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Laboratory of Human Carcinogenesis

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In addition to the information presented below, the LHC has an alternative website that can provide you with more detail about their work.

Overview

The Laboratory of Human Carcinogenesis has a multifaceted research program integrating basic, translational, clinical, and population research with a major focus on common and lethal human cancers that include tumors of the breast, colon, esophagus, liver, lung, pancreas and prostate. Our main objectives are to conduct investigations to assess: (1) mechanisms of carcinogenesis including the cellular functions of cancer driving genes; (2) experimental approaches in biological systems for the extrapolation of carcinogenesis data and mechanisms from in vitro models and experimental animals to humans; (3) molecular integrative epidemiology of human cancer risk; and (4) cancer biomarkers of diagnosis, prognosis, and therapeutic outcome.

The laboratory consists of three sections, the Liver Carcinogenesis Section (LCS), the Molecular Genetics and Carcinogenesis Section (MGCS), and the Molecular Epidemiology Section (MES); and the Pancreatic Cancer Unit (PCU). Scientifically, the emphasis is on the role of inherited or acquired host factors as important determinants of an individual's cancer susceptibility and outcomes. Our investigations of host factors involve interspecies studies among laboratory animals and humans, and are multidisciplinary, to include molecular and cellular biology, pathology, epidemiology, and clinical investigation. The MGCS headed by Dr. Curt Harris devotes their major efforts to more fundamental and mechanistic studies. The LCS headed by Dr. Xin Wang focuses mainly on dissecting tumor heterogeneity of liver cancer to improve outcome among diverse populations and identifying cancer drivers through integrated genomics. The MES headed by Dr. Stefan Ambs mainly conducts integrative molecular epidemiology studies of prostate cancer and breast cancer with a special emphasis on health disparity and utilizes epidemiological and translational research strategies to identify risk factors and pathways that influence tumor development and progression. The PCU headed by Dr. Perwez Hussain conducts integrative molecular epidemiology studies of pancreatic cancer utilizes epidemiological and translational research strategies to identify risk factors and pathways that influence tumor development and progression. The overall goal of LHC is to acquire knowledge that will improve cancer prevention, early detection, stratification and effective treatment.

This page was last updated on 9/4/2013.