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Department of Health and Human Services     The NCI Center for Cancer Research is part of the National Institutes of Health (NIH), U.S. Department of Health and Human Services.

  National Institutes of Health
Position Title: Postdoctoral Fellow
Contact Name: Brian A. Lewis
Contact Phone: 301-435-8323
Contact Fax: 301-496-9956
Contact E-mail: lewisbri@mail.nih.gov
Branch/Laboratory/Program: Metabolism Branch
Investigator's Home Page: http://ccr.cancer.gov/staff/staff.asp?profileid=15165
Number of Positions Available: 1

Research Area Key Words:

 Transcriptional regulation, RNA polymerase II
CV Required? Yes
Number References Required: 3
Publications List Required? Yes
Position Description: The Lewis laboratory of the Metabolism Branch, Center for Cancer Research, National Cancer Institute seeks applications for postdoctoral fellow positions. The research interests of the lab revolve around the transcriptional regulation of eukaryotic genes by RNA polymerase II. The first focus is on understanding the mechanisms of transcriptional regulation of O-GlcNAcylated RNA polymerase II C-terminal domain. The second project deals with understanding the transcription biology of the NF-kB REL transcriptional activators. This includes using crude and reconstituted in vitro transcription systems to identify and purify the factors required for the regulation of O-GlcNAcylated RNA pol II-dependent transcription. Similar approaches will be use to determine the coactivator requirements of the relA, c-rel, and relB transcription factors and their role in B-cell lymphomas. Other complimentary techniques such as microarrays, shRNA knockdown, ChIP and ChIP/seq, and bioinformatics will be implemented to assess the in vivo and genome-wide regulation of REL/NF-kB family members in B-cell lymphomas and the molecular physiology of O-GlcNAc-dependent transcriptional regulation.
Experience Required: The successful candidate will have a Ph.D. degree with a strong publication record in molecular biology and/or biochemistry and less than three years of postdoctoral experience. US citizenship is not required but proficiency in English is essential.
Additional Information:
Location: NCI-Bethesda
   
Department of Health and Human ServicesNIH is part of the Department of Health and Human Services