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Laboratory of Genome Integrity

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Genomic instability is a key event in cancer, aging and various heritable diseases. Highly conserved pathways have evolved to detect the presence of an unstable genome and affect its repair. In a newly established department we are exploring the nature and causes of genomic instability, the mechanisms of DNA repair and the consequences of failure in DNA repair with respect to cancer development. The program will emphasize mechanistic understanding of the pathways that maintain genomic integrity, the intersection of these pathways with normal cellular physiology and cancer, as well as the application of these insights to clinical problems. In addition, we envision that the combination of hypothesis driven approaches and unbiased screening strategies will aid in the development of new therapeutic strategies and targets that selectively kill cancer cells without harming normal cells.

This page was last updated on 2/5/2013.