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Our Science – Strathern Website

Jeffrey N. Strathern, Ph.D.

Selected Publications

1)  Imashimizu M, Kireeva ML, Lubkowska L, Gotte D, Parks AR, Strathern JN, Kashlev M.
Intrinsic translocation barrier as an initial step in pausing by RNA polymerase II.
J. Mol. Biol. 425: 697-712, 2013.
[Journal]
2)  Zhou YN, Lubkowska L, Hui M, Court C, Chen S, Court DL, Strathern J, Jin DJ, Kashlev M.
Isolation and characterization of RNA polymerase rpoB mutations that alter transcription slippage during elongation in Escherichia coli.
J. Biol. Chem. 288: 2700-10, 2013.
[Journal]
3)  Strathern J, Malagon F, Irvin J, Gotte D, Shafer B, Kireeva M, Lubkowska L, Jin DJ, Kashlev M.
The fidelity of transcription: RPB1 (RPO21) mutations that increase transcriptional slippage in S. cerevisiae.
J. Biol. Chem. 288: 2689-99, 2013.
[Journal]
4)  Strathern JN, Jin DJ, Court DL, Kashlev M.
Isolation and characterization of transcription fidelity mutants.
Biochim Biophys Acta B. 1819: 694-9, 2012.
[Journal]
5)  Walmacq C, Cheung AC, Kireeva ML, Lubkowska L, Ye C, Gotte D, Strathern JN, Carell T, Cramer P, Kashlev M.
Mechanism of translesion transcription by RNA polymerase II and its role in cellular resistance to DNA damage.
Mol. Cell. 46: 18-29, 2012.
[Journal]
6)  Walmacq C, Kireeva ML, Irvin J, Nedialkov Y, Lubkowska L, Malagon F, Strathern JN, Kashlev M.
Rpb9 Subunit Controls Transcription Fidelity by Delaying NTP Sequestration in RNA Polymerase II.
J. Biol. Chem. 284: 19601-12, 2009.
[Journal]
7)  Ambrose Z, Herman BD, Sheen C, Zelina S, Moore KL, Tachedjian G, Nissley DV, Sluis-Cremer N.
The human immunodeficiency virus type 1 (HIV-1) nonnucleoside reverse transcriptase inhibitor resistance mutation I132M confers hypersensitivity to nucleoside analogs.
J. Virol. 83: 3826-33, 2009.
[Journal]
8)  Santoyo G, Strathern JN.
Non-homologous end joining is important for repair of Cr(VI)-induced DNA damage in Saccharomyces cerevisiae.
Microbiol. Res. 163: 113-9, 2008.
[Journal]
9)  Kireeva ML, Nedialkov YA, Cremona GH, Purtov YA, Lubkowska L, Malagon F, Burton ZF, Strathern JN, Kashlev M.
Transient reversal of RNA polymerase II active site closing controls fidelity of transcription elongation.
Mol. Cell. 30: 557-66, 2008.
[Journal]
10)  Nissley DV, Radzio J, Ambrose Z, Sheen CW, Hamamouch N, Moore KL, Tachedjian G, Sluis-Cremer N.
Characterization of novel non-nucleoside reverse transcriptase (RT) inhibitor resistance mutations at residues 132 and 135 in the 51 kDa subunit of HIV-1 RT.
Biochem. J. 404: 151-7, 2007.
[Journal]
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This page was last updated on 5/1/2013.