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Cancer, Genetics, and Signaling Fellows Program

Center for Cancer Research, NCI-Frederick

The Cancer, Genetics, and Signaling (CGS) Group at the National Cancer Institute at Frederick (NCI-Frederick) offers a competitive postdoctoral training and mentoring program focusing on molecular and genetic aspects of cancer. The CGS Fellows Program is designed to attract and train exceptional postdoctoral fellows interested in independent research career tracks.

The CGS group is highly interactive and multidisciplinary and includes 20 principal investigators from 4 departments: Cancer and Developmental Biology, Cell and Developmental Signaling, Protein Dynamics and Signaling, and Mouse Cancer Genetics. Fields of research range from identification and characterization of novel oncogenes and tumor suppressors to the control of cell proliferation and survival, epigenetics, transcriptional and translational regulation, signal transduction, RNA biology, mouse models of cancer and development, normal and cancer stem cells, and translational studies in preclinical models. For more detailed descriptions of the research interests of participating faculty members, please follow the links on this page.

CGS Fellow positions are internally funded. However, trainees are encouraged to apply for outside funding such as postdoctoral training and transition grants (e.g., K99, K22). Fellows will participate in a structured mentoring program focused on scientific and career development and transition to independent positions. Supplemental funds for travel to scientific meetings will also be provided. The CGS Fellows Program features weekly laboratory meetings, a Distinguished Scientist seminar series and a rich research environment. Investigators in the Program have a strong history of placing postdoctoral trainees in tenure-track assistant professor positions or equivalent positions of leadership.

The NCI Center for Cancer Research (CCR) campus in Frederick, Maryland offers state-of-the-art mouse genetics, proteomics, and high-throughput sequencing core facilities, as well as drug discovery, structural biology, and other advanced technologies.

Applicants should be within one year of receiving their Ph.D./M.D. degree and not more than two years past receiving their degree. Applications are reviewed and candidates selected for the program in the autumn of each year. The application deadline is September 5, 2013, and selected candidates will be notified by September 10. A group of approximately 8 finalists will be invited to visit NCI-Frederick for interviews on October 8 through October 9/10, 2013. The interview process will consist of presenting a short talk on your research, interviewing with potential mentors, meeting with the current CGS Fellows, and other activities. Invitees will travel to NCI-Frederick from Bethesda on October 8 and depart at the end of the day on October 9 or early on October 10. All travel and lodging will be pre-arranged by the NGSRC and CGS programs and is coordinated with your trip to NIH.

To apply to the CGS Fellows Program, please email Cheri Rhoderick ( by Thursday, Sept. 5, 2013 at NOON. Your email message should include a list of 3 CGS principal investigators ( with whom you wish to interview. Further questions should be directed to Dr. Peter Johnson ( or Dr. Susan Mackem (, co-Chairs of the CGSFP Steering Committee, or Cheri Rhoderick (

The National Cancer Institute, National Institutes of Health is an equal opportunity/ affirmative action employer. Qualified women, minorities, and individuals with disabilities are encouraged to apply.


Participating Investigators and Research Interests:

Cancer and Developmental Biology Laboratory

Mark Lewandoski - Genetics of vertebrate development with an emphasis on FGF and BMP signaling
Susan Mackem - Regulatory networks in vertebrate patterning and morphogenesis
Alan Perantoni - Signaling mechanisms in renal progenitor specification and patterning
Terry Yamaguchi - Wnt signaling pathways and stem cells in the vertebrate embryo

Laboratory of Cell and Developmental Signaling

Jairaj Acharya - In vivo study of sphingolipid/phospholipid signaling
Ira Daar - Cell adhesion and movement in morphogenesis
Deborah Morrison - Molecular mechanisms of Ras pathway regulation in normal and oncogenic signaling
Esta Sterneck - Molecular mechanisms of mammary and breast tumor cell development and metastatic progression
Christopher Westlake - Membrane trafficking pathways in primary cilium signaling and cancer

Laboratory of Protein Dynamics and Signaling

Allan Weissman - The ubiquitin system in normal cellular processes and disease
Jadranka Loncarek - Synchronization between cell- and centrosome- cycles and molecular mechanisms of centriole reduplication

Mouse Cancer Genetics Program

Karlyne Reilly - Modifiers, mechanisms, and mouse models of neurofibromatosis and brain tumors
Shyam Sharan - Genomic instability and breast cancer susceptibility
Brad St. Croix - Tumor angiogenesis
Lino Tessarollo - Role of neurotrophins in development and disease
Terry Van Dyke - Cancer pathways and mechanisms
Pengnian Charles Lin - Tumor microenvironment with an emphasis on inflammation and tumor angiogenesis
Peter Johnson - Transcriptional control of oncogene-induced senescence and tumorigenesis; spatial regulation of Ras signaling
Jonathan Keller - Molecular regulation of normal stem cell development
Kathrin Muegge - Epigenetic regulation of chromatin function and carcinogenesis

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