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Redox Biology

Overview
Recent advances in the biochemistry of redox active species and radicals are beginning to be translated into improvements in prevention and treatment of cancer. Traditionally, reactive species such as superoxide, hydrogen peroxide and nitric oxide are associated with toxicity; however, nitric oxide is useful in the treatment of angina and cardiovascular disease. Also, nitric oxide is involved in cancer tumor angiogenesis and apoptosis of cancer cells. This course will be an overview presenting how redox active species and radicals are generated, their effects on the cellular and physiological level, how they alter carcinogenesis, angiogenesis and proliferation in animal models of cancer, and how nitric oxide alters patient imaging profiles and response to cancer therapy.

The Redox Biology course will be held on Tuesday afternoons from 4:00-6:00 PM starting September 28 through November 8, 2010 on the Bethesda campus, Bldg. 50, Rooms 1227/1233. Redox Biology is designed to provide an overview of general principles of nitric oxide biochemistry, cell biology, signal transduction, physiology, carcinogenesis, chemoprevention, angiogenesis, therapy, immunology and epidemiology. The participation of NIH Postdoctoral and Clinical Fellows interested in redox biology is encouraged.

Related Training Opportunities
This course is part of an ongoing curriculum for training NCI clinical and postdoctoral fellows. Translational Research in Clinical Oncology (TRACO), which runs from September-December concerns new methods for diagnosing and treating cancer. TRACO complements other topics in human diseases and therapies covered in "Demystifying Medicine for PhDs" which runs from January-May.  For additional training opportunities at NIH visit http://www.training.nih.gov.

Location and Time
Redox Biology will consist of two 1-hour sessions held on Tuesdays, 4:00-6:00 PM, Bldg. 50, Rms. 1227/1233.  Each session will have a 50-minute lecture with ample time for discussion and analysis. A handout for each lecture will be distributed on site.

Registration
Registration for the Redox Biology course is free of charge. Please register online at http://ccr.ncifcrf.gov/careers/courses/rb/registration/form.asp. A Redox Biology Workshop will be held on November 16, 2010. The workshop will be from 9:30 AM - 5:00 PM. in Bldg. 10, Lipsett Amphitheater. For more information contact Dr. Terry Moody by e-mail at moodyt@mail.nih.gov or by phone at 301.451.9451.

Final Exam and Certificate
Participants will receive a certificate after passing the final examination.
The 2010 Final Exam is now available at http://ccr.cancer.gov/careers/courses/rb/exam/default.asp