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Laboratory of Metabolism

Overview

The Laboratory of Metabolism (LM), founded in 1996, consists of five principal investigators. Members of the LM are international leaders in drug and carcinogen metabolism, mechanisms of chemical carcinogenesis, nuclear receptors, mammalian developmental biology, chromosomal proteins and chromatin biology, studies on B-ZIP transcription factors, and the control of mitosis by protein kinases, and cell cycle regulation. We have distinct but overlapping research interests focusing on areas that include 1) drug and carcinogen metabolism, 2) chemical carcinogenesis and chemoprevention, 3) mechanisms of carcinogenesis, 4) signal transduction and cell cycle control, 5) developmental biology, 6) epigenetic gene regulation and chromatin biology. The LM has a comprehensive research program that aims to translate basic biological findings into experimental systems used for the development of drugs and the determining the risk assessment of chemicals affecting carcinogenesis and developmentally related abnormalities leading to tumors. Our research has significant impact beyond just our laboratory. We generated unique reagents, such as recombinant cytochrome P450s; transcription factors and chromatin proteins; genetically altered mice for chromosomal protein-encoding genes; multiple nuclear receptor and transcription factor gene knock-out mice; conditional knock-out mice; tissue-specific Cre mice; P450 and nuclear receptor humanized mice; antibodies to P450s, transcription factors and chromatin components; recombinant dominant negative proteins to B-ZIP transcription factors; POLO kinase inhibitors and assay systems for cancer diagnosis that have been distributed to numerous laboratories in the U.S. and throughout the world.

This page was last updated on 7/1/2014.