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Department of Health and Human Services     The NCI Center for Cancer Research is part of the National Institutes of Health (NIH), U.S. Department of Health and Human Services.

  National Institutes of Health
Position Title: Postdoctoral Fellow
Contact Name: Karlyne Reilly
Contact Phone: 301 846 7518
Contact Fax: 301 846 7017
Contact E-mail:
Branch/Laboratory/Program: Mouse Cancer Genetics Program
Investigator's Home Page:
Number of Positions Available: 1

Research Area Key Words:

Astrocytoma, NF1, Mouse Models
CV Required? Yes
Number References Required: 3
Publications List Required? Yes
Position Description: The Genetic Modifiers of Tumorigenesis Section of the Mouse Cancer Genetics Program at NCI-Frederick is recruiting a post-doctoral fellow to study modifiers of cancer susceptibility. We have identified at least 6 regions of the genome that affect whether mice are more or less susceptible to astrocytoma or malignant peripheral nerve sheath tumors. Projects are available to test gene candidates and understand the molecular mechanisms underlying these effects. The laboratory is located on the Frederick campus of NCI with many state-of-the-art facilities for genomic analysis, pathology, small animal imaging, and proteomic analysis, among others (

Projects include 1) characterizing candidate modifier genes for glial tumors and neurofibromatosis type I at the genetic, cellular, and molecular level; 2) studying the role of genome architecture and imprinted genes in susceptibility to cancer; 3) studying sex-specific differences in susceptibility to cancer.
Experience Required: Candidates are expected to have completed, or be completing, a Ph.D. or M.D./Ph.D. in biomedical research with a strong publication record and expertise in molecular and cell biological techniques. Candidates should have no more than one year of post-doctoral experience. Expertise in protein-protein interactions, signal transduction, and/or chromatin structure is preferred, but individuals with experience in imprinted genes, cancer biology, neurofibromatosis, mouse modeling, or tumors of the nervous system are also strongly encouraged to apply. The ideal candidate should demonstrate passion for science, the ability to work independently and efficiently, and the ability to think critically and creatively about scientific problems. Strong verbal and written communication skills are required.
Additional Information: Interested applicants should send their curriculum vitae, a brief description of their research interests and career goals, and contact information for three references to Dr. Karlyne Reilly by email to
Location: NCI-Frederick
Department of Health and Human ServicesNIH is part of the Department of Health and Human Services