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Cheryl Ann Winkler, Ph.D.

Selected Publications

1)  Thomson R, Genovese G, Canon C, Kovacsics D, Higgins MK, Carrington M, Winkler CA, Kopp J, Rotimi C, Adeyemo A, Doumatey A, Ayodo G, Alper SL, Pollak MR, Friedman DJ, Raper J.
Evolution of the primate trypanolytic factor APOL1.
Proc. Natl. Acad. Sci. U.S.A. [Epub ahead of print], 2014.
[Journal]
2)  Liang Y, Tang W, Huang T, Gao Y, Tan A, Yang X, Zhang H, Hu Y, Qin X, Li S, Zhang S, Mo L, Liang Z, Shi D, Huang Z, Guan Y, Zhou J, Winkler C, O'Brien SJ, Xu J, Mo Z, Peng T.
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
PLoS ONE. 9: e97923, 2014.
[Journal]
3)  Galanter JM, Gignoux CR, Torgerson DG, Roth LA, Eng C, Oh SS, Nguyen EA, Drake KA, Huntsman S, Hu D, Sen S, Davis A, Farber HJ, Avila PC, Brigino-Buenaventura E, Lenoir MA, Meade K, Serebrisky D, Borrell LN, Rodríguez-Cintrón W, Estrada AM, Mendoza KS, Winkler CA, Klitz W, Romieu I, London SJ, Gilliland F, Martinez F, Bustamante C, Williams LK, Kumar R, Rodríguez-Santana JR, Burchard EG.
Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: The Genes-environments & Admixture in Latino Americans study.
J. Allergy Clin. Immunol. [Epub ahead of print], 2014.
[Journal]
4)  An P, Goedert JJ, Donfield S, Buchbinder S, Kirk GD, Detels R, Winkler CA.
Regulatory variation in HIV-1 dependency factor ZNRD1 associates with host resistance to HIV-1 acquisition.
J. Infect. Dis. [Epub ahead of print], 2014.
[Journal]
5)  Thameem F, Igo RP, Freedman BI, Langefeld C, Hanson RL, Schelling JR, Elston RC, Duggirala R, Nicholas SB, Goddard KA, Divers J, Guo X, Ipp E, Kimmel PL, Meoni LA, Shah VO, Smith MW, Winkler CA, Zager PG, Knowler WC, Nelson RG, Pahl MV, Parekh RS, Kao WH, Rasooly RS, Adler SG, Abboud HE, Iyengar SK, Sedor JR.
A genome-wide search for linkage of estimated glomerular filtration rate (eGFR) in the Family Investigation of Nephropathy and Diabetes (FIND).
PLoS ONE. 8: e81888, 2013.
[Journal]
6)  Parsa A, Kao WH, Xie D, Astor BC, Li M, Hsu CY, Feldman HI, Parekh RS, Kusek JW, Greene TH, Fink JC, Anderson AH, Choi MJ, Wright JT, Lash JP, Freedman BI, Ojo A, Winkler CA, Raj DS, Kopp JB, He J, Jensvold NG, Tao K, Lipkowitz MS, Appel LJ.
APOL1 risk variants, race, and progression of chronic kidney disease.
N. Engl. J. Med. 369: 2183-96, 2013.
[Journal]
7)  McLaren PJ, Coulonges C, Ripke S, van den Berg L, Buchbinder S, Carrington M, Cossarizza A, Dalmau J, Deeks SG, Delaneau O, De Luca A, Goedert JJ, Haas D, Herbeck JT, Kathiresan S, Kirk GD, Lambotte O, Luo M, Mallal S, van Manen D, Martinez-Picado J, Meyer L, Miro JM, Mullins JI, Obel N, O'Brien SJ, Pereyra F, Plummer FA, Poli G, Qi Y, Rucart P, Sandhu MS, Shea PR, Schuitemaker H, Theodorou I, Vannberg F, Veldink J, Walker BD, Weintrob A, Winkler CA, Wolinsky S, Telenti A, Goldstein DB, de Bakker PI, Zagury JF, Fellay J.
Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls.
PLoS Pathog. 9: e1003515, 2013.
[Journal]
8)  Schwarz J, Astermark J, Menius ED, Carrington M, Donfield SM, Gomperts ED, Nelson GW, Oldenburg J, Pavlova A, Shapiro AD, Winkler CA, Berntorp E.
F8 haplotype and inhibitor risk: results from the Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort.
Haemophilia. 19: 113-8, 2013.
[Journal]
9)  Kumar R, Nguyen EA, Roth LA, Oh SS, Gignoux CR, Huntsman S, Eng C, Moreno-Estrada A, Sandoval K, Peñaloza-Espinosa RI, López-López M, Avila PC, Farber HJ, Tcheurekdjian H, Rodriguez-Cintron W, Rodriguez-Santana JR, Serebrisky D, Thyne SM, Williams LK, Winkler C, Bustamante CD, Pérez-Stable EJ, Borrell LN, Burchard EG.
Factors associated with degree of atopy in Latino children in a nationwide pediatric sample: The Genes-environments and Admixture in Latino Asthmatics (GALA II) study.
J. Allergy Clin. Immunol. 132: 896-905, 2013.
[Journal]
10)  Gasser DL, Winkler CA, Peng M, An P, McKenzie LA, Kirk GD, Shi Y, Xie LX, Marbois BN, Clarke CF, Kopp JB.
Focal Segmental Glomerulosclerosis Is Associated With a PDSS2 Haplotype and Independently, With a Decreased Content of Coenzyme Q10.
Am. J. Physiol. Renal Physiol. 305: F1228-38, 2013.
[Journal]
11)  Qi LN, Li LQ, Chen YY, Chen ZH, Bai T, Xiang BD, Qin X, Xiao KY, Peng MH, Liu ZM, Liu TW, Qin X, Li S, Han ZG, Mo ZN, Santella RM, Winkler CA, O'Brien SJ, Peng T.
Genome-wide and differential proteomic analysis of hepatitis B virus and aflatoxin B1 related hepatocellular carcinoma in Guangxi, China.
PLoS ONE. 8: e83465, 2013.
[Journal]
12)  Ko WY, Rajan P, Gomez F, Scheinfeldt L, An P, Winkler CA, Froment A, Nyambo TB, Omar SA, Wambebe C, Ranciaro A, Hirbo JB, Tishkoff SA.
Identifying Darwinian selection acting on different human APOL1 variants among diverse African populations.
Am. J. Hum. Genet. 93: 54-66, 2013.
[Journal]
13)  Astermark J, Donfield SM, Gomperts ED, Schwarz J, Menius ED, Pavlova A, Oldenburg J, Kessing B, DiMichele DM, Shapiro AD, Winkler CA, Berntorp E.
The polygenic nature of inhibitors in hemophilia A: results from the Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort.
Blood. 121: 1446-54, 2013.
[Journal]
14)  Lipkowitz MS, Freedman BI, Langefeld CD, Comeau ME, Bowden DW, Kao WH, Astor BC, Bottinger EP, Iyengar SK, Klotman PE, Freedman RG, Zhang W, Parekh RS, Choi MJ, Nelson GW, Winkler CA, Kopp JB.
Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans.
Kidney Int. 83: 114-20, 2012.
[Journal]
15)  Franceschini N, van Rooij FJ, Prins BP, Feitosa MF, Karakas M, Eckfeldt JH, Folsom AR, Kopp J, Vaez A, Andrews JS, Baumert J, Boraska V, Broer L, Hayward C, Ngwa JS, Okada Y, Polasek O, Westra HJ, Wang YA, Del Greco M F, Glazer NL, Kapur K, Kema IP, Lopez LM, Schillert A, Smith AV, Winkler CA, Zgaga L, Bandinelli S, Bergmann S, Boban M, Bochud M, Chen YD, Davies G, Dehghan A, Ding J, Doering A, Durda JP, Ferrucci L, Franco OH, Franke L, Gunjaca G, Hofman A, Hsu FC, Kolcic I, Kraja A, Kubo M, Lackner KJ, Launer L, Loehr LR, Li G, Meisinger C, Nakamura Y, Schwienbacher C, Starr JM, Takahashi A, Torlak V, Uitterlinden AG, Vitart V, Waldenberger M, Wild PS, Kirin M, Zeller T, Zemunik T, Zhang Q, Ziegler A, Blankenberg S, Boerwinkle E, Borecki IB, Campbell H, Deary IJ, Frayling TM, Gieger C, Harris TB, Hicks AA, Koenig W, O' Donnell CJ, Fox CS, Pramstaller PP, Psaty BM, Reiner AP, Rotter JI, Rudan I, Snieder H, Tanaka T, van Duijn CM, Vollenweider P, Waeber G, Wilson JF, Witteman JC, Wolffenbuttel BH, Wright AF, Wu Q, Liu Y, Jenny NS, North KE, Felix JF, Alizadeh BZ, Cupples LA, Perry JR, Morris AP.
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
Am. J. Hum. Genet. 91: 744-53, 2012.
[Journal]
16)  Zhao K, Ishida Y, Oleksyk TK, Winkler CA, Roca AL.
Evidence for selection at HIV host susceptibility genes in a West Central African human population.
BMC Evol. Biol. 12: 237, 2012.
[Journal]
17)  Kopp JB, Winkler CA.
Genetic risk prediction for CKD: a journey of a thousand miles.
Am. J. Kidney Dis. 59: 4-8, 2012.
[Journal]
18)  Atta MG, Estrella MM, Kuperman M, Foy MC, Fine DM, Racusen LC, Lucas GM, Nelson GW, Warner AC, Winkler CA, Kopp JB.
HIV-associated nephropathy patients with and without apolipoprotein L1 gene variants have similar clinical and pathological characteristics.
Kidney Int. 82: 338-43, 2012.
[Journal]
19)  Limou S, Delaneau O, van Manen D, An P, Sezgin E, Le Clerc S, Coulonges C, Troyer JL, Veldink JH, van den Berg LH, Spadoni JL, Taing L, Labib T, Montes M, Delfraissy JF, Schachter F, O'Brien SJ, Buchbinder S, van Natta ML, Jabs DA, Froguel P, Schuitemaker H, Winkler CA, Zagury JF.
Multicohort genomewide association study reveals a new signal of protection against HIV-1 acquisition.
J. Infect. Dis. 205: 1155-62, 2012.
[Journal]
20)  Wester CW, Eden SK, Shepherd BE, Bussmann H, Novitsky V, Samuels DC, Hendrickson S, Winkler CA, O'Brien SJ, Essex M, D' Aquila RT, Degruttola V, Marlink RG.
Risk Factors for Symptomatic Hyperlactatemia and Lactic Acidosis Among Combination Antiretroviral Therapy-Treated Adults in Botswana: Results From a Clinical Trial.
AIDS Res Hum Retroviruses. 28: 759-65, 2012.
[Journal]
21)  Tang M, Lautenberger JA, Gao X, Sezgin E, Hendrickson SL, Troyer JL, David VA, Guan L, McIntosh CE, Guo X, Zheng Y, Liao J, Deng H, Malasky M, Kessing B, Winkler CA, Carrington M, Dé The G, Zeng Y, O'Brien SJ.
The principal genetic determinants for nasopharyngeal carcinoma in China involve the HLA class I antigen recognition groove.
PLoS Genet. 8: e1003103, 2012.
[Journal]
22)  An P, Winkler C, Guan L, O'Brien SJ, Zeng Z.
A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese.
J. Infect. Dis. 203: 943-7, 2011.
[Journal]
23)  Kopp JB, Nelson GW, Sampath K, Johnson RC, Genovese G, An P, Friedman D, Briggs W, Dart R, Korbet S, Mokrzycki MH, Kimmel PL, Limou S, Ahuja TS, Berns JS, Fryc J, Simon EE, Smith MC, Trachtman H, Michel DM, Schelling JR, Vlahov D, Pollak M, Winkler CA.
APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy.
J. Am. Soc. Nephrol. 22: 2129-37, 2011.
[Journal]
24)  Madlala P, Gijsbers R, Christ F, Hombrouck A, Werner L, Mlisana K, An P, Abdool Karim SS, Winkler CA, Debyser Z, Ndung'u T.
Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression.
AIDS. 25: 1711-9, 2011.
[Journal]
25)  Freedman BI, Langefeld CD, Lu L, Divers J, Comeau ME, Kopp JB, Winkler CA, Nelson GW, Johnson RC, Palmer ND, Hicks PJ, Bostrom MA, Cooke JN, McDonough CW, Bowden DW.
Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African Americans.
PLoS Genet. 7: e1002150, 2011.
[Journal]
26)  Troyer JL, Nelson GW, Lautenberger JA, Chinn L, McIntosh C, Johnson RC, Sezgin E, Kessing B, Malasky M, Hendrickson SL, Li G, Pontius J, Tang M, An P, Winkler CA, Limou S, Le Clerc S, Delaneau O, Zagury JF, Schuitemaker H, van Manen D, Bream JH, Gomperts ED, Buchbinder S, Goedert JJ, Kirk GD, O'Brien SJ.
Genome-wide Association Study Implicates PARD3B-based AIDS Restriction.
J. Infect. Dis. 203: 1491-502, 2011.
[Journal]
27)  Igo RP, Iyengar SK, Nicholas SB, Goddard KA, Langefeld CD, Hanson RL, Duggirala R, Divers J, Abboud H, Adler SG, Arar NH, Horvath A, Elston RC, Bowden DW, Guo X, Ipp E, Kao WH, Kimmel PL, Knowler WC, Meoni LA, Molineros J, Nelson RG, Pahl MV, Parekh RS, Rasooly RS, Schelling JR, Shah VO, Smith MW, Winkler CA, Zager PG, Sedor JR, Freedman BI.
Genomewide Linkage Scan for Diabetic Renal Failure and Albuminuria: The FIND Study.
Am J Nephrol. 33: 381-389, 2011.
[Journal]
28)  An P, Li R, Wang JM, Yoshimura T, Takahashi M, Samudralal R, O'Brien SJ, Phair J, Goedert JJ, Kirk GD, Troyer JL, Sezgin E, Buchbinder SP, Donfield S, Nelson GW, Winkler CA.
Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumonia.
PLoS Genet. 7: e1002328, 2011.
[Journal]
29)  Le Clerc S, Coulonges C, Delaneau O, Van Manen D, Herbeck JT, Limou S, An P, Martinson JJ, Spadoni JL, Therwath A, Veldink JH, van den Berg LH, Taing L, Labib T, Mellak S, Montes M, Delfraissy JF, Schächter F, Winkler C, Froguel P, Mullins JI, Schuitemaker H, Zagury JF.
Screening low-frequency SNPS from genome-wide association study reveals a new risk allele for progression to AIDS.
J. Acquir. Immune Defic. Syndr. 56: 279-84, 2011.
[Journal]
30)  Johnson RC, Nelson GW, Troyer JL, Lautenberger JA, Kessing BD, Winkler CA, O'Brien SJ.
Accounting for multiple comparisons in a genome-wide association study (GWAS).
BMC Genomics. 11: 724, 2010.
[Journal]
31)  Winkler CA, Nelson GW, Smith MW.
Admixture Mapping Comes of Age.
Annu Rev Genomics Hum Genet. 11: 65-89, 2010.
[Journal]
32)  Behar DM, Rosset S, Tzur S, Selig S, Yudkovsky G, Bercovici S, Kopp JB, Winkler CA, Nelson GW, Wasser WG, Skorecki K.
African ancestry allelic variation at the MYH9 gene contributes to increased susceptibility to non-diabetic end-stage kidney disease in Hispanic Americans.
Hum. Mol. Genet. 19: 1816-27, 2010.
[Journal]
33)  Reddy K, Winkler CA, Werner L, Mlisana K, Abdool Karim SS, Ndung'u T.
APOBEC3G expression is dysregulated in primary HIV-1 infection and polymorphic variants influence CD4+ T-cell counts and plasma viral load.
AIDS. 24: 195-204, 2010.
[Journal]
34)  Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, Bowden DW, Langefeld CD, Oleksyk TK, Uscinski Knob AL, Bernhardy AJ, Hicks PJ, Nelson GW, Vanhollebeke B, Winkler CA, Kopp JB, Pays E, Pollak MR.
Association of trypanolytic ApoL1 variants with kidney disease in African Americans.
Science. 329: 841-5, 2010.
[Journal]
35)  Nelson GW, Freedman BI, Bowden DW, Langefeld CD, An P, Hicks PJ, Bostrom MA, Johnson RC, Kopp JB, Winkler CA.
Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15.
Hum. Mol. Genet. 19: 1805-15, 2010.
[Journal]
36)  Winkler CA, Nelson G, Oleksyk TK, Nava MB, Kopp JB.
Genetics of focal segmental glomerulosclerosis and human immunodeficiency virus-associated collapsing glomerulopathy: the role of MYH9 genetic variation.
Semin. Nephrol. 30: 111-25, 2010.
[Journal]
37)  Tang M, Zeng Y, Poisson A, Marti D, Guan L, Zheng Y, Deng H, Liao J, Guo X, Sun S, Nelson G, de Thé G, Winkler CA, O'Brien SJ, Carrington M, Gao X.
Haplotype-dependent HLA susceptibility to nasopharyngeal carcinoma in a Southern Chinese population.
Genes Immun. 11: 334-42, 2010.
[Journal]
38)  An P, Winkler CA.
Host genes associated with HIV/AIDS: advances in gene discovery.
Trends Genet. 26: 119-31, 2010.
[Journal]
39)  Winkler C.
Is there a genetic basis for health disparities in human immunodeficiency virus disease?.
Mt. Sinai J. Med. 77: 149-59, 2010.
[Journal]
40)  Limou S, Coulonges C, Herbeck JT, van Manen D, An P, Le Clerc S, Delaneau O, Diop G, Taing L, Montes M, van't Wout AB, Gottlieb GS, Therwath A, Rouzioux C, Delfraissy JF, Lelièvre JD, Lévy Y, Hercberg S, Dina C, Phair J, Donfield S, Goedert JJ, Buchbinder S, Estaquier J, Schächter F, Gut I, Froguel P, Mullins JI, Schuitemaker H, Winkler C, Zagury JF.
Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS.
J. Infect. Dis. 202: 908-15, 2010.
[Journal]
41)  Herbeck JT, Gottlieb GS, Winkler CA, Nelson GW, An P, Maust BS, Wong KG, Troyer JL, Goedert JJ, Kessing BD, Detels R, Wolinsky SM, Martinson J, Buchbinder S, Kirk GD, Jacobson LP, Margolick JB, Kaslow RA, O'Brien SJ, Mullins JI.
Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS.
J. Infect. Dis. 201: 618-26, 2010.
[Journal]
42)  Kopp JB, Winkler CA, Nelson GW.
MYH9 genetic variants associated with glomerular disease: what is the role for genetic testing?.
Semin. Nephrol. 30: 409-17, 2010.
[Journal]
43)  Freedman BI, Kopp JB, Langefeld CD, Genovese G, Friedman DJ, Nelson GW, Winkler CA, Bowden DW, Pollak MR.
The Apolipoprotein L1 (APOL1) Gene and Nondiabetic Nephropathy in African Americans.
J Am Soc Nephrol. 21: 1422-6, 2010.
[Journal]
44)  Freedman BI, Edberg JC, Comeau ME, Murea M, Bowden DW, Divers J, Alarcón GS, Brown EE, McGwin G, Kopp JB, Winkler CA, Nelson GW, Illei G, Petri M, Ramsey-Goldman R, Reveille JD, Vilá LM, Langefeld CD, Kimberly RP.
The Non-Muscle Myosin Heavy Chain 9 Gene (MYH9) Is Not Associated with Lupus Nephritis in African Americans.
Am J Nephrol. 32: 66-72, 2010.
[Journal]
45)  Oleksyk TK, Nelson GW, An P, Kopp JB, Winkler CA.
Worldwide distribution of the MYH9 kidney disease susceptibility alleles and haplotypes: evidence of historical selection in Africa.
PLoS ONE. 5: e11474, 2010.
[Journal]
46)  An P, Johnson R, Phair J, Kirk GD, Yu X, Donfield S, Buchbinder S, Goedert JJ, Winkler CA.
APOBEC3B Deletion and Risk of HIV-1 Acquisition.
J. Infect. Dis. 200: 1054-8, 2009.
[Journal]
47)  Guo X, Johnson RC, Deng H, Liao J, Guan L, Nelson GW, Tang M, Zheng Y, de The G, O'Brien SJ, Winkler CA, Zeng Y.
Evaluation of nonviral risk factors for nasopharyngeal carcinoma in a high-risk population of Southern China.
Int. J. Cancer. 124: 2942-7, 2009.
[Journal]
48)  Winkler CA, An P, Johnson R, Nelson GW, Kirk G.
Expression of Duffy antigen receptor for chemokines (DARC) has no effect on HIV-1 acquisition or progression to AIDS in African Americans.
Cell Host Microbe. 5: 411-3; author reply 418-9, 2009.
[Journal]
49)  Freedman BI, Hicks PJ, Bostrom MA, Comeau ME, Divers J, Bleyer AJ, Kopp JB, Winkler CA, Nelson GW, Langefeld CD, Bowden DW.
Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD.
Nephrol. Dial. Transplant. 24: 3366-71, 2009.
[Journal]
50)  Freedman BI, Hicks PJ, Bostrom MA, Cunningham ME, Liu Y, Divers J, Kopp JB, Winkler CA, Nelson GW, Langefeld CD, Bowden DW.
Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans.
Kidney Int. 75: 736-45, 2009.
[Journal]
51)  Freedman BI, Kopp JB, Winkler CA, Nelson GW, Rao DC, Eckfeldt JH, Leppert MF, Hicks PJ, Divers J, Langefeld CD, Hunt SC.
Polymorphisms in the Nonmuscle Myosin Heavy Chain 9 Gene (MYH9) Are Associated with Albuminuria in Hypertensive African Americans: The HyperGEN Study.
Am. J. Nephrol. 29: 626-632, 2009.
[Journal]
52)  Nyquist PA, Winkler CA, McKenzie LM, Yanek LR, Becker LC, Becker DM.
Single nucleotide polymorphisms in monocyte chemoattractant protein-1 and its receptor act synergistically to increase the risk of carotid atherosclerosis.
Cerebrovasc. Dis. 28: 124-30, 2009.
[Journal]
53)  Zeng Z, Guan L, An P, Sun S, O'Brien SJ, Winkler CA.
A population-based study to investigate host genetic factors associated with hepatitis B infection and pathogenesis in the Chinese population.
BMC Infect. Dis. 8: 1, 2008.
[Journal]
54)  Hutcheson HB, Lautenberger JA, Nelson GW, Pontius JU, Kessing BD, Winkler CA, Smith MW, Johnson R, Stephens R, Phair J, Goedert JJ, Donfield S, O'Brien SJ.
Detecting AIDS restriction genes: from candidate genes to genome-wide association discovery.
Vaccine. 26: 2951-65, 2008.
[Journal]
55)  Schelling JR, Abboud HE, Nicholas SB, Pahl MV, Sedor JR, Adler SG, Arar NH, Bowden DW, Elston RC, Freedman BI, Goddard KA, Guo X, Hanson RL, Ipp E, Iyengar SK, Jun G, Kao WH, Kasinath BS, Kimmel PL, Klag MJ, Knowler WC, Nelson RG, Parekh RS, Quade SR, Rich SS, Saad MF, Scavini M, Smith MW, Taylor K, Winkler CA, Zager PG, Shah VO.
Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes (FIND).
Diabetes. 57: 235-43, 2008.
[Journal]
56)  Guo X, O'Brien SJ, Zeng Y, Nelson GW, Winkler CA.
GSTM1 and GSTT1 Gene Deletions and the Risk for Nasopharyngeal Carcinoma in Han Chinese.
Cancer Epidemiol. Biomarkers Prev. 17: 1760-3, 2008.
[Journal]
57)  Winkler CA.
Identifying host targets for drug development with knowledge from genome-wide studies: lessons from HIV-AIDS.
Cell Host Microbe. 3: 203-5, 2008.
[Journal]
58)  Thio CL, Astemborski J, Thomas R, Mosbruger T, Witt MD, Goedert JJ, Hoots K, Winkler C, Thomas DL, Carrington M.
Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B.
J. Immunol. 181: 7944-7, 2008.
[Journal]
59)  Kopp JB, Smith MW, Nelson GW, Johnson RC, Freedman BI, Bowden DW, Oleksyk T, McKenzie LM, Kajiyama H, Ahuja TS, Berns JS, Briggs W, Cho ME, Dart RA, Kimmel PL, Korbet SM, Michel DM, Mokrzycki MH, Schelling JR, Simon E, Trachtman H, Vlahov D, Winkler CA.
MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis.
Nat. Genet. 40: 1175-84, 2008.
[Journal]
60)  Kao WH, Klag MJ, Meoni LA, Reich D, Berthier-Schaad Y, Li M, Coresh J, Patterson N, Tandon A, Powe NR, Fink NE, Sadler JH, Weir MR, Abboud HE, Adler SG, Divers J, Iyengar SK, Freedman BI, Kimmel PL, Knowler WC, Kohn OF, Kramp K, Leehey DJ, Nicholas SB, Pahl MV, Schelling JR, Sedor JR, Thornley-Brown D, Winkler CA, Smith MW, Parekh RS.
MYH9 is associated with nondiabetic end-stage renal disease in African Americans.
Nat. Genet. 40: 1185-92, 2008.
[Journal]
61)  An P, Thio CL, Kirk GD, Donfield S, Goedert JJ, Winkler CA.
Regulatory Polymorphisms in the Interleukin-18 Promoter Are Associated with Hepatitis C Virus Clearance.
J. Infect. Dis. 198: 1159-1165, 2008.
[Journal]
62)  Price AL, Patterson N, Yu F, Cox DR, Waliszewska A, McDonald GJ, Tandon A, Schirmer C, Neubauer J, Bedoya G, Duque C, Villegas A, Bortolini MC, Salzano FM, Gallo C, Mazzotti G, Tello-Ruiz M, Riba L, Aguilar-Salinas CA, Canizales-Quinteros S, Menjivar M, Klitz W, Henderson B, Haiman CA, Winkler C, Tusie-Luna T, Ruiz-Linares A, Reich D.
A genomewide admixture map for Latino populations.
Am. J. Hum. Genet. 80: 1024-36, 2007.
[Journal]
63)  Iyengar SK, Abboud HE, Goddard KA, Saad MF, Adler SG, Arar NH, Bowden DW, Duggirala R, Elston RC, Hanson RL, Ipp E, Kao WH, Kimmel PL, Klag MJ, Knowler WC, Meoni LA, Nelson RG, Nicholas SB, Pahl MV, Parekh RS, Quade SR, Rich SS, Rotter JI, Scavini M, Schelling JR, Sedor JR, Sehgal AR, Shah VO, Smith MW, Taylor KD, Winkler CA, Zager PG, Freedman BI.
Genome-Wide Scans for Diabetic Nephropathy and Albuminuria in Multi-Ethnic Populations: The Family Investigation of Nephropathy and Diabetes.
Diabetes. 56: 1577-85, 2007.
[Journal]
64)  McKenzie LM, Hendrickson SL, Briggs WA, Dart RA, Korbet SM, Mokrzycki MH, Kimmel PL, Ahuja TS, Berns JS, Simon EE, Smith MC, Trachtman H, Michel DM, Schelling JR, Cho M, Zhou YC, Binns-Roemer E, Kirk GD, Kopp JB, Winkler CA.
NPHS2 variation in sporadic focal segmental glomerulosclerosis.
J. Am. Soc. Nephrol. 18: 2987-95, 2007.
[Journal]
65)  An P, Duggal P, Wang LH, O'Brien SJ, Donfield S, Goedert JJ, Phair J, Buchbinder S, Kirk GD, Winkler CA.
Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individuals.
PLoS Genet. 3: e19, 2007.
[Journal]
66)  An P, Wang LH, Hutcheson-Dilks H, Nelson G, Donfield S, Goedert JJ, Rinaldo CR, Buchbinder S, Kirk GD, O'Brien SJ, Winkler CA.
Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS.
PLoS Pathog. 3: e88, 2007.
[Journal]
67)  Li X, Gold B, O'hUigin C, Diaz-Griffero F, Song B, Si Z, Li Y, Yuan W, Stremlau M, Mische C, Javanbakht H, Scally M, Winkler C, Dean M, Sodroski J.
Unique features of TRIM5alpha among closely related human TRIM family members.
Virology. 360: 419-33, 2007.
[Journal]
68)  Guo XC, O'Brien SJ, Winkler C, Scott K, Hutcheson H, David V, Kessing B, Zheng YM, Liao J, Lui Y, Guy de T, Zeng Y.
[Association study of chromosome 4 STRs polymorphisms with nasopharyngeal carcinoma].
Yi Chuan. 28: 783-90, 2006.
[Journal]
69)  Javanbakht H, An P, Gold B, Petersen DC, O'huigin C, Nelson GW, O'brien SJ, Kirk GD, Detels R, Buchbinder S, Donfield S, Shulenin S, Song B, Perron MJ, Stremlau M, Sodroski J, Dean M, Winkler C.
Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection.
Virology. 354: 15-27, 2006.
[Journal]
70)  Guo XC, Scott K, Liu Y, Dean M, David V, Nelson GW, Johnson RC, Dilks HH, Lautenberger J, Kessing B, Martenson J, Guan L, Sun S, Deng H, Zheng Y, de The G, Liao J, Zeng Y, O'Brien SJ, Winkler CA.
Genetic factors leading to chronic Epstein-Barr virus infection and nasopharyngeal carcinoma in South East China: study design, methods and feasibility.
Hum. Genomics. 2: 365-75, 2006.
[Journal]
71)  Modi WS, Lautenberger J, An P, Scott K, Goedert JJ, Kirk GD, Buchbinder S, Phair J, Donfield S, O'brien SJ, Winkler C.
Genetic Variation in the CCL18-CCL3-CCL4 Chemokine Gene Cluster Influences HIV Type 1 Transmission and AIDS Disease Progression.
Am. J. Hum. Genet. 79: 120-8, 2006.
[Journal]
72)  Franceschini N, North KE, Kopp JB, McKenzie L, Winkler C.
NPHS2 gene, nephrotic syndrome and focal segmental glomerulosclerosis: a HuGE review.
Genet. Med. 8: 63-75, 2006.
[Journal]
73)  Walsh EC, Sabeti P, Hutcheson HB, Fry B, Schaffner SF, de Bakker PI, Varilly P, Palma AA, Roy J, Cooper R, Winkler C, Zeng Y, de The G, Lander ES, O'brien S, Altshuler D.
Searching for signals of evolutionary selection in 168 genes related to immune function.
Human Genetics. 119(1-2):92-102, 2006.
[Journal]
74)  Berntorp E, Astermark J, Donfield SM, Nelson GW, Oldenburg J, Shapiro AD, Dimichele DM, Ewenstein BM, Gomperts ED, Winkler CA.
Haemophilia Inhibitor Genetics Study - evaluation of a model for studies of complex diseases using linkage and association methods.
Haemophilia. 11: 427-9, 2005.
[Journal]
75)  Modi WS, Scott K, Goedert JJ, Vlahov D, Buchbinder S, Detels R, Donfield S, O'brien SJ, Winkler C.
Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study.
Genes and Immunity. 1-8, 2005.
[Journal]
76)  Daar E, Lynn H, Donfield S, Lail A, O'Brien S, Huang W, Winkler C.
Stromal cell-derived factor-1 genotype, co-receptor tropism and human immunodeficiency virus type 1 progression.
J. Virol. 192: 1597-1605, 2005.
[Journal]
77)  Daar ES, Lynn HS, Donfield SM, Lail A, O'Brien SJ, Huang W, Winkler CA.
Stromal cell-derived factor-1 genotype, coreceptor tropism, and HIV type 1 disease progression.
J. Infect. Dis. 192: 1597-605, 2005.
[Journal]
78)  Song B, Gold B, O'Huigin C, Javanbakht H, Li X, Stremlau M, Winkler C, Dean M, Sodroski J.
The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates.
J. Virol. 79: 6111-21, 2005.
[Journal]
79)  Duggal P, Winkler CA, An P, Yu XF, Farzadegan H, O'Brien SJ, Beaty TH, Vlahov D.
The effect of RANTES chemokine genetic variants on early HIV-1 plasma RNA among African American injection drug users.
J. Acquir. Immune Defic. Syndr. 38: 584-9, 2005.
[Journal]
80)  Orloff MS, Iyengar SK, Winkler CA, Goddard KA, Dart RA, Ahuja TS, Mokrzycki M, Briggs WA, Korbet SM, Kimmel PL, Simon EE, Trachtman H, Vlahov D, Michel DM, Berns JS, Smith MC, Schelling JR, Sedor JR, Kopp JB.
Variants in the Wilms' tumor gene are associated with focal segmental glomerulosclerosis in the African American population.
Physiol. Genomics. 21: 212-21, 2005.
[Journal]
81)  Smith MW, Patterson N, Lautenberger JA, Truelove AL, McDonald GJ, Waliszewska A, Kessing BD, Malasky MJ, Scafe C, Le E, De Jager PL, Mignault AA, Yi Z, De The G, Essex M, Sankale JL, Moore JH, Poku K, Phair JP, Goedert JJ, Vlahov D, Williams SM, Tishkoff SA, Winkler CA, De La Vega FM, Woodage T, Sninsky JJ, Hafler DA, Altshuler D, Gilbert DA, O'Brien SJ, Reich D.
A high-density admixture map for disease gene discovery in african americans.
Am. J. Hum. Genet. 74: 1001-13, 2004.
[Journal]
82)  An P, Bleiber G, Duggal P, Nelson G, May M, Mangeat B, Alobwede I, Trono D, Vlahov D, Donfield S, Goedert JJ, Phair J, Buchbinder S, O'Brien SJ, Telenti A, Winkler CA.
APOBEC3G genetic variants and their influence on the progression to AIDS.
J. Virol. 78: 11070-6, 2004.
[Journal]
83)  Winkler CA, Hendel H, Carrington M, Smith MW, Nelson GW, O'brien SJ, Phair J, Vlahov D, Jacobson LP, Rappaport J, Vasilescu A, Bertin-Maghit S, An P, Lu W, Andrieu JM, Schächter F, Therwath A, Zagury JF.
Dominant effects of CCR2-CCR5 haplotypes in HIV-1 disease progression.
J. Acquir. Immune Defic. Syndr. 37: 1534-8, 2004.
[Journal]
84)  Winkler C, An P, O'Brien SJ.
Patterns of ethnic diversity among the genes that influence AIDS.
Hum. Mol. Genet. 13 Spec No 1: R9-19, 2004.
[Journal]
85)  An P, Vlahov D, Margolick JB, Phair J, O'Brien TR, Lautenberger J, O'Brien SJ, Winkler CA.
A tumor necrosis factor-alpha-inducible promoter variant of interferon-gamma accelerates CD4+ T cell depletion in human immunodeficiency virus-1-infected individuals.
J. Infect. Dis. 188: 228-31, 2003.
[Journal]
86)  Kim JM, Wu H, Green G, Winkler CA, Kopp JB, Miner JH, Unanue ER, Shaw AS.
CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility.
Science. 300: 1298-300, 2003.
[Journal]
87)  Duggal P, An P, Beaty TH, Strathdee SA, Farzadegan H, Markham RB, Johnson L, O'Brien SJ, Vlahov D, Winkler CA.
Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans.
Genes Immun. 4: 245-50, 2003.
[Journal]
88)  Modi WS, O'Brien TR, Vlahov D, Buchbinder S, Gomperts E, Phair J, O'Brien SJ, Winkler C.
Haplotype diversity in the interleukin-4 gene is not associated with HIV-1 transmission and AIDS progression.
Immunogenetics. 55: 157-64, 2003.
[Journal]
89)  Kopp JB, Winkler C.
HIV-associated nephropathy in African Americans.
Kidney Int. Suppl. S43-9, 2003.
[Journal]
90)  Modi WS, Goedert JJ, Strathdee S, Buchbinder S, Detels R, Donfield S, O'Brien SJ, Winkler C.
MCP-1-MCP-3-Eotaxin gene cluster influences HIV-1 transmission.
AIDS. 17: 2357-65, 2003.
[Journal]
91)  Wang FS, Hong WG, Cao Y, Liu MX, Jin L, Hu LP, Wang Z, Feng TJ, Hou J, Zhang B, Shi M, Xu DP, Lei ZY, Wang B, Liu ZD, Ye JJ, Peng L, Qiu Y, Winkler C.
Population survey of CCR5 delta32, CCR5 m303, CCR2b 64I, and SDF1 3'A allele frequencies in indigenous Chinese healthy individuals, and in HIV-1-infected and HIV-1-uninfected individuals in HIV-1 risk groups.
J. Acquir. Immune Defic. Syndr. 32: 124-30, 2003.
[Journal]
92)  Bream JH, Ping A, Zhang X, Winkler C, Young HA.
A single nucleotide polymorphism in the proximal IFN-gamma promoter alters control of gene transcription.
Genes Immun. 3: 165-9, 2002.
[Journal]
93)  An P, Nelson GW, Wang L, Donfield S, Goedert JJ, Phair J, Vlahov D, Buchbinder S, Farrar WL, Modi W, O'Brien SJ, Winkler CA.
Modulating influence on HIV/AIDS by interacting RANTES gene variants.
Proc. Natl. Acad. Sci. U.S.A. 99: 10002-7, 2002.
[Journal]
94)  Daar ES, Lynn H, Donfield S, Gomperts E, O'Brien SJ, Hilgartner MW, Hoots WK, Chernoff D, Arkin S, Wong WY, Winkler CA.
Hepatitis C virus load is associated with human immunodeficiency virus type 1 disease progression in hemophiliacs.
J. Infect. Dis. 183: 589-95, 2001.
[Journal]
95)  Hollenbach JA, Thomson G, Cao K, Fernandez-Vina M, Erlich HA, Bugawan TL, Winkler C, Winter M, Klitz W.
HLA diversity, differentiation, and haplotype evolution in Mesoamerican Natives.
Hum. Immunol. 62: 378-90, 2001.
[Journal]
96)  Daar ES, Lynn H, Donfield S, Gomperts E, Hilgartner MW, Hoots WK, Chernoff D, Arkin S, Wong WY, Winkler CA.
Relation between HIV-1 and hepatitis C viral load in patients with hemophilia.
J. Acquir. Immune Defic. Syndr. 26: 466-72, 2001.
[Journal]
97)  Hendel H, Winkler C, An P, Roemer-Binns E, Nelson G, Haumont P, O'Brien S, Khalilli K, Zagury D, Rappaport J, Zagury JF.
Validation of genetic case-control studies in AIDS and application to the CX3CR1 polymorphism.
J. Acquir. Immune Defic. Syndr. 26: 507-11, 2001.
[Journal]
98)  An P, Luo H, Lu T, O'Brien SJ, Winkler C.
Genetic heterogeneity and molecular epidemiology of GB virus C/hepatitis G virus in China.
J. Hum. Virol. 3: 299-305, 2000.
[Journal]
99)  Shin HD, Winkler C, Stephens JC, Bream J, Young H, Goedert JJ, O'Brien TR, Vlahov D, Buchbinder S, Giorgi J, Rinaldo C, Donfield S, Willoughby A, O'Brien SJ, Smith MW.
Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10.
Proc. Natl. Acad. Sci. U.S.A. 97: 14467-72, 2000.
[Journal]
100)  An P, Martin MP, Nelson GW, Carrington M, Smith MW, Gong K, Vlahov D, O'Brien SJ, Winkler CA.
Influence of CCR5 promoter haplotypes on AIDS progression in African-Americans.
AIDS. 14: 2117-22, 2000.
[Journal]
101)  O'Brien SJ, Nelson GW, Winkler CA, Smith MW.
Polygenic and multifactorial disease gene association in man: Lessons from AIDS.
Annu. Rev. Genet. 34: 563-591, 2000.
[Journal]
102)  Daar ES, Lynn H, Donfield S, Gomperts E, Hilgartner MW, Hoots K, Chernoff D, Winkler C, O'Brien SJ.
Effects of plasma HIV RNA, CD4+ T lymphocytes, and the chemokine receptors CCR5 and CCR2b on HIV disease progression in hemophiliacs. Hemophilia Growth and Development Study.
J. Acquir. Immune Defic. Syndr. 21: 317-25, 1999.
[Journal]
103)  Hendel H, Caillat-Zucman S, Lebuanec H, Carrington M, O'Brien S, Andrieu JM, Schächter F, Zagury D, Rappaport J, Winkler C, Nelson GW, Zagury JF.
New class I and II HLA alleles strongly associated with opposite patterns of progression to AIDS.
J. Immunol. 162: 6942-6, 1999.
[Journal]
104)  Stephens JC, Reich DE, Goldstein DB, Shin HD, Smith MW, Carrington M, Winkler C, Huttley GA, Allikmets R, Schriml L, Gerrard B, Malasky M, Ramos MD, Morlot S, Tzetis M, Oddoux C, di Giovine FS, Nasioulas G, Chandler D, Aseev M, Hanson M, Kalaydjieva L, Glavac D, Gasparini P, Kanavakis E, Claustres M, Kambouris M, Ostrer H, Duff G, Baranov V, Sibul H, Metspalu A, Goldman D, Martin N, Duffy D, Schmidtke J, Estivill X, O'Brien SJ, Dean M.
Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes.
Am. J. Hum. Genet. 62: 1507-15, 1998.
[Journal]
105)  Hendel H, Hénon N, Lebuanec H, Lachgar A, Poncelet H, Caillat-Zucman S, Winkler CA, Smith MW, Kenefic L, O'Brien S, Lu W, Andrieu JM, Zagury D, Schächter F, Rappaport J, Zagury JF.
Distinctive effects of CCR5, CCR2, and SDF1 genetic polymorphisms in AIDS progression.
J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 19: 381-6, 1998.
[Journal]
106)  Winkler C, Modi W, Smith MW, Nelson GW, Wu X, Carrington M, Dean M, Honjo T, Tashiro K, Yabe D, Buchbinder S, Vittinghoff E, Goedert JJ, O'Brien TR, Jacobson LP, Detels R, Donfield S, Willoughby A, Gomperts E, Vlahov D, Phair J, O'Brien SJ.
Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC).
Science. 279: 389-93, 1998.
[Journal]
107)  Smith MW, Carrington M, Winkler C, Lomb D, Dean M, Huttley G, O'Brien SJ.
CCR2 chemokine receptor and AIDS progression.
Nat. Med. 3: 1052-3, 1997.
[Journal]
108)  Smith MW, Dean M, Carrington M, Winkler C, Huttley GA, Lomb DA, Goedert JJ, O'Brien TR, Jacobson LP, Kaslow R, Buchbinder S, Vittinghoff E, Vlahov D, Hoots K, Hilgartner MW, O'Brien SJ.
Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study.
Science. 277: 959-65, 1997.
[Journal]
109)  An P, Wei L, Wu X, Yuhki N, O'Brien SJ, Winkler C.
Evolutionary analysis of the 5'-terminal region of hepatitis G virus isolated from different regions in China.
J. Gen. Virol. 78 ( Pt 10): 2477-82, 1997.
[Journal]
110)  O'Brien TR, Winkler C, Dean M, Nelson JA, Carrington M, Michael NL, White GC.
HIV-1 infection in a man homozygous for CCR5 delta 32.
Lancet. 349: 1219, 1997.
[Journal]
111)  Dean M, Carrington M, Winkler C, Huttley GA, Smith MW, Allikmets R, Goedert JJ, Buchbinder SP, Vittinghoff E, Gomperts E, Donfield S, Vlahov D, Kaslow R, Saah A, Rinaldo C, Detels R, O'Brien SJ.
Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study.
Science. 273: 1856-62, 1996.
[Journal]
112)  Kaslow RA, Carrington M, Apple R, Park L, Muñoz A, Saah AJ, Goedert JJ, Winkler C, O'Brien SJ, Rinaldo C, Detels R, Blattner W, Phair J, Erlich H, Mann DL.
Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection.
Nat. Med. 2: 405-11, 1996.
[Journal]
113)  Dean M, Stephens JC, Winkler C, Lomb DA, Ramsburg M, Boaze R, Stewart C, Charbonneau L, Goldman D, Albaugh BJ.
Polymorphic admixture typing in human ethnic populations.
Am. J. Hum. Genet. 55: 788-808, 1994.
[Journal]
114)  Winkler C, Schultz A, Cevario S, O'Brien S.
Genetic characterization of FLA, the cat major histocompatibility complex.
Proc. Natl. Acad. Sci. U.S.A. 86: 943-7, 1989.
[Journal]
115)  O'Brien SJ, Haskins ME, Winkler CA, Nash WG, Patterson DF.
Chromosomal mapping of beta-globin and albino loci in the domestic cat. A conserved mammalian chromosome group.
J. Hered. 77: 374-8, 1986.
[Journal]
116)  O'Brien SJ, Roelke ME, Marker L, Newman A, Winkler CA, Meltzer D, Colly L, Evermann JF, Bush M, Wildt DE.
Genetic basis for species vulnerability in the cheetah.
Science. 227: 1428-34, 1985.
[Journal]
117)  O'Brien SJ, Nash WG, Winkler CA, Reeves RH.
Genetic analysis in the domestic cat as an animal model for inborn errors, cancer and evolution.
Prog. Clin. Biol. Res. 94: 67-90, 1982.
[Journal]
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