Suresh K. Arya, Ph.D.
Lentiviral vectors for gene transfer in gene therapy and functional genomics
Designing safer lentiviral vectors
Regulation of lentiviral vectors in vivo
Genetic immunization in AIDS
Andrew Blauvelt, M.D.
Cellular and molecular interactions between HIV and dendritic cells
Pathogenesis of Kaposi's sarcoma
Robert Blumenthal, Ph.D.
Elucidation of physical, structural, dynamic, and kinetic factors that determine relative resistance/sensitivity of HIV and SIV to entry inhibitors and antibody-mediated neutralization
The role of CD4, co-receptors, membrane lipids, and signaling in the triggering of conformational changes in HIV/SIV Env
Determination of functional domains of HIV/SIV Env by photosensitized labeling
John M. Coffin, Ph.D.
Population dynamics, genetics, and evolution of HIV in vivo
Dimiter S. Dimitrov, Ph.D., Sc.D.
HIV entry: mechanisms, inhibitors and vaccines
Development of human monoclonal antibodies against viruses of biodefense importance
Eric A. Engels, Ph.D.
AIDS-related cancers, including Kaposi's sarcoma and non-Hodgkin's lymphoma
Polyomaviruses (SV40, BK, and JC) and cancer
Genoveffa Franchini, M.D.
Live vector avipox- and vaccinia-based HIV-1 vaccines
Preventative immunization
Therapeutic immunization
Mechanisms of HTLV-1 oncogenesis
Eric O. Freed, Ph.D.
HIV and retroviral assembly and release
Interactions between viral and cellular proteins
Trafficking of retroviral proteins
Envelope glycoprotein incorporation and function
David J. Garfinkel, Ph.D.
Modulators of Ty1 retrotransposition in S. cerevisiae, emphazing genes involved genome stability and RNA metabolism
The molecular basis of Ty1 cosuppression, which is a copy number dependent process used to limit the number of transposable elements in the genome
James J. Goedert, M.D.
Kaposi's sarcoma (KS) among people infected with the KS-associated herpesvirus, especially the roles of human genetics and cofactors (smoking, environmental exposures, skin hygiene, underlying immune perturbations) in the development of this malignancy
the natural history of hepatitis C virus (HCV) infection, especially determinants of hepatocellular carcinoma and non-Hodgkin's lymphoma
known and putative AIDS-associated malignancies
Michie Hisada, M.D., Sc.D.
Role of viral markers and risk of HTLV-I infection and pahogenesis
Genetic susceptibility to HTLV-I infection and disease pathogenesis
International comparison of HTLV-I natural history
Oncogenic coinfections
Epidemiology of Helicobacter pylori
Wei-Shau Hu, Ph.D.
Mechanisms of reverse transcription and recombination
RNA packaging and virus assembly
Interactions between distinct viruses
Stephen H. Hughes, Ph.D.
Retroviral replication
Structure and function of HIV reverse transcriptase
Retroviral vectors
Vineet N. KewalRamani, Ph.D.
Virus-host interactions
Role of DC-SIGN in HIV transmission
Development of animal models for HIV infection/transmission
Stuart F. J. Le Grice, Ph.D.
Protein footprinting by mass spectrometry
Bioconjugate evaluation of reverse transcription complexes
RNase H inhibitors
Unnatural amino acids as probes of protein structure and function
Vinay K. Pathak, Ph.D.
Retroviral replication
RT structure, fidelity, and template switching
Development of gene therapy vectors
Viral drug resistance
George N. Pavlakis, M.D., Ph.D.
HIV molecular biology and pathogenesis
Regulation of gene expression
DNA vaccine development and optimization for prophylaxis and therapy
Alan Rein, Ph.D.
Molecular mechanisms of retroviral replication
Interactions of retroviral proteins with nucleic acids
Viral pathogenicity
Marjorie Robert-Guroff, Ph.D.
AIDS vaccine development; adenovirus recombinant approaches; humoral, cellular and mucosal immunity correlated with protection; pre-clinical and clinical studies
Immunologic approaches to diagnosis, prevention and treatment of retroviral-induced diseases
Mechanisms of host resistance to retroviral infection
Mark Schiffman, M.D., M.P.H.
HPV and related neoplasia
John T. Schiller, Ph.D.
Papillomaviruses
Vaccines
Cervical cancer
Virus assembly
Infectious process
Virion structure/function
Steven L. Zeichner, M.D., Ph.D.
KSHV gene expression program
HIV replication and the expression of selected HIV gene products on the host cell
Clinical trials in HIV-infected children