The NCI CCR announces a course for NIH Fellows: Redox Biology

Overview

Recent advances in the biochemistry of redox active species and radicals are beginning to be translated into improvements in prevention and treatment of cancer. Traditionally, these reactive species like superoxide, hydrogen peroxide and nitric oxide are associated with toxicity, however, nitric oxide is useful in the treatment of angina and cardiovascular disease. Also, nitric oxide is involved in cancer tumor angiogenesis and apoptosis of cancer cells. The course will overview how redox active species and radicals are generated, their effects on the cellular and physiological level, how they alter carcinogenesis, angiogenesis and proliferation in animal models of cancer, and how nitric oxide alters patient imaging profiles and response to cancer therapy.

The Redox Biology course will be held on Tuesday afternoons from 4-6 p.m. on October 16 to November 27, 2007 at the Bethesda Campus, Bldg. 50, Rooms 1227/1233. Redox Biology is designed to provide an overview of general principles of nitric oxide biochemistry, cell biology, signal transduction, physiology, carcinogenesis, chemoprevention, angiogenesis, therapy, immunology and epidemiology. The participation of NIH Postdoctoral and Clinical Fellows interested in redox biology is encouraged.

Links and Related Training Opportunities
This course is part of a developing curriculum for training NCI clinical and postdoctoral fellows. Translational Research in Clinical Oncology (TRACO), which runs from Sept.-Dec. concerns new methods for diagnosing and treating cancer. TRACO complements other topics in human diseases and therapies covered in "Demystifying Medicine for PhDs" which runs from January to May.: http://list.nih.gov/cgi-bin/show_list_archives. In February, a course in “Statistical Analysis of Research Data” (SARD) is offered for NCI Clinical and Postdoctoral fellows. For additional training opportunities at NIH view http://www.training.nih.gov.

Location and Time
Redox Biology will consist of one hour lectures held on Tuesdays, 4-6 p.m., Bldg. 50, Rms. 1227/1233. Each session will have a 50-min lecture with ample time for discussion and analysis. A handout for each lecture will be distributed on site.

Registration
Register Now!
Deadline for Registration is October 9, 2007. The first 100 registrants will be accommodated. For more information contact Dr. Terry Moody, by e-mail (moodyt@mail.nih.gov) by FAX (301-480-4323) or by phone (301-451-9451). There is no registration fee.

Certificate
There is no fee for this course. Participants, who register for the course, may receive a certificate of completion after completion of the final examination.

Faculty
Steering Commitee:	Faculty:
David Wink, PhD	S. Ambs PhD	T. Moody PhD
Terry Moody, PhD	K. Gardner PhD	R. Pluta MD
Jonathan Wiest, PhD	M. Gladwin MD	D. Roberts PhD
	P. Hussain PhD	H. Young, PhD
	M. Krishna PhD	D. Wink PhD
	J. Mitchell PhD	G. Yeh PhD

Schedule and Speakers
Date	Lecture	Speakers: 4 p.m., 5 p.m.
Oct. 16	Introduction, Redox Chemistry	T. Moody, D. Wink
Oct. 23	Redox Biology, Physiology	D. Wink, M. Gladwin
Oct. 30	Signal Transduction, CNS	T. Moody, R. Pluta
Nov. 6	Epidemiology, Inflammation	S. Ambs, P. Hussain
Nov. 13	Angiogenesis, Carcinogenesis	D. Roberts, G. Yeh
Nov. 20	Immunology, Genomics	H. Young, K. Gardner
Nov. 27	Imaging, Cancer Therapy	M. Krishna, J. Mitchell

PowerPoint Presentations
Date added	Title	Size
10/16	Redox Biology: Introduction	~7MB
10/16	Redox Biology: Chemistry	<1MB
10/24	Redox Biology: Biochemistry	<1MB
10/24	Emerging Biology	~14MB
10/30	Signal Transduction	~5MB
10/30	CNS Part A Part B	~10MB, ~28MB
11/6	Oxidative Stress	<1MB
11/6	Inflammation	7.6MB
11/13	Carcinogenesis	4MB
11/13	Angiogenesis Part A Part B Part C
11/19	Genomics	~9MB
11/20	Cancer Treatment	~19MB
11/27	Imaging	~7MB
11/27	ImmunologyPart A Part B