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Our Science – Oppenheim Website

Joost J. Oppenheim, M.D.

Selected Publications

1)  Tewary P, dela Rosa G, Sharma N, Rodriguez LG, Tarasov SG, Howard OZ, Shirota H, Steinhagen F, Klinman DM, Yang D, Oppenheim JJ.
Beta Defensin 2 and 3 Promote the uptake of self or CpG DNA, Enhance IFN-alpha Production by Human Plasmacytoid Dendritic Cells and Promote Inflammation.
J. Immunol. 2013.
In Press. [Journal]
2)  Yang D, Wei F, Tewary P, Zack Howard OM, Oppenheim JJ.
Alarmin-induced cell migration.
Eur. J. Immunol. 2013.
3)  Stagliano KE, Oppenheim JJ.
DEXterity of tolerogenic APCs.
Eur. J. Immunol. 43: 38-41, 2013.
4)  Yoshimura T, Howard OM, Ito T, Kuwabara M, Matsukawa A, Chen K, Liu Y, Liu M, Oppenheim JJ, Wang JM.
Monocyte Chemoattractant Protein-1/CCL2 Produced by Stromal Cells Promotes Lung Metastasis of 4T1 Murine Breast Cancer Cells.
PLoS ONE. 8: e58791, 2013.
5)  Chen X, Wu X, Zhou Q, Howard OM, Netea MG, Oppenheim JJ.
TNFR2 Is Critical for the Stabilization of the CD4+Foxp3+ Regulatory T Cell Phenotype in the Inflammatory Environment.
J. Immunol. 190: 1076-84, 2013.
6)  Chan JK, Roth J, Oppenheim JJ, Tracey KJ, Vogl T, Feldmann M, Horwood N, Nanchahal J.
Alarmins: awaiting a clinical response.
J. Clin. Invest. 122: 2711-9, 2012.
7)  Yang D, Postnikov YV, Li Y, Tewary P, de la Rosa G, Wei F, Klinman D, Gioannini T, Weiss JP, Furusawa T, Bustin M, Oppenheim JJ.
High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.
J. Exp. Med. 209: 157-71, 2012.
8)  Yoshimura T, Oppenheim JJ.
Chemokine-like receptor 1 (CMKLR1) and chemokine (C-C motif) receptor-like 2 (CCRL2); two multifunctional receptors with unusual properties.
Exp. Cell Res. 317: 674-84, 2011.
9)  Chen X, Oppenheim JJ.
Comment on.
J. Immunol. 187: 1527; author reply 1527-8, 2011.
10)  Chen X, Oppenheim JJ.
Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity.
FEBS Lett. 585: 3611-8, 2011.
11)  Buzas K, Oppenheim JJ, Zack Howard OM.
Myeloid cells migrate in response to IL-24.
Cytokine. 55: 429-34, 2011.
12)  Chertov O, Zhang N, Chen X, Oppenheim JJ, Lubkowski J, McGrath C, Sowder RC, Crise BJ, Malyguine A, Kutzler MA, Steele AD, Henderson EE, Rogers TJ.
Novel peptides based on HIV-1 gp120 sequence with homology to chemokines inhibit HIV infection in cell culture.
PLoS ONE. 6: e14474, 2011.
13)  Qi J, Buzas K, Fan H, Cohen JI, Wang K, Mont E, Klinman D, Oppenheim JJ, Howard OM.
Painful pathways induced by TLR stimulation of dorsal root ganglion neurons.
J. Immunol. 186: 6417-26, 2011.
14)  Song C, Rahim RT, Davey PC, Bednar F, Bardi G, Zhang L, Zhang N, Oppenheim JJ, Rogers TJ.
Protein kinase Czeta mediates micro-opioid receptor-induced cross-desensitization of chemokine receptor CCR5.
J. Biol. Chem. 286: 20354-65, 2011.
15)  Chen X, Oppenheim JJ.
Resolving the identity myth: key markers of functional CD4+FoxP3+ regulatory T cells.
Int. Immunopharmacol. 11: 1489-96, 2011.
16)  Tarasov SG, Gaponenko V, Howard OM, Chen Y, Oppenheim JJ, Dyba MA, Subramaniam S, Lee Y, Michejda C, Tarasova NI.
Structural plasticity of a transmembrane peptide allows self-assembly into biologically active nanoparticles.
Proc. Natl. Acad. Sci. U.S.A. 108: 9798-803, 2011.
17)  Chen X, Oppenheim JJ.
The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4(+) FoxP3(+) regulatory T cells.
Immunology. 133: 426-33, 2011.
18)  Hamano R, Huang J, Yoshimura T, Oppenheim JJ, Chen X.
TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4-1BB and OX40.
Eur. J. Immunol. 41: 2010-20, 2011.
19)  Chen X, Oppenheim J.
Theofilopoulos A, Kollias G, eds.
Crrent Directions in Autoimmunity. Volume 11.
Basel: Karger Publisher; 2010. [Book]
20)  Yang D, Zhao Y, Guo H, Li Y, Tewary P, Xing G, Hou W, Oppenheim JJ, Zhang N.
[Gd@C(82)(OH)(22)](n) nanoparticles induce dendritic cell maturation and activate Th1 immune responses.
ACS Nano. 4: 1178-86, 2010.
21)  Chen X, Subleski JJ, Hamano R, Howard OM, Wiltrout RH, Oppenheim JJ.
Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood.
Eur. J. Immunol. 40: 1099-106, 2010.
22)  Chen X, Hamano R, Subleski JJ, Hurwitz AA, Howard OM, Oppenheim JJ.
Expression of costimulatory TNFR2 induces resistance of CD4(+)FoxP3(-) conventional T cells to suppression by CD4(+)FoxP3(+) regulatory T Cells.
J. Immunol. 185: 174-82, 2010.
23)  Tewary P, Yang D, de la Rosa G, Li Y, Finn MW, Krensky AM, Clayberger C, Oppenheim JJ.
Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin.
Blood. 116: 3465-74, 2010.
24)  Röhrl J, Yang D, Oppenheim JJ, Hehlgans T.
Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.
J. Immunol. 184: 6688-94, 2010.
25)  Röhrl J, Yang D, Oppenheim JJ, Hehlgans T.
Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells.
J. Biol. Chem. 285: 7028-34, 2010.
26)  Chen X, Oppenheim JJ.
TNF-alpha: an activator of CD4+FoxP3+TNFR2+ regulatory T cells.
Curr. Dir. Autoimmun. 11: 119-34, 2010.
27)  Yang D, Oppenheim JJ.
Alarmins and antimicrobial immunity.
Med. Mycol. 1-8, 2009.
28)  Yang D, de la Rosa G, Tewary P, Oppenheim JJ.
Alarmins link neutrophils and dendritic cells.
Trends Immunol. 30: 531-7, 2009.
29)  Taylor K, Wolfe M, Kilanowski F, Pathania U, Reynolds N, Clarke D, Yang D, Oppenheim J, Samuel K, Howie S, Barran P, Macmillan D, Campopiano D, Dorin J.
Defr1 is allelic to Defb8 and chemoattractant for immature dendritic cells and CD4 T cells but does not act through chemokine receptor 6.
Eur J Immunol. 39: 1353-1360, 2009.
30)  Chen X, Oppenheim J.
Regulatory T cells , Th17 cells and TLRs: implication for autoimmunity and cancer (review).
Pathways. 10: 2-5, 2009.
31)  Yang D, Tewary P, de la Rosa G, Wei F, Oppenheim JJ.
The alarmin functions of high-mobility group proteins.
Biochim. Biophys. Acta. 1799: 157-63, 2009.
32)  Yoshimura T, Oppenheim JJ.
Chemerin reveals its chimeric nature.
J. Exp. Med. 205: 2187-90, 2008.
33)  Wolf R, Howard OM, Dong HF, Voscopoulos C, Boeshans K, Winston J, Divi R, Gunsior M, Goldsmith P, Ahvazi B, Chavakis T, Oppenheim JJ, Yuspa SH.
Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15.
J. Immunol. 181: 1499-506, 2008.
34)  Chen X, Subleski JJ, Kopf H, Howard OM, Männel DN, Oppenheim JJ.
Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells.
J. Immunol. 180: 6467-71, 2008.
35)  Yang D, Chen Q, Su SB, Zhang P, Kurosaka K, Caspi RR, Michalek SM, Rosenberg HF, Zhang N, Oppenheim JJ.
Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses.
J. Exp. Med. 205: 79-90, 2008.
36)  Röhrl J, Yang D, Oppenheim JJ, Hehlgans T.
Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3.
J. Biol. Chem. 283: 5414-9, 2008.
37)  de la Rosa G, Yang D, Tewary P, Varadhachary A, Oppenheim JJ.
Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses.
J. Immunol. 180: 6868-76, 2008.
38)  Oppenheim JJ.
Passing the torch.
J. Leukoc. Biol. 84: 1363, 2008.
39)  Rosenberg HF, Oppenheim JJ.
The 2007 Dolph Adams Award and the state of the Journal of Leukocyte Biology.
J. Leukoc. Biol. 83: 227-8, 2008.
40)  Oppenheim JJ, Rosenberg HF.
The 2008 Dolph Adams award and the state of the journal of leukocyte biology.
J. Leukoc. Biol. 84: 1361-2, 2008.
41)  Oppenheim JJ, Tewary P, de la Rosa G, Yang D.
Alarmins initiate host defense.
Adv. Exp. Med. Biol. 601: 185-94, 2007.
42)  Yang D, Liu ZH, Tewary P, Chen Q, de la Rosa G, Oppenheim JJ.
Defensin participation in innate and adaptive immunity.
Curr. Pharm. Des. 13: 3131-9, 2007.
43)  Yang D, Chen Q, Yang H, Tracey KJ, Bustin M, Oppenheim JJ.
High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin.
J. Leukoc. Biol. 81: 59-66, 2007.
44)  Oppenheim JJ.
IL-2: more than a T cell growth factor.
J. Immunol. 179: 1413-4, 2007.
45)  Hu PQ, Hurwitz AA, Oppenheim JJ.
Immunization with DNA topoisomerase I induces autoimmune responses but not scleroderma-like pathologies in mice.
J. Rheumatol. 34: 2243-52, 2007.
46)  Chen X, Bäumel M, Männel DN, Howard OM, Oppenheim JJ.
Interaction of TNF with TNF Receptor Type 2 Promotes Expansion and Function of Mouse CD4+CD25+ T Regulatory Cells.
J. Immunol. 179: 154-61, 2007.
47)  Chen X, Howard OM, Oppenheim JJ.
Pertussis toxin by inducing IL-6 promotes the generation of IL-17-producing CD4 cells.
J. Immunol. 178: 6123-9, 2007.
48)  Liu Y, Sun R, Wan W, Wang J, Oppenheim JJ, Chen L, Zhang N.
The involvement of lipid rafts in epidermal growth factor-induced chemotaxis of breast cancer cells.
Mol. Membr. Biol. 24: 91-101, 2007.
49)  Howard O, Oppenheim J, Wang Z, Gao P.
Badolato R, Sozzani S, eds.
Biology of Chmokines: Lymphocyte trafficking in health and disease. In: Progress in Inflammation Research.
Boston: Birkhauser Verlag AG; 2006. p. 7-38 [Book Chapter]
50)  Zhang N, Oppenheim J.
Kastin A, eds.
Neuropeptides that regulate immune responses. In: The Handbook of Biologically Active Peptides.
London: Academic Press Elsevier; 2006. p. 579-584 [Book Chapter]
51)  Zhang N, Yang D, Dong H, Chen Q, Dimitrova DI, Rogers TJ, Sitkovsky M, Oppenheim JJ.
Adenosine A2a receptors induce heterologous desensitization of chemokine receptors.
Blood. 108: 38-44, 2006.
Full Text Article. [Journal]
52)  Chen X, Yang L, Howard OM, Oppenheim JJ.
Dendritic cells as a pharmacological target of traditional Chinese medicine.
Cell. Mol. Immunol. 3: 401-10, 2006.
53)  Chen X, Oppenheim JJ, Winkler-Pickett RT, Ortaldo JR, Howard OM.
Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3(+)CD4(+)CD25(+) T regulatory cells in vivo and enhances their capacity to suppress EAE.
Eur. J. Immunol. 36: 2139-49, 2006.
54)  Gamero AM, Oppenheim JJ.
IL-1 can act as number one.
Immunity. 24: 16-7, 2006.
55)  Wang ZY, Yang D, Chen Q, Leifer CA, Segal DM, Su SB, Caspi RR, Howard ZO, Oppenheim JJ.
Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways.
Exp. Hematol. 34: 1115-24, 2006.
56)  Rosenberg HF, Oppenheim JJ.
Interview with Dr. Yoshiro Kobayashi regarding Pivotal Advance: A suppressive role of nitric oxide in MIP-2 production by macrophages upon coculturing with apoptotic cells.
J. Leukoc. Biol. 80: 742-3, 2006.
57)  Chen X, Winkler-Pickett RT, Carbonetti NH, Ortaldo JR, Oppenheim JJ, Howard OM.
Pertussis toxin as an adjuvant suppresses the number and function of CD4+CD25+ T regulatory cells.
Eur. J. Immunol. 36: 671-80, 2006.
58)  Hu PQ, Oppenheim JJ, Medsger TA, Wright TM.
T cell lines from systemic sclerosis patients and healthy controls recognize multiple epitopes on DNA topoisomerase I.
J Autoimmun. 26: 258-267, 2006.
Full Text Article. [Journal]
59)  Oppenheim J, Zhang N.
Moser B, Letts G, Neote K, eds.
Immunobiology of Chemokines. In: Chemokine Biology: Basic Research and Clinical Application. Volume I.
Basel: Birkhauser Verlag; 2005. p. 137-150 [Book Chapter]
60)  Zhang N, Inan S, Inan S, Cowan A, Sun R, Wang JM, Rogers TJ, Caterina M, Oppenheim JJ.
A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1.
Proc Natl Acad Sci U S A. 102: 4536-41, 2005.
61)  Oppenheim JJ, Yang D.
Alarmins: chemotactic activators of immune responses.
Curr. Opin. Immunol. 17: 359-65, 2005.
62)  Oppenheim JJ, Dong HF, Plotz P, Caspi RR, Dykstra M, Pierce S, Martin R, Carlos C, Finn O, Koul O, Howard OM.
Autoantigens act as tissue-specific chemoattractants.
J Leukoc Biol. 77: 854-61, 2005.
63)  Howard OM, Dong HF, Su SB, Caspi RR, Chen X, Plotz P, Oppenheim JJ.
Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate.
Blood. 105: 4207-14, 2005.
64)  Chen X, Oppenheim JJ, Howard OM.
BALB/c mice have more CD4+CD25+ T regulatory cells and show greater susceptibility to suppression of their CD4+CD25- responder T cells than C57BL/6 mice.
J Leukoc Biol. 78: 114-1221, 2005.
65)  Zhang N, Oppenheim JJ.
Crosstalk between chemokines and neuronal receptors bridges immune and nervous systems.
J. Leukoc. Biol. 78: 1210-4, 2005.
66)  Carlos CA, Dong HF, Howard OM, Oppenheim JJ, Hanisch FG, Finn OJ.
Human Tumor Antigen MUC1 Is Chemotactic for Immature Dendritic Cells and Elicits Maturation but Does Not Promote Th1 Type Immunity.
J Immunol. 175: 1628-35, 2005.
67)  Jiao X, Zhang N, Xu X, Oppenheim JJ, Jin T.
Ligand-induced partitioning of human CXCR1 chemokine receptors with lipid raft microenvironments facilitates G-protein-dependent signaling.
Mol Cell Biol. 25: 5752-62, 2005.
68)  Kurosaka K, Chen Q, Yarovinsky F, Oppenheim JJ, Yang D.
Mouse cathelin-related antimicrobial peptide chemoattracts leukocytes using formyl peptide receptor-like 1/mouse formyl peptide receptor-like 2 as the receptor and acts as an immune adjuvant.
J Immunol. 174: 6257-65, 2005.
69)  Gao P, Wange RL, Zhang N, Oppenheim JJ, Howard OM.
Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN.
Blood. 106: 2619-26, 2005.
70)  Yoshimura T, Matsushima K, Oppenheim JJ, Leonard EJ.
Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: partial characterization and separation from interleukin 1 (IL 1). 1987.
J. Immunol. 175: 5569-74, 2005.
71)  Sun R, Gao P, Chen L, Ma D, Wang J, Oppenheim JJ, Zhang N.
Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells.
Cancer Res. 65: 1433-41, 2005.
72)  Krakauer T, Chen X, Howard OM, Young HA.
Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines.
Immunopharmacol Immunotoxicol. 27: 53-66, 2005.
73)  Chen X, Murakami T, Oppenheim JJ, Howard OM.
Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic cell maturation and trafficking.
Blood. 106: 2409-16, 2005.
74)  Yang D, Oppenheim J.
Devine D, Hancock R, eds.
Multiple functions of antimicrobial peptides in host immunity. In: Mammalian Antimicrobial Peptides.
New York: Cambridge University Press; 2004. p. 39-68 [Book Chapter]
75)  Yang D, Oppenheim JJ.
Antimicrobial proteins act as alarmins in joint immune defenses.
Arthritis Rheum. 50: 3401-3, 2004.
76)  Chen X, Oppenheim JJ, Howard OM.
Chemokines and chemokine receptors as novel therapeutic targets in rheumatoid arthritis (RA): Inhibitory effects of traditional Chinese medicinal components.
Cell. Molec. Immunol. 5: 336-342, 2004.
77)  Chen B, Blair DG, Plisov S, Vasiliev G, Perantoni AO, Chen Q, Athanasiou M, Wu JY, Oppenheim JJ, Yang D.
Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis.
J Immunol. 173: 5914-7, 2004.
78)  Chen X, Murakami T, Oppenheim JJ, Howard OM.
Differential response of murine CD4+CD25+ and CD4+CD25- T cells to dexamethasone-induced cell death.
Eur J Immunol. 34: 859-69, 2004.
79)  Chung IY, Dong HF, Zhang X, Hassanein NM, Howard OM, Oppenheim JJ, Chen X.
Effects of IL-7 and dexamethasone: Induction of CD25, the high affinity IL-2 receptor, on human CD4(+) cells.
Cell Immunol. 232: 57-63, 2004.
80)  Howard OM, Turpin JA, Goldman R, Modi WS.
Functional redundancy of the human CCL4 and CCL4L1 chemokine genes.
Biochem Biophys Res Commun. 320: 927-31, 2004.
81)  Yang D, Chen Q, Rosenberg HF, Rybak SM, Newton DL, Wang ZY, Fu Q, Tchernev VT, Wang M, Schweitzer B, Kingsmore SF, Patel DD, Oppenheim JJ, Howard OM.
Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation.
J Immunol. 173: 6134-42, 2004.
82)  Sun R, Iribarren P, Zhang N, Zhou Y, Gong W, Cho EH, Lockett S, Chertov O, Bednar F, Rogers TJ, Oppenheim JJ, Wang JM.
Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptor.
J. Immunol. 173: 428-36, 2004.
83)  Yang D, Biragyn A, Hoover DM, Lubkowski J, Oppenheim JJ.
Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense.
Annu Rev Immunol. 22: 181-215, 2004.
84)  Zhang N, Rogers TJ, Caterina M, Oppenheim JJ.
Proinflammatory chemokines, such as C-C chemokine ligand 3, desensitize mu-opioid receptors on dorsal root ganglia neurons.
J Immunol. 173: 594-9, 2004.
85)  Felix K, Gerstmeier S, Kyriakopoulos A, Howard OM, Dong HF, Eckhaus M, Behne D, Bornkamm GW, Janz S.
Selenium deficiency abrogates inflammation-dependent plasma cell tumors in mice.
Cancer Res. 64: 2910-7, 2004.
86)  Chen Q, Wade D, Kurosaka K, Wang ZY, Oppenheim JJ, Yang D.
Temporin a and related frog antimicrobial peptides use formyl peptide receptor-like 1 (FPRL-1) as a receptor to chemoattract phagocytes.
J Immunol. 173: 2652-9, 2004.
87)  Yang D, Chen Q, Oppenheim JJ, Kuusela P, Taylor JW, Wade D:.
Temporin/VesCP (T/V)-like antibiotic peptides, derived from frogs and wasps, induce migration of human monocytes and neurtrophils.
Letters Peptide Sci. 10: 99-110, 2004.
88)  Chen X, Krakauer T, Oppenheim JJ, Howard OM.
Yin zi huang, an injectable multicomponent chinese herbal medicine, is a potent inhibitor of T-cell activation.
J Altern Complement Med. 10: 519-26, 2004.
89)  Salcedo R, Zhang X, Young HA, Michael N, Wasserman K, Ma WH, Martins-Green M, Murphy WJ, Oppenheim JJ.
Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells.
Blood. 102: 1966-77, 2003.
90)  Zhang N, Hodge D, Rogers TJ, Oppenheim JJ.
Ca2+-independent protein kinase Cs mediate heterologous desensitization of leukocyte chemokine receptors by opioid receptors.
J. Biol. Chem. 278: 12729-36, 2003.
91)  Grimm MC, Newman R, Hassim Z, Cuan N, Connor SJ, Le Y, Wang JM, Oppenheim JJ, Lloyd AR.
Cutting edge: vasoactive intestinal peptide acts as a potent suppressor of inflammation in vivo by trans-deactivating chemokine receptors.
J. Immunol. 171: 4990-4, 2003.
92)  Lin J, Dong HF, Oppenheim JJ, Howard OM.
Effects of astragali radix on the growth of different cancer cell lines.
World J. Gastroenterol. 9: 670-3, 2003.
93)  Wu Z, Hoover DM, Yang D, Boulègue C, Santamaria F, Oppenheim JJ, Lubkowski J, Lu W.
Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3.
Proc. Natl. Acad. Sci. U.S.A. 100: 8880-5, 2003.
94)  Yang D, Rosenberg HF, Chen Q, Dyer KD, Kurosaka K, Oppenheim JJ.
Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells.
Blood. 102: 3396-403, 2003.
95)  Yang D, Chen Q, Hoover DM, Staley P, Tucker KD, Lubkowski J, Oppenheim JJ.
Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.
J. Leukoc. Biol. 74: 448-55, 2003.
96)  Rugeles MT, Trubey CM, Bedoya VI, Pinto LA, Oppenheim JJ, Rybak SM, Shearer GM.
Ribonuclease is partly responsible for the HIV-1 inhibitory effect activated by HLA alloantigen recognition.
AIDS. 17: 481-6, 2003.
97)  Salcedo R, Oppenheim JJ.
Role of chemokines in angiogenesis: CXCL12/SDF-1 and CXCR4 interaction, a key regulator of endothelial cell responses.
Microcirculation (New York, N.Y. : 1994). 10: 359-70, 2003.
98)  Oppenheim JJ, Biragyn A, Kwak LW, Yang D.
Roles of antimicrobial peptides such as defensins in innate and adaptive immunity.
Ann. Rheum. Dis. 62 Suppl 2: ii17-21, 2003.
99)  Szabo I, Wetzel MA, Zhang N, Steele AD, Kaminsky DE, Chen C, Liu-Chen LY, Bednar F, Henderson EE, Howard OM, Oppenheim JJ, Rogers TJ.
Selective inactivation of CCR5 and decreased infectivity of R5 HIV-1 strains mediated by opioid-induced heterologous desensitization.
J. Leukoc. Biol. 74: 1074-82, 2003.
100)  Chen X, Yang L, Zhang N, Turpin JA, Buckheit RW, Osterling C, Oppenheim JJ, Howard OM.
Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1.
Antimicrob. Agents Chemother. 47: 2810-6, 2003.
101)  Chen X, Beutler JA, McCloud TG, Loehfelm A, Yang L, Dong HF, Chertov OY, Salcedo R, Oppenheim JJ, Howard OM.
Tannic acid is an inhibitor of CXCL12 (SDF-1alpha)/CXCR4 with antiangiogenic activity.
Clin. Cancer Res. 9: 3115-23, 2003.
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This page was last updated on 5/15/2013.