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Department of Health and Human Services     The NCI Center for Cancer Research is part of the National Institutes of Health (NIH), U.S. Department of Health and Human Services.

  National Institutes of Health
Position Title: Postdoctoral Fellow
Contact Name: Rosandra Kaplan, MD
Contact Phone: 301-496-1735
Contact Fax: 301-451-7052
Contact E-mail:
Branch/Laboratory/Program: Pediatric Oncology Branch
Investigator's Home Page:
Number of Positions Available: 1

Research Area Key Words:

Metastasis, Pre-Metastatic niche
CV Required? Yes
Number References Required: 3
Publications List Required? Yes
Position Description: I am looking for a hard working and energetic postdoctoral fellow interested in the area of cancer biology. The position is in the laboratory of Dr. Rosandra Kaplan within the Pediatric Oncology Branch of the National Cancer Institute (NCI), part of the National Institutes of Health (NIH) in Bethesda, Maryland.

This is an exciting opportunity to join a basic and translational research program focused on the role of the host microenvironment in establishing metastasis. Our research has established the concept of the pre-metastatic niche (Nature 2005), which suggests bone marrow-derived cells promote cancer metastasis by establishing a conducive microenvironment for tumor cells to adhere and grow in distant sites. Our research focuses on the basic understanding of normal and abnormal stem cells, stem cell niche biology, tumor-host interaction, immune response to cancer and vasculogenesis. The goal of the laboratory is to develop novel approaches to classify and treat patients at risk for and with metastatic disease. We isolate bone marrow-derived cells in the circulation and tissues of mice and humans and are working to characterize the gene expression changes within these cells and tissues in order to better understand the necessary, early changes critical for metastatic progression.

Projects involve: identification and characterization of bone marrow-derived cells associated with pre-metastatic niche formation, translational studies involving patient blood and tissue samples, the use of cell lines and mouse models with molecular and cellular biology technologies to develop novel treatment strategies.
Experience Required: I would like candidates who have a Ph.D. or M.D. PhD degree and are seeking a postdoctoral experience. I am seeking applicants with a strong background in molecular cancer biology, in particular having some experience in computational biology including microarray analysis. Candidates with a background in cancer stem cell or developmental biology are encouraged to apply. Candidates who are hard working, self-motivated and career-oriented are sought to join a new and exciting research team. The candidate does not need their own funding prior to arrival.
Additional Information:
Location: NCI-Bethesda
Department of Health and Human ServicesNIH is part of the Department of Health and Human Services