Our Science – CBL Website
Chemical Biology Laboratory
Gallery Pictures |
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| PNAS cover article graces the CCR-OD Conference Room |
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| The lowest energy-binding conformation of an inhibitor bound to the dimeric interface of HIV-1 integrase core domain. The yellow region represents a unique allosteric binding site identified by affinity labeling and mass spectrometry and validated through mutagenesis. This site can provide a potential platform for the rational design of inhibitors selective for disruption of integrase multimerization. See the article by Dr. Terry Burke et al. in this issue [PNAS 2006 103: 10080-10085]. |
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| NAR cover article |
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| HHAI methyltransferase (blue ribbon) bound to oligonucleotide (strands with bonds colored yellow and green) containing a pseudorotationally constrained sugar analogue at the target position (orange bonds with cyan atoms). The south-constrained pseudosugar is rotated about its flanking phosphodiester bonds, 90 degrees from its initial position in B-form DNA, but short of a completely flipped position with 180 degrees in the middle of the flipping pathway via the major groove side. This structure provides clues to DNA-protein interactions in a potential transition state. For further details see the paper by Dr. Victor Marquez et al. in this issue [Nucleic Acids Res. (2004) 32, 3877-3886]. |
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| Dr. Oyinda Oyelaran Receives the 2007 NCI Director's Innovation Award |
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| Congratulations to Dr. Oyinda Oyelaran on receiving the 2007 NCI Director's Innovation Award. Dr. Oyelaran accepts the award from NCI Director, Dr. John E. Niederhuber. |
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| Dr. Joseph Barchi receives Midwest Carbohydrate & Glycobiology Symposium Award |
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| Dr. Barchi receiving his "2007 Best-Dressed & Most Elegant" award from Dr. Jeff Gildersleeve (National Cancer Institute). |
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| Dr. Andreas Sundgren receives Midwest Carbohydrate & Glycobiology Symposium Award |
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| Dr. Andreas Sundgren of the National Cancer Institute being presented the "2007 Outstanding Poster Presentation" award by Dr. George O'Doherty (West Virginia University). |
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| Dr. Ludek wins XVIII RT Poster Award |
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| Standing back row right is Dr. Olaf Ludek, poster award winner from the 2008 XVII International Round Table on Nucleosides, Nucleotides and Nucleic Acids in Kyoto, Japan |
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| 2011 FARE Winners |
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| Dr. Medhanit Bahta of the CBL, 2nd from the right in the 2nd row, along with the other 2011 NIH FARE winners. Congratulations Dr. Bahta. |
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| MD Seminar Series - 2013 Spring Line-up |
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This page was last updated on 12/6/2012.
