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Our Science – Burke Website

Terrence R. Burke Jr., Ph.D.

Selected Publications

1)  Liu F, Park JE, Qian WJ, Lim D, Gräber M, Berg T, Yaffe MB, Lee KS, Burke TR.
Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel.
Nat. Chem. Biol. 7: 595-601, 2011.
[Journal]
2)  Bahta M, Liu F, Kim SE, Stephen AG, Fisher RJ, Burke TR.
Oxime-based linker libraries as a general approach for the rapid generation and screening of multidentate inhibitors.
Nat Protoc. 7: 686-702, 2012.
[Journal]
3)  Liu F, Park J, Qian W, Lim D, Scharow A, Berg T, Yaffe MB, Lee KS, Burke TR.
Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification.
ACS Chem Biol. 7: 805-10, 2012.
[Journal]
4)  Qian W, Liu F, Burke TR.
Investigation of unanticipated alkylation at the N(TT) position of a histidyl residue under Mitsunobu conditions and synthesis of orthogonally protected histidine analogues.
J. Org. Chem. 76: 8885-90, 2011.
[Journal]
5)  Nelson CG, Burke TR.
Samarium iodide-mediated Reformatsky reactions for the stereoselective preparation of beta-hydroxy-gamma-amino acids: synthesis of isostatine and dolaisoleucine.
J. Org. Chem. 77: 733-8, 2012.
[Journal]
6)  Zhao XZ, Smith SJ, Métifiot M, Johnson BC, Marchand C, Pommier Y, Hughes SH, Burke TR.
Bicyclic 1-Hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-Containing HIV-1 Integrase Inhibitors Having High Antiviral Potency Against Cells Harboring Raltegravir-Resistant Integrase Mutants.
J. Med. Chem. 2014.
[Journal]
7)  Qian WJ, Lai CC, Kelley JA, Burke TR.
Design and synthesis of N-FMoc-Thr[PO(OH)(OPOM)] for the preparation of peptides prodrugs containing phosphothreonine in fully protected form.
Chem. Biodiver. 2013.
In Press. [Journal]
8)  Métifiot M, Maddali K, Johnson BC, Hare S, Smith SJ, Zhao XZ, Marchand C, Burke TR, Hughes SH, Cherepanov P, Pommier Y.
Activities, crystal structures and molecular dynamics of dihydro-1H-isoindole derivatives, inhibitors of HIV-1 integrase.
ACS Chem. Biol. 8: 209-217, 2013.
[Journal]
9)  Hogan M, Bahta M, Cherry S, Lountos GT, Tropea JE, Zhao BM, Burke TR, Waugh DS, Ulrich RG.
Biomolecular Interactions of Small-molecule Inhibitors Affecting the YopH Protein Tyrosine Phosphatase.
Chem Biol Drug Des. 81: 323-333, 2013.
[Journal]
10)  Qian WJ, Burke TR.
Design and synthesis of a reagent for solid-phase incorporation of the phosphothreonine mimetic (2S,3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) into peptides in a bio-reversible phosphonyl-bis-pivaloyloxymethyl (POM) prodrug form.
Amino Acids. 45: 1143-8, 2013.
[Journal]
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This page was last updated on 2/3/2014.