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Laboratory of Metabolism


The Laboratory of Metabolism (LM), founded in 1996, consists of five principle investigators. Members of the LM are international leaders in drug and carcinogen metabolism, nuclear receptors, mammalian developmental biology, chromosomal proteins and chromatin biology, in studies on B-ZIP transcription factors, and in the control of mitosis by protein kinases. We have distinct but overlapping research interest focusing on areas that include 1) drug and carcinogen metabolism, 2) chemical carcinogenesis and chemoprevention, 3) mechanisms of carcinogenesis, 4) signal transduction and cell cycle control, 5) developmental biology, 6) gene regulation and chromatin biology. The LM has a comprehensive research program that aims to translate basic biological findings into experimental systems used for the development of drugs and the risk assessment of chemicals affecting carcinogenesis and developmentally related abnormalities leading to tumors. Our research has significant impact beyond just our laboratory. We generated unique reagents, such as recombinant cytochrome P450s, transcription factors and chromatin proteins, multiple nuclear receptor and transcription factor gene knock-out conditional knock-out and humanized mice, antibodies to P450s and chromatin components, and dominant negative proteins to B-ZIP transcription factors, and distributed them to numerous laboratories in the US and throughout the world.

This page was last updated on 4/12/2011.