Recent advances in the biochemistry of redox-active species and radicals are beginning to be translated into improvements in prevention and treatment of cancer. Traditionally, reactive species such as superoxide, hydrogen peroxide and nitric oxide (NO) are associated with toxicity; however, NO is useful in the treatment of angina and cardiovascular disease. Also, NO is involved in cancer tumor angiogenesis and apoptosis of cancer cells. This course is an overview presenting how redox-active species and radicals are generated; their effects on the cellular and physiological level, how they alter carcinogenesis, angiogenesis and proliferation in animal models of cancer, and how NO alters patient imaging profiles and response to cancer therapy. It consists of two 1-hour lectures with ample time for discussion and analysis. The participation of postdoctoral and clinical fellows interested in redox biology is encouraged.
Location and Time
A variety of instructors from NCI/NIH teach this course.
David Wink, Ph.D.
Terry Moody, Ph.D.
Jonathan Wiest, Ph.D.
For Additional Information
Contact Dr. Terry Moody at firstname.lastname@example.org or by phone at 301-451-9451.
Related Training Opportunities
This course is part of an ongoing training curriculum for NCI clinical and postdoctoral fellows. Each fall CCR offers the “Translational Research in Clinical Oncology (TRACO)” course, hosted by Dr. Terry Moody. Another course, "Demystifying Medicine" is held each spring. This course provides 2 hours of lecture each week (January – May) and is hosted by Dr. Irvin M. Arias. To learn about additional training opportunities at NIH, visit https://www.training.nih.gov/
A service of the National Cancer Institute