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Our Science – Young Website

Howard A. Young, Ph.D.

Selected Publications

1)  Hodge DL, Berthet C, Coppola V, Kastenmüller W, Buschman MD, Schaughency PM, Shirota H, Scarzello AJ, Subleski JJ, Anver MR, Ortaldo JR, Lin F, Reynolds DA, Sanford ME, Kaldis P, Tessarollo L, Klinman DM, Young HA.
IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice.
J. Autoimmun. [Epub ahead of print], 2014.
2)  McFarland AP, Savan R, Wagage S, Addison A, Ramakrishnan K, Karwan M, Duong T, Young HA.
Localized delivery of interferon-beta by Lactobacillus exacerbates experimental colitis.
PLoS ONE. 6: e16967, 2011.
3)  Savan R, McFarland AP, Reynolds DA, Feigenbaum L, Ramakrishnan K, Karwan M, Shirota H, Klinman DM, Dunleavy K, Pittaluga S, Anderson SK, Donnelly RP, Wilson WH, Young HA.
A novel role for IL-22R1 as a driver of inflammation.
Blood. 117: 575-84, 2011.
4)  Ortaldo JR, Winkler-Pickett R, Wigginton J, Horner M, Bere EW, Mason AT, Bhat N, Cherry J, Sanford M, Hodge DL, Young HA.
Regulation of ITAM-positive receptors: role of IL-12 and IL-18.
Blood. 107: 1468-75, 2006.
5)  Hodge DL, Martinez A, Julias JG, Taylor LS, Young HA.
Regulation of nuclear gamma interferon gene expression by interleukin 12 (IL-12) and IL-2 represents a novel form of posttranscriptional control.
Mol Cell Biol. 22: 1742-1753, 2002.
6)  Barrios B, Baez NS, Reynolds D, Iribarren P, Cejas H, Young HA, Rodriguez-Galan MC.
Abrogation of TNFa Production during Cancer Immunotherapy Is Crucial for Suppressing Side Effects Due to the Systemic Expression of IL-12.
PLoS ONE. 9: e90116, 2014.
7)  Lee YJ, Zhang X, Vazquez E, Shivasabesan G, Young HA, Murphy A, Wang H, Suffredini AF, Siebenlist U, Kottilil S.
Impaired HCV clearance in HIV/HCV coinfected subjects treated with PegIFN and RBV due to interference of IFN signaling by IFNaR2a.
J. Interferon Cytokine Res. 34: 28-34, 2014.
8)  Heinecke JL, Ridnour LA, Cheng RY, Switzer CH, Lizardo MM, Khanna C, Glynn SA, Hussain SP, Young HA, Ambs S, Wink DA.
Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression.
Proc. Natl. Acad. Sci. U.S.A. 111: 6323-8, 2014.
9)  Smith LM, Hensley LE, Geisbert TW, Johnson J, Stossel A, Honko A, Yen JY, Geisbert J, Paragas J, Fritz E, Olinger G, Young HA, Rubins KH, Karp CL.
Interferon-ß Therapy Prolongs Survival in Rhesus Macaque Models of Ebola and Marburg Hemorrhagic Fever.
J. Infect. Dis. 208: 310-8, 2013.
10)  Xiao Z, Jiang Q, Willette-Brown J, Xi S, Zhu F, Burkett S, Back T, Song NY, Datla M, Sun Z, Goldszmid R, Lin F, Cohoon T, Pike K, Wu X, Schrump DS, Wong KK, Young HA, Trinchieri G, Wiltrout RH, Hu Y.
The Pivotal Role of IKKa in the Development of Spontaneous Lung Squamous Cell Carcinomas.
Cancer Cell. 23: 527-40, 2013.
11)  Kawayama T, Okamoto M, Imaoka H, Kato S, Young HA, Hoshino T.
Interleukin-18 in pulmonary inflammatory diseases.
J. Interferon Cytokine Res. 32: 443-9, 2012.
12)  Hodge DL, Reynolds D, Cerbán FM, Correa SG, Baez NS, Young HA, Rodriguez-Galan MC.
MCP-1/CCR2 interactions direct migration of peripheral B and T lymphocytes to the thymus during acute infectious/inflammatory processes.
Eur. J. Immunol. 42: 2644-54, 2012.
13)  Ridnour LA, Cheng RY, Switzer CH, Heinecke JL, Ambs S, Glynn SA, Young HA, Trinchieri G, Wink DA.
Molecular Pathways: Toll-like Receptors in the Tumor Microenvironment: Poor Prognosis or New Therapeutic Opportunity.
Clin. Cancer Res. 19: 1340-6, 2012.
14)  Xiao C, Wang RH, Lahusen TJ, Park O, Bertola A, Maruyama T, Reynolds D, Chen Q, Xu X, Young HA, Chen WJ, Gao B, Deng CX.
Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice.
J. Biol. Chem. 287: 41903-13, 2012.
15)  Young HA.
Scientific Apps are here (and more will be coming).
Cytokine. 59: 1-2, 2012.
16)  Zhang X, Brann TW, Zhou M, Yang J, Oguariri RM, Lidie KB, Imamichi H, Huang DW, Lempicki RA, Baseler MW, Veenstra TD, Young HA, Lane HC, Imamichi T.
Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN.
J. Immunol. 186: 4541-5, 2011.
17)  Kulkarni S, Savan R, Qi Y, Gao X, Yuki Y, Bass SE, Martin MP, Hunt P, Deeks SG, Telenti A, Pereyra F, Goldstein D, Wolinsky S, Walker B, Young HA, Carrington M.
Differential microRNA regulation of HLA-C expression and its association with HIV control.
Nature. 472: 495-8, 2011.
18)  Zhu Y, Michelle Luo T, Jobin C, Young HA.
Gut microbiota and probiotics in colon tumorigenesis.
Cancer Lett. 309: 119-27, 2011.
19)  Park O, Wang H, Weng H, Feigenbaum L, Li H, Yin S, Ki S, Yoo SH, Dooley S, Wang F, Young HA, Gao B.
In vivo consequences of liver-specific interleukin-22 expression: Implications for human liver disease progression.
Hepatology. 54: 252-61, 2011.
20)  Zaidi MR, Davis S, Noonan FP, Graff-Cherry C, Hawley TS, Walker RL, Feigenbaum L, Fuchs E, Lyakh L, Young HA, Hornyak TJ, Arnheiter H, Trinchieri G, Meltzer PS, De Fabo EC, Merlino G.
Interferon-gamma links ultraviolet radiation to melanomagenesis in mice.
Nature. 469: 548-53, 2011.
21)  Kaczmarczyk SJ, Sitaraman K, Young HA, Hughes SH, Chatterjee DK.
Protein delivery using engineered virus-like particles.
Proc. Natl. Acad. Sci. U.S.A. 108: 16998-7003, 2011.
22)  Donnelly RP, Sheikh F, Dickensheets H, Savan R, Young HA, Walter MR.
Interleukin-26: an IL-10-related cytokine produced by Th17 cells.
Cytokine Growth Factor Rev. 21: 393-401, 2010.
23)  Savan R, Chan T, Young HA.
Lentiviral gene transduction in human and mouse NK cell lines.
Methods Mol. Biol. 612: 209-21, 2010.
24)  Klein M, Sanders ME, Duong T, Young HA.
Probiotics: from bench to market.
Ann. N. Y. Acad. Sci. 1212 Suppl 1: E1-14, 2010.
25)  Donnelly RP, Young HA, Rosenberg AS.
An overview of cytokines and cytokine antagonists as therapeutic agents.
Ann. N. Y. Acad. Sci. 1182: 1-13, 2009.
26)  Cismasiu VB, Duque J, Paskaleva E, Califano D, Ghanta S, Young HA, Avram D.
BCL11B enhances TCR/CD28-triggered NF-kappaB activation through up-regulation of Cot kinase gene expression in T-lymphocytes.
Biochem. J. 417: 457-66, 2009.
27)  Miller CH, Maher SG, Young HA.
Clinical Use of Interferon-gamma.
Ann. N. Y. Acad. Sci. 1182: 69-79, 2009.
28)  Rodriguez-Galan MC, Reynolds D, Correa SG, Iribarren P, Watanabe M, Young HA.
Coexpression of IL-18 strongly attenuates IL-12-induced systemic toxicity through a rapid induction of IL-10 without affecting its antitumor capacity.
J. Immunol. 183: 740-8, 2009.
29)  Young HA.
Cytokine multiplex analysis.
Methods Mol. Biol. 511: 85-105, 2009.
30)  Hodge DL, Yang J, Buschman MD, Schaughency PM, Dang H, Bere W, Yang Y, Savan R, Subleski JJ, Yin XM, Loughran TP, Young HA.
Interleukin-15 enhances proteasomal degradation of bid in normal lymphocytes: implications for large granular lymphocyte leukemias.
Cancer Res. 69: 3986-94, 2009.
31)  Hoshino T, Okamoto M, Sakazaki Y, Kato S, Young HA, Aizawa H.
Role of Proinflammatory Cytokine IL-18 and IL-1{beta} in Bleomycin-induced Lung Injury in Humans and Mice.
Am. J. Respir. Cell Mol. Biol. 41: 661-70, 2009.
32)  Savan R, Ravichandran S, Collins JR, Sakai M, Young HA.
Structural conservation of interferon gamma among vertebrates.
Cytokine Growth Factor Rev. 20: 115-24, 2009.
33)  Duan D, Sigano DM, Kelley JA, Lai CC, Lewin NE, Kedei N, Peach ML, Lee J, Abeyweera TP, Rotenberg SA, Kim H, Kim YH, El Kazzouli S, Chung JU, Young HA, Young MR, Baker A, Colburn NH, Haimovitz-Friedman A, Truman JP, Parrish DA, Deschamps JR, Perry NA, Surawski RJ, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities.
J. Med. Chem. 51: 5198-220, 2008.
34)  Winkler-Pickett R, Young HA, Cherry JM, Diehl J, Wine J, Back T, Bere WE, Mason AT, Ortaldo JR.
In vivo regulation of experimental autoimmune encephalomyelitis by NK cells: alteration of primary adaptive responses.
J. Immunol. 180: 4495-506, 2008.
35)  Biragyn A, Coscia M, Nagashima K, Sanford M, Young HA, Olkhanud P.
Murine beta-defensin 2 promotes TLR-4/MyD88-mediated and NF-kappaB-dependent atypical death of APCs via activation of TNFR2.
J. Leukoc. Biol. 83: 998-1008, 2008.
36)  Chakrabarti A, Sadler AJ, Kar N, Young HA, Silverman RH, Williams BR.
Protein kinase R-dependent regulation of interleukin-10 in response to double-stranded RNA.
J. Biol. Chem. 283: 25132-9, 2008.
37)  Caposio P, Gugliesi F, Zannetti C, Sponza S, Mondini M, Medico E, Hiscott J, Young HA, Gribaudo G, Gariglio M, Landolfo S.
A novel role of the interferon-inducible protein IFI16 as inducer of proinflammatory molecules in endothelial cells.
J. Biol. Chem. 282: 33515-29, 2007.
38)  Berthet C, Rodriguez-Galan MC, Hodge DL, Gooya J, Pascal V, Young HA, Keller J, Bosselut R, Kaldis P.
Hematopoiesis and thymic apoptosis are not affected by the loss of cdk2.
Mol. Cell. Biol. 27: 5079-89, 2007.
39)  Young HA, Bream JH.
IFN-gamma: recent advances in understanding regulation of expression, biological functions, and clinical applications.
Curr. Top. Microbiol. Immunol. 316: 97-117, 2007.
40)  Geisbert TW, Daddario-DiCaprio KM, Geisbert JB, Young HA, Formenty P, Fritz EA, Larsen T, Hensley LE.
Marburg virus Angola infection of rhesus macaques: pathogenesis and treatment with recombinant nematode anticoagulant protein c2.
J. Infect. Dis. 196 Suppl 2: S372-81, 2007.
41)  Ortaldo JR, Mason A, Willette-Brown J, Ruscetti FW, Wine J, Back T, Stull T, Bere EW, Feigenbaum L, Winkler-Pickett R, Young HA.
Modulation of lymphocyte function with inhibitory CD2: loss of NK and NKT cells.
Cell. Immunol. 249: 8-19, 2007.
42)  Sonoda KH, Nakamura T, Young HA, Hart D, Carmeliet P, Stein-Streilein J.
NKT cell-derived urokinase-type plasminogen activator promotes peripheral tolerance associated with eye.
J. Immunol. 179: 2215-22, 2007.
43)  Hoshino T, Kato S, Oka N, Imaoka H, Kinoshita T, Takei S, Kitasato Y, Kawayama T, Imaizumi T, Yamada K, Young HA, Aizawa H.
Pulmonary Inflammation and Emphysema: Role of the Cytokines IL-18 and IL-13.
Am. J. Respir. Crit. Care Med. 176: 49-62, 2007.
44)  Roberts ZJ, Goutagny N, Perera P, Kato H, Kumar H, Kawai T, Akira S, Savan R, van Echo D, Fitzgerald KA, Young HA, Ching L, Vogel SN.
The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis.
J. Exp. Med. 204: 1559-69, 2007.
45)  Rubins KH, Hensley LE, Wahl-Jensen V, Daddario DiCaprio KM, Young HA, Reed DS, Jahrling PB, Brown PO, Relman DA, Geisbert TW.
The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever.
Genome Biol. 8: R174, 2007.
46)  Gonsky R, Deem RL, Bream JH, Young HA, Targan SR.
An IFNG SNP with an estrogen-like response element selectively enhances promoter expression in peripheral but not lamina propria T cells.
Genes Immun. 7: 342-51, 2006.
47)  Kogkopoulou O, Tzakos E, Mavrothalassitis G, Baldari CT, Paliogianni F, Young HA, Thyphronitis G.
Conditional up-regulation of IL-2 production by p38 MAPK inactivation is mediated by increased Erk1/2 activity.
J. Leukoc. Biol. 79: 1052-60, 2006.
48)  Young HA, Ortaldo J.
Cytokines as critical co-stimulatory molecules in modulating the immune response of natural killer cells.
Cell Res. 16: 20-4, 2006.
49)  Ortaldo JR, Young HA.
IL-18 as critical co-stimulatory molecules in modulating the immune response of ITAM bearing lymphocytes.
Semin. Immunol. 18: 193-6, 2006.
50)  Feng CG, Kaviratne M, Rothfuchs AG, Cheever A, Hieny S, Young HA, Wynn TA, Sher A.
NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis.
J. Immunol. 177: 7086-93, 2006.
51)  Adachi M, Kurotani R, Morimura K, Shah Y, Sanford M, Madison BB, Gumucio DL, Marin HE, Peters JM, Young HA, Gonzalez FJ.
Peroxisome proliferator activated receptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease.
Gut. 55: 1104-13, 2006.
52)  Khabar KS, Young HA.
Post-transcriptional control of the interferon system.
Biochimie. 89: 761-9, 2006.
53)  Hodge DL, Subleski JJ, Reynolds DA, Buschman MD, Schill WB, Burkett MW, Malyguine AM, Young HA.
The proinflammatory cytokine interleukin-18 alters multiple signaling pathways to inhibit natural killer cell death.
J. Interferon Cytokine Res. 26: 706-18, 2006.
54)  Coppola V, Barrick CA, Bobisse S, Rodriguez-Galan MC, Pivetta M, Reynolds D, Howard OM, Palko ME, Esteban PF, Young HA, Rosato A, Tessarollo L.
The scaffold protein Cybr is required for cytokine-modulated trafficking of leukocytes in vivo.
Mol. Cell. Biol. 26: 5249-58, 2006.
55)  Young HA, Tovey MG.
TL1A: a mediator of gut inflammation.
Proc. Natl. Acad. Sci. U.S.A. 103: 8303-4, 2006.
56)  Young HA.
Unraveling the pros and cons of interferon-gamma gene regulation.
Immunity. 24: 506-7, 2006.
57)  Gao Z, Chiao P, Zhang X, Zhang X, Lazar MA, Seto E, Young HA, Ye J.
Coactivators and corepressors of NF-kappaB in IkappaB alpha gene promoter.
J Biol Chem. 280: 21091-8, 2005.
58)  Khaled AR, Bulavin DV, Kittipatarin C, Li WQ, Alvarez M, Kim K, Young HA, Fornace AJ, Durum SK.
Cytokine-driven cell cycling is mediated through Cdc25A.
J Cell Biol. 169: 755-63, 2005.
59)  Brittingham KC, Ruthel G, Panchal RG, Fuller CL, Ribot WJ, Hoover TA, Young HA, Anderson AO, Bavari S.
Dendritic cells endocytose Bacillus anthracis spores: implications for anthrax pathogenesis.
J Immunol. 174: 5545-52, 2005.
60)  Mocellin S, Marincola FM, Young HA.
Interleukin-10 and the immune response against cancer: a counterpoint.
J. Leukoc. Biol. 78: 1043-51, 2005.
61)  Ortaldo JR, Young HA.
Mouse Ly49 NK receptors: balancing activation and inhibition.
Mol Immunol. 42: 445-50, 2005.
62)  Youn HS, Lee JY, Fitzgerald KA, Young HA, Akira S, Hwang DH.
Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex.
J. Immunol. 175: 3339-46, 2005.
63)  Rodriguez-Galán MC, Bream JH, Farr A, Young HA.
Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression.
J Immunol. 174: 2796-804, 2005.
64)  Malolanarasimhan K, Lai CC, Kelley JA, Iaccarino L, Reynolds D, Young HA, Marquez VE.
Synthesis and biological study of a flavone acetic acid analogue containing an azido reporting group designed as a multifunctional binding site probe.
Bioorg Med Chem. 13: 2717-22, 2005.
65)  Lyakh LA, Sanford M, Chekol S, Young HA, Roberts AB.
TGF-beta and vitamin D3 utilize distinct pathways to suppress IL-12 production and modulate rapid differentiation of human monocytes into CD83+ dendritic cells.
J Immunol. 174: 2061-70, 2005.
66)  Ichiki H, Hoshino T, Kinoshita T, Imaoka H, Kato S, Inoue H, Nakamura H, Yodoi J, Young HA, Aizawa H.
Thioredoxin suppresses airway hyperresponsiveness and airway inflammation in asthma.
Biochem. Biophys. Res. Commun. 334: 1141-8, 2005.
67)  Krakauer T, Chen X, Howard OM, Young HA.
Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines.
Immunopharmacol Immunotoxicol. 27: 53-66, 2005.
68)  Bream JH, Hodge DL, Gonsky R, Spolski R, Leonard WJ, Krebs S, Targan S, Morinobu A, O'Shea JJ, Young HA.
A distal region in the IFN-gamma gene is a site of epigenetic remodeling and transcriptional regulation by IL-2.
J Biol Chem. 279: 41249-67, 2004.
69)  Albright JW, Bream JH, Bere EW, Young HA, Winkler-Pickett R, Ortaldo JR.
Aging of innate immunity: functional comparisons of NK/LAK cells obtained from bulk cultures of young and aged mouse spleen cells in high concentrations of interleukin-2.
Exp Gerontol. 39: 73-82, 2004.
70)  Blonder J, Rodriguez-Galan MC, Chan KC, Lucas DA, Yu LR, Conrads TP, Issaq HJ, Young HA, Veenstra TD.
Analysis of murine natural killer cell microsomal proteins using two-dimensional liquid chromatography coupled to tandem electrospray ionization mass spectrometry.
J Proteome Res. 3: 862-70, 2004.
71)  Wessells J, Baer M, Young HA, Claudio E, Brown K, Siebenlist U, Johnson PF.
BCL-3 and NF-kappaB p50 attenuate lipopolysaccharide-induced inflammatory responses in macrophages.
J Biol Chem. 279: 49995-50003, 2004.
72)  Ortaldo JR, Young HA, Winkler-Pickett RT, Bere EW, Murphy WJ, Wiltrout RH.
Dissociation of NKT stimulation, cytokine induction, and NK activation in vivo by the use of distinct TCR-binding ceramides.
J Immunol. 172: 943-53, 2004.
73)  Jiang Q, Li WQ, Hofmeister RR, Young HA, Hodge DR, Keller JR, Khaled AR, Durum SK.
Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members.
Mol Cell Biol. 24: 6501-13, 2004.
74)  Gonsky R, Deem RL, Bream J, Young HA, Targan SR.
Enhancer role of STAT5 in CD2 activation of IFN-gamma gene expression.
J Immunol. 173: 6241-7, 2004.
75)  Gamero AM, Young HA, Wiltrout RH.
Inactivation of Stat3 in tumor cells: releasing a brake on immune responses against cancer?.
Cancer Cell. 5: 111-2, 2004.
76)  Young HA, Hodge DL.
Interferon-γ. Encyclopedia of Hormones. Drs. Helen L. Henry and Anthony W. Norman (Ed).
Academic Press, San Diego, CA. in press, 2004.
77)  Srisodsai A, Kurotani R, Chiba Y, Sheikh F, Young HA, Donnelly RP, Kimura S.
Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1.
J Biol Chem. 279: 54358-68, 2004.
78)  Moayeri M, Martinez NW, Wiggins J, Young HA, Leppla SH.
Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity.
Infect Immun. 72: 4439-47, 2004.
79)  Zhang X, Rodriguez-Galán MC, Subleski JJ, Ortaldo JR, Hodge DL, Wang JM, Shimozato O, Reynolds DA, Young HA.
Peroxisome proliferator-activated receptor-gamma and its ligands attenuate biologic functions of human natural killer cells.
Blood. 104: 3276-84, 2004.
80)  Blonder J, Rodriguez-Galan MC, Lucas DA, Young HA, Issaq HJ, Veenstra TD, Conrads TP.
Proteomic investigation of natural killer cell microsomes using gas-phase fractionation by mass spectrometry.
Biochim Biophys Acta. 1698: 87-95, 2004.
81)  Warfield KL, Perkins JG, Swenson DL, Deal EM, Bosio CM, Aman MJ, Yokoyama WM, Young HA, Bavari S.
Role of natural killer cells in innate protection against lethal ebola virus infection.
J Exp Med. 200: 169-79, 2004.
82)  Megjugorac NJ, Young HA, Amrute SB, Olshalsky SL, Fitzgerald-Bocarsly P.
Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells.
J Leukoc Biol. 75: 504-14, 2004.
83)  Salcedo R, Zhang X, Young HA, Michael N, Wasserman K, Ma WH, Martins-Green M, Murphy WJ, Oppenheim JJ.
Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells.
Blood. 102: 1966-77, 2003.
84)  Moayeri M, Haines D, Young HA, Leppla SH.
Bacillus anthracis lethal toxin induces TNF-alpha-independent hypoxia-mediated toxicity in mice.
J Clin Invest. 112: 670-82, 2003.
85)  Gonsky R, Deem RL, Young HA, Targan SR.
CD2 mediates activation of the IFN-gamma intronic STAT binding region in mucosal T cells.
Eur J Immunol. 33: 1152-62, 2003.
86)  Kim K, Khaled AR, Reynolds D, Young HA, Lee CK, Durum SK.
Characterization of an interleukin-7-dependent thymic cell line derived from a p53(-/-) mouse.
J Immunol Methods. 274: 177-84, 2003.
87)  Muegge K, Young H, Ruscetti F, Mikovits J.
Epigenetic control during lymphoid development and immune responses: aberrant regulation, viruses, and cancer.
Ann N Y Acad Sci. 983: 55-70, 2003.
88)  Ortaldo JR, Young HA.
Expression of IFN-gamma upon triggering of activating Ly49D NK receptors in vitro and in vivo: costimulation with IL-12 or IL-18 overrides inhibitory receptors.
J Immunol. 170: 1763-9, 2003.
89)  Chevillard C, Moukoko CE, Elwali NE, Bream JH, Kouriba B, Argiro L, Rahoud S, Mergani A, Henri S, Gaudart J, Mohamed-Ali Q, Young HA, Dessein AJ.
IFN-gamma polymorphisms (IFN-gamma +2109 and IFN-gamma +3810) are associated with severe hepatic fibrosis in human hepatic schistosomiasis (Schistosoma mansoni).
J Immunol. 171: 5596-601, 2003.
90)  Bream JH, Curiel RE, Yu CR, Egwuagu CE, Grusby MJ, Aune TM, Young HA.
IL-4 synergistically enhances both IL-2- and IL-12-induced IFN-{gamma} expression in murine NK cells.
Blood. 102: 207-214, 2003.
91)  Geisbert TW, Young HA, Jahrling PB, Davis KJ, Kagan E, Hensley LE.
Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event.
J Infect Dis. 188: 1618-29, 2003.
92)  Geisbert TW, Hensley LE, Larsen T, Young HA, Reed DS, Geisbert JB, Scott DP, Kagan E, Jahrling PB, Davis KJ.
Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection.
Am J Pathol. 163: 2347-70, 2003.
93)  Geisbert TW, Young HA, Jahrling PB, Davis KJ, Larsen T, Kagan E, Hensley LE.
Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells.
Am J Pathol. 163: 2371-82, 2003.
94)  Geisbert TW, Young HA, Jahrling PB, Davis KJ, Larsen T, Kagan E, Hensley LE.
Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells.
Am J Pathol. 163: 2371-82, 2003.
95)  Mason LH, Willette-Brown J, Anderson SK, Alvord WG, Klabansky RL, Young HA, Ortaldo JR.
Receptor glycosylation regulates Ly-49 binding to MHC class I.
J Immunol. 171: 4235-42, 2003.
96)  Hoshino T, Nakamura H, Okamoto M, Kato S, Araya S, Nomiyama K, Oizumi K, Young HA, Aizawa H, Yodoi J.
Redox-active protein thioredoxin prevents proinflammatory cytokine- or bleomycin-induced lung injury.
Am J Respir Crit Care Med. 168: 1075-83, 2003.
97)  Krakauer T, Chen X, Howard OM, Young HA.
RNase protection assay for the study of the differential effects of therapeutic agents in suppressing staphylococcal enterotoxin B-induced cytokines in human peripheral blood mononuclear cells.
Methods Mol Biol. 214: 151-64, 2003.
98)  Saitoh S, Odom S, Gomez G, Sommers CL, Young HA, Rivera J, Samelson LE.
The Four Distal Tyrosines Are Required for LAT-dependent Signaling in Fc{varepsilon}RI-mediated Mast Cell Activation.
J Exp Med. 198: 831-843, 2003.
99)  Geisbert TW, Hensley LE, Jahrling PB, Larsen T, Geisbert JB, Paragas J, Young HA, Fredeking TM, Rote WE, Vlasuk GP.
Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys.
Lancet. 362: 1953-8, 2003.
100)  Bream JH, Ping A, Zhang X, Winkler C, Young HA.
A single nucleotide polymorphism in the proximal IFN-gamma promoter alters control of gene transcription.
Genes Immun. 3: 165-9, 2002.
101)  Lyakh LA, Koski GK, Young HA, Spence SE, Cohen PA, Rice NR.
Adenovirus type 5 vectors induce dendritic cell differentiation in human CD14(+) monocytes cultured under serum-free conditions.
Blood. 99: 600-8, 2002.
102)  Khaled AR, Li WQ, Huang J, Fry TJ, Khaled AS, Mackall CL, Muegge K, Young HA, Durum SK.
Bax deficiency partially corrects interleukin-7 receptor alpha deficiency.
Immunity. 17: 561-73, 2002.
103)  Bodor J, Bodorova J, Bare C, Hodge DL, Young HA, Gress RE.
Differential inducibility of the transcriptional repressor ICER and its role in modulation of Fas ligand expression in T and NK lymphocytes.
Eur J Immunol. 32: 203-12, 2002.
104)  Zhu J, Guo L, Min B, Watson CJ, Hu-Li J, Young HA, Tsichlis PN, Paul WE.
Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation.
Immunity. 16: 733-44, 2002.
105)  Hodge DL, Schill WB, Wang JM, Blanca I, Reynolds DA, Ortaldo JR, Young HA.
IL-2 and IL-12 alter NK cell responsiveness to IFN-gamma-inducible protein 10 by down-regulating CXCR3 expression.
J Immunol. 168: 6090-6098, 2002.
106)  Rajnavolgyi E, Benbernou N, Rethi B, Reynolds D, Young HA, Magocsi M, Muegge K, Durum SK.
IL-7 withdrawal induces a stress pathway activating p38 and Jun N-terminal kinases.
Cell Signal. 14: 761-9, 2002.
107)  Shimozato O, Ortaldo JR, Komschlies KL, Young HA.
Impaired NK cell development in an IFN-gamma transgenic mouse: aberrantly expressed IFN-gamma enhances hematopoietic stem cell apoptosis and affects NK cell differentiation.
J Immunol. 168: 1746-1752, 2002.
108)  Okamoto M, Kato S, Oizumi K, Kinoshita M, Inoue Y, Hoshino K, Akira S, McKenzie AN, Young HA, Hoshino T.
Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia.
Blood. 99: 1289-98, 2002.
109)  Zhang X, Young HA.
PPAR and immune system--what do we know.
Int Immunopharmacol. 2: 1029-44, 2002.
110)  Hensley LE, Young HA, Jahrling PB, Geisbert TW.
Proinflammatory response during Ebola virus infection of primate models: possible involvement of the tumor necrosis factor receptor superfamily.
Immunol Lett. 80: 169-79, 2002.
111)  Kershaw MH, Wang G, Westwood JA, Pachynski RK, Tiffany HL, Marincola FM, Wang E, Young HA, Murphy PM, Hwu P.
Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2.
Hum Gene Ther. 13: 1971-80, 2002.
112)  Samten B, Ghosh P, Yi AK, Weis SE, Lakey DL, Gonsky R, Pendurthi U, Wizel B, Zhang Y, Zhang M, Gong J, Fernandez M, Safi H, Vankayalapati R, Young HA, Barnes PF.
Reduced expression of nuclear cyclic adenosine 5'-monophosphate response element-binding proteins and IFN-gamma promoter function in disease due to an intracellular pathogen.
J Immunol. 168: 3520-6, 2002.
113)  Ortaldo JR, Bere EW, Hodge D, Young HA.
Activating Ly-49 NK receptors: central role in cytokine and chemokine production.
J Immunol. 166: 4994-4999, 2001.
114)  Martínez A, Hodge DL, Garayoa M, Young HA, Cuttitta F.
Alternative splicing of the proadrenomedullin gene results in differential expression of gene products.
J Mol Endocrinol. 27: 31-41, 2001.
115)  Wigginton JM, Park JW, Gruys ME, Young HA, Jorcyk CL, Back TC, Brunda MJ, Strieter RM, Ward J, Green JE, Wiltrout RH.
Complete regression of established spontaneous mammary carcinoma and the therapeutic prevention of genetically programmed neoplastic transition by IL-12/pulse IL-2: induction of local T cell infiltration, Fas/Fas ligand gene expression, and mammary epithelial apoptosis.
J Immunol. 166: 1156-68, 2001.
116)  Hoshino T, Kawase Y, Okamoto M, Yokota K, Yoshino K, Yamamura K, Miyazaki J, Young HA, Oizumi K.
Cutting edge: IL-18-transgenic mice: in vivo evidence of a broad role for IL-18 in modulating immune function.
J Immunol. 166: 7014-8, 2001.
117)  Zhang X, Wang JM, Gong WH, Mukaida N, Young HA.
Differential regulation of chemokine gene expression by 15-deoxy-delta 12,14 prostaglandin J2.
J Immunol. 166: 7104-7111, 2001.
118)  Salcedo R, Young HA, Ponce ML, Ward JM, Kleinman HK, Murphy WJ, Oppenheim JJ.
Eotaxin (CCL11) induces in vivo angiogenic responses by human CCR3+ endothelial cells.
J Immunol. 166: 7571-8, 2001.
119)  Kim SH, Reznikov LL, Stuyt RJ, Selzman CH, Fantuzzi G, Hoshino T, Young HA, Dinarello CA.
Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain.
J Immunol. 166: 148-54, 2001.
120)  Lee JK, Back TC, Komschlies KL, Ruscetti FW, Young HA, Wiltrout RH.
Hematopoietic switch from lymphoid to granulocytic development in 3LL tumor-bearing mice.
In Vivo. 15: 255-63, 2001.
121)  Mazzoni A, Young HA, Spitzer JH, Visintin A, Segal DM.
Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization.
J Clin Invest. 108: 1865-73, 2001.
122)  Blanca IR, Bere EW, Young HA, Ortaldo JR.
Human B cell activation by autologous NK cells is regulated by CD40-CD40 ligand interaction: role of memory B cells and CD5+ B cells.
J Immunol. 167: 6132-9, 2001.
123)  Khaled AR, Reynolds DA, Young HA, Thompson CB, Muegge K, Durum SK.
Interleukin-3 withdrawal induces an early increase in mitochondrial membrane potential unrelated to the Bcl-2 family. Roles of intracellular pH, ADP transport, and F(0)F(1)-ATPase.
J Biol Chem. 276: 6453-62, 2001.
124)  Krakauer T, Li BQ, Young HA.
The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines.
FEBS Lett. 500: 52-5, 2001.
125)  El-Omar EM, Carrington M, Chow WH, McColl KE, Bream JH, Young HA, Herrera J, Lissowska J, Yuan CC, Rothman N, Lanyon G, Martin M, Fraumeni JF, Rabkin CS.
The role of interleukin-1 polymorphisms in the pathogenesis of gastric cancer.
Nature. 412: 99, 2001.
126)  Shin HD, Winkler C, Stephens JC, Bream J, Young H, Goedert JJ, O'Brien TR, Vlahov D, Buchbinder S, Giorgi J, Rinaldo C, Donfield S, Willoughby A, O'Brien SJ, Smith MW.
Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10.
Proc Natl Acad Sci U S A. 97: 14467-72, 2000.
127)  Lapointe R, Toso JF, Butts C, Young HA, Hwu P.
Human dendritic cells require multiple activation signals for the efficient generation of tumor antigen-specific T lymphocytes.
Eur J Immunol. 30: 3291-8, 2000.
128)  Salcedo R, Ponce ML, Young HA, Wasserman K, Ward JM, Kleinman HK, Oppenheim JJ, Murphy WJ.
Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression.
Blood. 96: 34-40, 2000.
129)  Lee JK, Sayers TJ, Brooks AD, Back TC, Young HA, Komschlies KL, Wigginton JM, Wiltrout RH.
IFN-gamma-dependent delay of in vivo tumor progression by Fas overexpression on murine renal cancer cells.
J Immunol. 164: 231-9, 2000.
130)  Apolloni E, Bronte V, Mazzoni A, Serafini P, Cabrelle A, Segal DM, Young HA, Zanovello P.
Immortalized myeloid suppressor cells trigger apoptosis in antigen-activated T lymphocytes.
J Immunol. 165: 6723-30, 2000.
131)  Hoshino T, Yagita H, Ortaldo JR, Wiltrout RH, Young HA.
In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD4+ T cells.
Eur J Immunol. 30: 1998-2006, 2000.
132)  Hwu P, Du MX, Lapointe R, Do M, Taylor MW, Young HA.
Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation.
J Immunol. 164: 3596-9, 2000.
133)  El-Omar EM, Carrington M, Chow WH, McColl KE, Bream JH, Young HA, Herrera J, Lissowska J, Yuan CC, Rothman N, Lanyon G, Martin M, Fraumeni JF, Rabkin CS.
Interleukin-1 polymorphisms associated with increased risk of gastric cancer.
Nature. 404: 398-402, 2000.
134)  Gonsky R, Deem RL, Bream JH, Lee DH, Young HA, Targan SR.
Mucosa-specific targets for regulation of IFN-gamma expression: lamina propria T cells use different cis-elements than peripheral blood T cells to regulate transactivation of IFN-gamma expression.
J Immunol. 164: 1399-407, 2000.
135)  Taylor GA, Collazo CM, Yap GS, Nguyen K, Gregorio TA, Taylor LS, Eagleson B, Secrest L, Southon EA, Reid SW, Tessarollo L, Bray M, McVicar DW, Komschlies KL, Young HA, Biron CA, Sher A, Vande Woude GF.
Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP.
Proc Natl Acad Sci U S A. 97: 751-5, 2000.
136)  Bream JH, Carrington M, O'Toole S, Dean M, Gerrard B, Shin HD, Kosack D, Modi W, Young HA, Smith MW.
Polymorphisms of the human IFNG gene noncoding regions.
Immunogenetics. 51: 50-8, 2000.
137)  Bosco MC, Rapisarda A, Massazza S, Melillo G, Young H, Varesio L.
The tryptophan catabolite picolinic acid selectively induces the chemokines macrophage inflammatory protein-1 alpha and -1 beta in macrophages.
J Immunol. 164: 3283-91, 2000.
138)  Bream JH, Young HA, Rice N, Martin MP, Smith MW, Carrington M, O'Brien SJ.
CCR5 promoter alleles and specific DNA binding factors.
Science. 284: 223, 1999.
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