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Carole A. Parent, Ph.D.

Selected Publications

1)  Kriebel PW, Barr VA, Parent CA.
Adenylyl cyclase localization regulates streaming during chemotaxis.
Cell. 112: 549-560, 2003.
2)  Kriebel PW, Barr VA, Rericha EC, Zhang G, Parent CA.
Collective cell migration requires vesicular trafficking for chemoattractant delivery at the trailing edge.
J. Cell Biol. 183: 949-61, 2008.
3)  Liu L, Das S, Losert W, Parent CA.
mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion.
Dev. Cell. 19: 845-57, 2010.
4)  Afonso PV, Janka-Junttila M, Lee YJ, McCann CP, Oliver CM, Aamer KA, Losert W, Cicerone MT, Parent CA.
LTB(4) is a signal-relay molecule during neutrophil chemotaxis.
Dev. Cell. 22: 1079-91, 2012.
5)  Weiger MC, Vedham V, Stuelten CH, Shou K, Herrera M, Sato M, Losert W, Parent CA.
Real-time motion analysis reveals cell directionality as an indicator of breast cancer progression.
PLoS ONE. 8: e58859, 2013.
6)  Moissoglu K, Majumdar R, Parent CA.
Cell migration: sinking in a gradient.
Curr. Biol. 24: R23-5, 2014.
7)  McCann CP, Rericha EC, Wang C, Losert W, Parent CA.
Dictyostelium cells migrate similarly on surfaces of varying chemical composition.
PLoS ONE. 9: e87981, 2014.
8)  Majumdar R, Sixt M, Parent CA.
New paradigms in the establishment and maintenance of gradients during directed cell migration.
Curr. Opin. Cell Biol. 30C: 33-40, 2014.
9)  Liu L, Gritz D, Parent CA.
PKCßII Acts Downstream of Chemoattractant Receptors and mTORC2 to Regulate cAMP Production and Myosin II Activity in Neutrophils.
Mol. Biol. Cell. 25: 1446-57, 2014.
10)  McCann CP, Parent C.
Lennarz W, Lane M, eds.
Eukaryotic chemotaxis. In: The Encyclopedia of Biological Chemistry. Volume 2.
London, UK: Academic Press, Elsevier; 2013. p. 236-240 [Book Chapter]
11)  Afonso PV, Parent CA.
[Leukotriene B(4): a lipid at the heart of inflammation].
Med Sci (Paris). 29: 1083-5, 2013.
12)  Afonso PV, McCann CP, Kapnick SM, Parent CA.
Discoidin domain receptor 2 regulates neutrophil chemotaxis in 3D collagen matrices.
Blood. 121: 1644-50, 2013.
13)  Lämmermann T, Afonso PV, Angermann BR, Wang JM, Kastenmüller W, Parent CA, Germain RN.
Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo.
Nature. 371: 371-375, 2013.
14)  Brzostowski JA, Sawai S, Rozov O, Liao X, Imoto D, Parent CA, Kimmel AR.
Phosphorylation of chemoattractant receptors regulates chemotaxis, actin re-organization, and signal-relay.
J. Cell. Sci. 126: 4614-26, 2013.
15)  Parent CA, Weiner OD.
The symphony of cell movement: how cells orchestrate diverse signals and forces to control migration.
Curr. Opin. Cell Biol. 25: 523-5, 2013.
16)  Yan J, Mihaylov V, Xu X, Brzostowski JA, Li H, Liu L, Veenstra TD, Parent CA, Jin T.
A Gbetagamma Effector, ElmoE, Transduces GPCR Signaling to the Actin Network during Chemotaxis.
Dev. Cell. 22: 92-103, 2012.
17)  Driscoll MK, McCann C, Kopace R, Homan T, Fourkas JT, Parent C, Losert W.
Cell shape dynamics: from waves to migration.
PLoS Comput. Biol. 8: e1002392, 2012.
18)  Afonso PV, Parent CA.
Neutrophils under tension.
Dev. Cell. 22: 236-8, 2012.
19)  Weiger MC, Parent CA.
Phosphoinositides in chemotaxis.
Subcell. Biochem. 59: 217-54, 2012.
20)  Liu L, Aerbajinai W, Ahmed SM, Rodgers GP, Angers S, Parent CA.
Radil controls neutrophil adhesion and motility through β2-integrin activation.
Mol. Biol. Cell. 23: 4751-65, 2012.
21)  Sixt M, Parent CA.
Cells on the move in Philadelphia.
Mol. Biol. Cell. 22: 724, 2011.
22)  Zhang S, Readinger JA, DuBois W, Janka-Junttila M, Robinson R, Pruitt M, Bliskovsky V, Wu JZ, Sakakibara K, Patel J, Parent CA, Tessarollo L, Schwartzberg PL, Mock BA.
Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production.
Blood. 117: 1228-38, 2011.
23)  Das S, Rericha EC, Bagorda A, Parent CA.
Direct Biochemical Measurements of Signal Relay during Dictyostelium Development.
J. Biol. Chem. 286: 38649-58, 2011.
24)  Aerbajinai W, Liu L, Chin K, Zhu J, Parent CA, Rodgers GP.
Glia maturation factor-{gamma} mediates neutrophil chemotaxis.
J. Leukoc. Biol. 90(3): 529-38, 2011.
25)  Afonso PV, Parent CA.
PI3K and Chemotaxis: A Priming Issue?.
Sci Signal. 4: pe22, 2011.
26)  Liu L, Parent CA.
Review series: TOR kinase complexes and cell migration.
J. Cell Biol. 194: 815-24, 2011.
27)  Chen PW, Randazzo PA, Parent CA.
ACAP-A/B are ArfGAP homologs in dictyostelium involved in sporulation but not in chemotaxis.
PLoS ONE. 5: e8624, 2010.
28)  McCann CP, Kriebel PW, Parent CA, Losert W.
Cell speed, persistence and information transmission during signal relay and collective migration.
J. Cell. Sci. 123: 1724-31, 2010.
29)  Shu S, Liu X, Kriebel PW, Hong M, Daniels MP, Parent CA, Korn ED.
Expression of actin Tyr53Ala in Dictyostelium disrupts the cytoskeleton and inhibits intracellular and intercellular chemotactic-signaling.
J. Biol. Chem. 285: 27713-25, 2010.
30)  Cai H, Das S, Kamimura Y, Long Y, Parent CA, Devreotes PN.
Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis.
J. Cell Biol. 190: 233-45, 2010.
31)  Kriebel PW, Parent CA.
Group migration and signal relay in Dictyostelium.
Methods Mol. Biol. 571: 111-24, 2009.
32)  Bagorda A, Das S, Rericha EC, Chen D, Davidson J, Parent CA.
Real-time measurements of cAMP production in live Dictyostelium cells.
J. Cell. Sci. 122: 3907-14, 2009.
33)  Garcia GL, Rericha EC, Heger CD, Goldsmith PK, Parent CA.
The Group Migration of Dictyostelium Cells Is Regulated by Extracellular Chemoattractant Degradation.
Mol. Biol. Cell. 20: 3295-3304, 2009.
34)  Bagorda A, Parent CA.
Eukaryotic chemotaxis at a glance.
J. Cell. Sci. 121: 2621-4, 2008.
35)  Garcia GL, Parent CA.
Signal relay during chemotaxis.
J. Microsc. 231: 529-34, 2008.
36)  Rericha EC, Parent CA.
Steering in quadruplet: the complex signaling pathways directing chemotaxis.
Sci. Signal. 1: pe26, 2008.
37)  Mahadeo DC, Janka-Junttila M, Smoot RL, Roselova P, Parent CA.
A chemoattractant-mediated Gi-coupled pathway activates adenylyl cyclase in human neutrophils.
Mol. Biol. Cell. 18: 512-22, 2007.
38)  Comer FI, Parent CA.
Phosphoinositides specify polarity during epithelial organ development.
Cell. 128: 239-40, 2007.
39)  Khosla M, Kriebel P, Parent CA, Spiegelman GB, Weeks G.
A secondary disruption of the dmpA gene encoding a large membrane protein allows aggregation defective Dictyostelium rasC- cells to form multicellular structures.
Dev. Biol. 292: 68-78, 2006.
40)  Bagorda A, Mihaylov VA, Parent CA.
Chemotaxis: moving forward and holding on to the past.
Thromb. Haemost. 95: 12-21, 2006.
41)  Comer FI, Parent CA.
Phosphoinositide 3-kinase activity controls the chemoattractant-mediated activation and adaptation of adenylyl cyclase.
Mol. Biol. Cell. 17: 357-66, 2006.
42)  Shu S, Mahadeo DC, Liu X, Liu W, Parent CA, Korn ED.
S-adenosylhomocysteine hydrolase is localized at the front of chemotaxing cells, suggesting a role for transmethylation during migration.
Proc. Natl. Acad. Sci. U.S.A. 103: 19788-93, 2006.
43)  Mahadeo DC, Parent CA.
Signal relay during the life cycle of dictyostelium.
Curr. Top. Dev. Biol. 73: 115-40, 2006.
44)  Shrimali RK, Lobanov AV, Xu XM, Rao M, Carlson BA, Mahadeo DC, Parent CA, Gladyshev VN, Hatfield DL.
Selenocysteine tRNA identification in the model organisms Dictyostelium discoideum and Tetrahymena thermophila.
Biochem Biophys Res Commun. 329: 147-51, 2005.
45)  Comer FI, Lippincott CK, Masbad JJ, Parent CA.
The PI3K-mediated activation of CRAC independently regulates adenylyl cyclase activation and chemotaxis.
Curr Biol. 15: 134-9, 2005.
46)  Lee S, Comer FI, Sasaki A, McLeod IX, Duong Y, Okumura K, Yates JR, Parent CA, Firtel RA.
TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium.
Mol. Biol. Cell. 16: 4572-83, 2005.
47)  Brzostowski JA, Parent CA, Kimmel AR.
A G alpha-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement.
Genes Dev. 18: 805-15, 2004.
48)  Kriebel PW, Parent CA.
Adenylyl cyclase expression and regulation during the differentiation of Dictyostelium discoideum.
IUBMB Life. 56: 541-6, 2004.
49)  Parent CA.
Making all the right moves: chemotaxis in neutrophils and Dictyostelium.
Curr Opin Cell Biol. 16: 4-13, 2004.
50)  Kimmel AR, Parent CA, Gough NR.
Teaching resources. Spatial and temporal dynamics of signaling components involved in the control of chemotaxis in Dictyostelium discoideum.
Sci STKE. 2004: tr3, 2004.
51)  Huang YE, Iijima M, Parent CA, Funamoto S, Firtel RA, Devreotes P.
Receptor-mediated regulation of PI3Ks confines PI (3,4,5)P3 to the leading edge of chemotaxis cells.
Mol. Biol. Cell. 14: 1913-1922, 2003.
52)  Kimmel AR, Parent CA.
The signal to move: D. discoideum go orienteering.
Science. 300: 1525-1527, 2003.
53)  Bankir L, Ahloulay M, Devreotes PN, Parent CA.
Extracellular cAMP inhibits proximal sodium reabsorption: are plasma membrane cAMP receptors involved?.
Am. J. Physiol. 282: F376-F392, 2002.
54)  Comer FI, Parent CA.
PI3 kinases and PTEN: How opposites chemoattact.
Cell. 109: 541-544, 2002.
55)  Parent CA, Borleis J, Devreotes PN.
Regulation of adenylyl cyclases by a region outside the minimally functional cytoplasmic domains.
J. Biol. Chem. 277: 1354-1360, 2002.
56)  Shu S, Liu X, Parent CA, Uyeda TQ, Korn ED.
Tail chimeras of Dictyostelium myosin II support cytokinesis and other myosin II activities but not full development.
J. Cell. Sci. 115: 4237-4249, 2002.
57)  Dormann D, Weijer G, Parent CA, Devreotes PN, Weijer CJ.
Visualizing cell-cell signaling during morphogenesis.
Curr. Biol. 12: 1178-1188, 2002.
58)  Parent CA.
Dictyostelium Cell Dynamics.
Curr. Protoc. Cell Biol. Chapter 12: Unit 12.5, 2001.
59)  Weiner OD, Servant G, Parent CA, Devreotes PN, Bourne HR.
Cell polarity in response to chemoattractants, in Cell polarity (Drubin, D.G., ed).
Frontiers in Molecular Biology (Hames, B.D. and Glover, D.M. eds.). Oxford University Press: 201-239, 2000.
60)  Jin T, Zhang N, Long Y, Parent CA, Devreotes PN.
Localization of the G protein betagamma complex in living cells during chemotaxis.
Science. 287: 1034-1036, 2000.
61)  Parent CA, Devreotes PN.
A cell’s sense of direction.
Science. 284: 765-770, 1999.
62)  Lee S, Parent CA, Insall R, Firtel RA.
A novel Ras interacting protein required for chemotaxis and cAMP signal relay in Dictyostelium.
Mol. Biol. Cell. 10: 2829-2845, 1999.
63)  Noegel AA, Rivero F, Albrecht R, Janssen KP, Köhler J, Parent CA, Schleicher M.
Assessing the role of ASP56/CAP homologue of Dictyostelium discoideum and the requirements for subcellular localization.
J. Cell Sci. 112: 3195-3203, 1999.
64)  Parent CA, Blacklock BJ, Froehlich WM, Murphy DB, Devreotes PN.
G protein signaling events are activated at the leading edge of chemotactic cells.
Cell. 95: 81-91, 1998.
65)  Vithalani KK, Parent CA, Thorn EM, Penn M, Larochelle DA, Devreotes PN, De Lozanne A.
Identification of Darlin, a Dictyostelium protein with armadillo-like repeats that binds to small GTPases and is important for the proper aggregation of developing cells.
Mol. Biol. Cell. 8: 3095-3106, 1998.
66)  Mann SK, Brown JM, Briscoe C, Parent C, Pitt G, Devreotes PN, Firtel RA.
Role of cAMP-dependent protein kinase in controlling aggregation and post-aggregative development in Dictyostelium.
Dev. Biol. 183: 208-211, 1997.
67)  Ma H, Gamper M, Parent C, Firtel RA.
The Dictyostelium MAP kinase kinase MEK1 regulates chemotaxis and is essential for chemoattractant-mediated activation of guanylyl cyclase.
EMBO J. 16: 4317-4332, 1997.
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This page was last updated on 7/3/2014.