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Department of Health and Human Services     The NCI Center for Cancer Research is part of the National Institutes of Health (NIH), U.S. Department of Health and Human Services.

  National Institutes of Health
Position Title: Postdoctoral Fellow
Contact Name: Kevin Gardner
Contact Phone: 301-496-1055
Contact Fax: 301-435-7558
Contact E-mail:
Branch/Laboratory/Program: Genetics Branch
Investigator's Home Page:
Number of Positions Available: 2

Research Area Key Words:

Epigenetic, transcriptional regulation
CV Required? Yes
Number References Required: 3
Publications List Required? Yes
Position Description: Two positions are available in the Transcription Regulation Section of the Genetics Branch of the Center (Center) for Cancer Research to study mechanisms of epigenetic and transcriptional regulation in cancer. Specific work in the section is focused on defining transcriptional and epigenetic mechanism that link molecular imbalance with cancers of the breast and colon. Current projects include: 1) Defining the role and mechanism of the C-terminal binding protein (CtBP) in linking metabolic imbalance to increased risk and severity of breast and colon cancers.(delete -.) 2) Defining the mechanistic role of epigenetic regulators including p300, BRCA1 and CtBP in the control of early transcriptional elongation in breast cancer, colon cancer, and leukemaia/lymphoma. 3) Defining key roles played by CtBP-dependent gene regulatory networks and epigenetic pathways in obesity-associated cancer and cancer health disparities.
Experience Required: Candidates should have a Ph.D. or equivalent with no more than five years post-doctoral experience in chromatin biology with a strong background (delete and) in molecular biology including familiarity and experience with chromatin immuno-precipitation (ChIP) and broad based gene expression profiling. Experience in animal models, histology or handling human samples would be an asset. Applicants with a background in bioinformatics are encouraged to apply. Qualified candidates should have an established track record of scientific achievement including publication in peer-review journals and good communications skills. Successful candidates will join a highly integrated multi-disciplinary team that applies genomic profiling and basic molecular approaches to (understand) causative mechanisms in cancer biology with direct application to strategies for cancer treatment and prevention.
Additional Information: Interested individual should send a 1-2 page statement of research interests and career goals, a CV and bibliography, and 3 letters of reference.
Location: NCI-Bethesda
Department of Health and Human ServicesNIH is part of the Department of Health and Human Services