cover article graces the CCR-OD Conference Room
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The journal cover article of Dr. Terrence Burke entitled "Discovery of a Small-Molecule HIV-1 Integrase inhibitor-Binding Site" published with co-authors Laith Q. Al-Mawsawi, Valery Fikkert, Raveendra Dayam, Myriam Witvrouw, Christoph H. Borchers, and Nouri Neamati in Proceedings of the National Academy of Sciences USA was selected by Dr. Wiltrout for display in the CCR-OD conference room. PNAS 2006 103: 10080-10085. See gallery
LMC Chief in the spotlight
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Dr. Victor E. Marquez, Chief, Laboratory of Medicinal Chemistry was the subject of a recent spotlight at NCI-Frederick
2007 NCI Director's Innovation Award
Dr. Oyindasola Oyelaran, a postdoctoral fellow in Jeff Gildersleeve's laboratory was a career development recipient of the NCI Director's Innovation Award for 2007 for her proposal entitled "Comparative microarray profiling of human sera to identify glycan cancer biomarkers"

This page was last updated on 12/6/2012.