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Our Science – Weissman Website

Allan M. Weissman, M.D.

Selected Publications

1)  Metzger MB, Liang YH, Das R, Mariano J, Li S, Li J, Kostova Z, Byrd RA, Ji X, Weissman AM.
A structurally unique E2-binding domain activates ubiquitination by the ERAD E2, Ubc7p, through multiple mechanisms.
Mol. Cell. 50: 516-27, 2013.
2)  Das R, Liang Y, Mariano J, Li J, Huang T, King A, Tarasov SG, Weissman AM, Ji X, Byrd RA.
Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine.
EMBO J. 32: 2504-16, 2013.
3)  Tsai YC, Leichner GS, Pearce MM, Wilson GL, Wojcikiewicz RJ, Roitelman J, Weissman AM.
Differential Regulation of HMG-CoA Reductase and Insig-1 by Enzymes of the Ubiquitin-Proteasome System.
Mol. Biol. Cell. 23: 4484-94, 2012.
4)  Leboucher GP, Tsai YC, Yang M, Shaw KC, Zhou M, Veenstra TD, Glickman MH, Weissman AM.
Stress-Induced Phosphorylation and Proteasomal Degradation of Mitofusin 2 Facilitates Mitochondrial Fragmentation and Apoptosis.
Mol Cell. 47: 547-57, 2012.
5)  Weissman AM, Shabek N, Ciechanover A.
The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation.
Nat. Rev. Mol. Cell Biol. 12: 605-20, 2011.
6)  Shao J, Choe V, Cheng H, Tsai YC, Weissman AM, Luo S, Rao H.
Ubiquitin ligase gp78 targets unglycosylated prion protein PrP for ubiquitylation and degradation.
PLoS ONE. 9: e92290, 2014.
7)  Byrd RA, Weissman AM.
Compact Parkin only: insights into the structure of an autoinhibited ubiquitin ligase.
EMBO J. 32: 2087-9, 2013.
8)  Metzger MB, Pruneda JN, Klevit RE, Weissman AM.
RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination.
Biochim. Biophys. Acta. 1843: 47-60, 2013.
9)  Weissman AM.
Ubiquitin and drug discovery: challenges and opportunities.
Cell Biochem. Biophys. 67: 1-2, 2013.
10)  Tsai YC, Weissman AM.
A Ubiquitin-Binding Rhomboid Protease Aimed at ERADication.
Dev. Cell. 23: 454-6, 2012.
Click Here to View Expanded Bibliography.

This page was last updated on 5/20/2014.