Full Name: (to appear on your certificate)

1. HIF-1α expression:
   A  is increased by reactive nitrogen species
   B  is unaltered by reactive oxygen species
   C  is increased by prolylhydroxylase
   D  all of the above
   E  none of the above
   
   
2. Reactive oxygen species:
   A  cause lipid peroxidation
   B  cause DNA strand breaks
   C  cause protein nitration
   D  all of the above
   E  none of the above
   
   
3. H₂O₂ is a product of which enzyme(s)?
   A  Glucose oxidase
   B  Polyamine oxidase
   C  Xanthine Oxidase
   D  all of the above
   E  none of the above
   
   
4. Inflammation markers include:
   A  peroxidase
   B  superoxide dismutase
   C  nitric oxide synthase
   D  all of the above
   E  none of the above
   
   
5. Thrombospondin:
   A  increases angiogenesis
   B  inhibits p38 MAP kinase
   C  decreases apoptosis
   D  all of the above
   E  none of the above
   
   
6. Tempol:
   A  increases radiation sensitivity
   B  is a radioprotector
   C  increases superoxide concentrations
   D  all of the above
   E  none of the above
   
   
7. Infections associated with cancer include:
   A  Hepatitis B and cervical cancer
   B  Epstein-Barr virus and cervical cancer
   C  Helicobacter pylori and gastric cancer
   D  all of the above
   E  none of the above
   
   
8. Cannabinoids:
   A  decrease myocardial infarct size
   B  cause hypertension
   C  reduce progression of atherosclerosis
   D  all of the above
   E  none of the above
   
   
9. NSAIDs:
   A  increase phase 1 activation enzymes (e.g., CYP1A)
   B  decrease glutathione
   C  increase carcinogenesis
   D  all of the above
   E  none of the above
   
   
10. Soluble guanylate cyclase:
    A  is a monomer
    B  has selenium
    C  is nitrosylated by NO
    D  all of the above
    E  none of the above
    
    
11. Which technique uses radioisotopes (e.g., ¹⁸F)?
    A  MRI
    B  CT
    C  PET
    D  all of the above
    E  none of the above
    
    
12. NADPH oxidases:
    A  generate reactive oxygen species
    B  have a heme
    C  cross the plasma membrane several times
    D  all of the above
    E  none of the above
    
    
    
    Please review your answers and make any changes that needed. If you are done, please submit your answers and your exam will be computer graded. If you answer 10 of the questions correct, you will be forwarded to the course evaluation.