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Our Science – Young Website

Howard A. Young, Ph.D.

Selected Publications

1)  Hodge DL, Berthet C, Coppola V, Kastenmüller W, Buschman MD, Schaughency PM, Shirota H, Scarzello AJ, Subleski JJ, Anver MR, Ortaldo JR, Lin F, Reynolds DA, Sanford ME, Kaldis P, Tessarollo L, Klinman DM, Young HA.
IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice.
J. Autoimmun. [Epub ahead of print], 2014.
[Journal]
2)  McFarland AP, Savan R, Wagage S, Addison A, Ramakrishnan K, Karwan M, Duong T, Young HA.
Localized delivery of interferon-beta by Lactobacillus exacerbates experimental colitis.
PLoS ONE. 6: e16967, 2011.
[Journal]
3)  Savan R, McFarland AP, Reynolds DA, Feigenbaum L, Ramakrishnan K, Karwan M, Shirota H, Klinman DM, Dunleavy K, Pittaluga S, Anderson SK, Donnelly RP, Wilson WH, Young HA.
A novel role for IL-22R1 as a driver of inflammation.
Blood. 117: 575-84, 2011.
[Journal]
4)  Ortaldo JR, Winkler-Pickett R, Wigginton J, Horner M, Bere EW, Mason AT, Bhat N, Cherry J, Sanford M, Hodge DL, Young HA.
Regulation of ITAM-positive receptors: role of IL-12 and IL-18.
Blood. 107: 1468-75, 2006.
[Journal]
5)  Hodge DL, Martinez A, Julias JG, Taylor LS, Young HA.
Regulation of nuclear gamma interferon gene expression by interleukin 12 (IL-12) and IL-2 represents a novel form of posttranscriptional control.
Mol Cell Biol. 22: 1742-1753, 2002.
[Journal]
6)  Barrios B, Baez NS, Reynolds D, Iribarren P, Cejas H, Young HA, Rodriguez-Galan MC.
Abrogation of TNFa Production during Cancer Immunotherapy Is Crucial for Suppressing Side Effects Due to the Systemic Expression of IL-12.
PLoS ONE. 9: e90116, 2014.
[Journal]
7)  Lee YJ, Zhang X, Vazquez E, Shivasabesan G, Young HA, Murphy A, Wang H, Suffredini AF, Siebenlist U, Kottilil S.
Impaired HCV clearance in HIV/HCV coinfected subjects treated with PegIFN and RBV due to interference of IFN signaling by IFNaR2a.
J. Interferon Cytokine Res. 34: 28-34, 2014.
[Journal]
8)  Heinecke JL, Ridnour LA, Cheng RY, Switzer CH, Lizardo MM, Khanna C, Glynn SA, Hussain SP, Young HA, Ambs S, Wink DA.
Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression.
Proc. Natl. Acad. Sci. U.S.A. 111: 6323-8, 2014.
[Journal]
9)  Smith LM, Hensley LE, Geisbert TW, Johnson J, Stossel A, Honko A, Yen JY, Geisbert J, Paragas J, Fritz E, Olinger G, Young HA, Rubins KH, Karp CL.
Interferon-ß Therapy Prolongs Survival in Rhesus Macaque Models of Ebola and Marburg Hemorrhagic Fever.
J. Infect. Dis. 208: 310-8, 2013.
[Journal]
10)  Xiao Z, Jiang Q, Willette-Brown J, Xi S, Zhu F, Burkett S, Back T, Song NY, Datla M, Sun Z, Goldszmid R, Lin F, Cohoon T, Pike K, Wu X, Schrump DS, Wong KK, Young HA, Trinchieri G, Wiltrout RH, Hu Y.
The Pivotal Role of IKKa in the Development of Spontaneous Lung Squamous Cell Carcinomas.
Cancer Cell. 23: 527-40, 2013.
[Journal]
Click Here to View Expanded Bibliography.

This page was last updated on 6/17/2014.