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Our Science – Muegge Website

Kathrin Muegge, M.D.

Selected Publications

1)  Yu W, Briones V, Lister R, McIntosh C, Han Y, Lee EY, Ren J, Terashima M, Leighty RM, Ecker JR, Muegge K.
CG hypomethylation in Lsh-/- mouse embryonic fibroblasts is associated with de novo H3K4me1 formation and altered cellular plasticity.
Proc. Natl. Acad. Sci. U.S.A. 111: 5890-5, 2014.
[Journal]
2)  Briones V, Muegge K.
The ghosts in the machine: DNA methylation and the mystery of differentiation.
Biochim Biophys Acta. 1819: 757-62, 2012.
[Journal]
3)  von Eyss B, Maaskola J, Memczak S, Möllmann K, Schuetz A, Loddenkemper C, Tanh MD, Otto A, Muegge K, Heinemann U, Rajewsky N, Ziebold U.
The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation.
EMBO J. 31: 972-85, 2012.
[Journal]
4)  Tao Y, Xi S, Shan J, Maunakea A, Che A, Briones V, Lee EY, Geiman T, Huang J, Stephens R, Leighty RM, Zhao K, Muegge K.
Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences.
Proc. Natl. Acad. Sci. U.S.A. 108: 5626-31, 2011.
[Journal]
5)  Zeng W, Baumann C, Schmidtmann A, Honaramooz A, Tang L, Bondareva A, Dores C, Fan T, Xi S, Geiman T, Rathi R, de Rooij D, De La Fuente R, Muegge K, Dobrinski I.
Lymphoid-Specific Helicase (HELLS) Is Essential for Meiotic Progression in Mouse Spermatocytes.
Biol. Reprod. 84: 1235-41, 2011.
[Journal]
6)  Tao Y, Liu S, Briones V, Geiman TM, Muegge K.
Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS.
Nucleic Acids Res. 39: 9508-20, 2011.
[Journal]
7)  Geiman TM, Muegge K.
DNA methylation in early development.
Mol. Reprod. Dev. 77: 105-13, 2010.
[Journal]
8)  Tao Y, Xi S, Briones V, Muegge K.
Lsh mediated RNA polymerase II stalling at HoxC6 and HoxC8 involves DNA methylation.
PLoS ONE. 5: e9163, 2010.
[Journal]
9)  Xi S, Geiman TM, Briones V, Tao YG, Xu H, Muegge K.
Lsh Participates in DNA Methylation and Silencing of Stem Cell Genes.
Stem Cells. 27: 2691-702, 2009.
[Journal]
10)  Baumann C, Schmidtmann A, Muegge K, De La Fuente R.
Association of ATRX with pericentric heterochromatin and the Y chromosome of neonatal mouse spermatogonia.
BMC Mol. Biol. 9: 29, 2008.
[Journal]
11)  Fan T, Schmidtmann A, Xi S, Briones V, Zhu H, Suh HC, Gooya J, Keller JR, Xu H, Roayaei J, Anver M, Ruscetti S, Muegge K.
DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development.
Epigenetics. 3: 134-42, 2008.
[Journal]
12)  Muegge K, Xi S, Geiman T.
The see-saw of differentiation: tipping the chromatin balance.
Mol. Interv. 8: 15-8, 2, 2008.
[Journal]
13)  Xi S, Zhu H, Xu H, Schmidtmann A, Geiman TM, Muegge K.
Lsh controls Hox gene silencing during development.
Proc Natl Acad Sci U S A. 104: 14366-71, 2007.
[Journal]
14)  Zhu H, Geiman TM, Xi S, Jiang Q, Schmidtmann A, Chen T, Li E, Muegge K.
Lsh is involved in de novo methylation of DNA.
EMBO J. 25: 335-345, 2006.
[Journal]
15)  De La Fuente R, Baumann C, Fan T, Schmidtmann A, Dobrinski I, Muegge K.
Lsh is required for meiotic chromosome synapsis and retrotransposon silencing in female germ cells.
Nat. Cell Biol. 8: 1448-54, 2006.
[Journal]
16)  Fan T, Hagan JP, Kozlov SV, Stewart CL, Muegge K.
Lsh controls silencing of the imprinted Cdkn1c gene.
Development. 132: 635-44, 2005.
[Journal]
17)  Muegge K.
Lsh, a guardian of heterochromatin at repeat elements.
Biochem Cell Biol. 83: 548-54, 2005.
[Journal]
18)  Huang J, Fan T, Yan Q, Zhu H, Fox S, Issaq HJ, Best L, Gangi L, Munroe D, Muegge K.
Lsh, an epigenetic guardian of repetive elements.
Nucleic Acids Res. 32: 5019-5028, 2004.
[Journal]
19)  Yan Q, Cho E, Lockett S, Muegge K.
Association of Lsh, a regulator of DNA methylation, with pericentrometric heterochromatin is dependent on intact heterochromatin.
Mol. Cell. Biol. 23: 8416-8428, 2003.
[Journal]
20)  Muegge K, Young H, Ruscetti F, Mikovits J.
Epigenetic control during lymphoid development and immune responses: aberrant regulation, viruses, and cancer.
Ann N Y Acad Sci. 983: 55-70, 2003.
[Journal]
21)  Yan Q, Huang J, Fan T, Zhu H, Muegge K.
Lsh, a modulator of CpG methylation, is crucial for normal histone methylation.
EMBO J. 22: 5154-5162, 2003.
[Journal]
22)  Fan T, Yan Q, Huang J, Austin S, Cho E, Ferris D, Muegge K.
Lsh-deficient murine embryonal fibroblasts show reduced proliferation with signs of abnormal mitosis.
Cancer Res. 63: 4677-4683, 2003.
[Journal]
23)  Muegge K.
Modifications of histone cores and tails in V(D)J recombination.
Genome Biol. 4: 211, 2003.
[Journal]
24)  Khaled AR, Li WQ, Huang J, Fry TJ, Khaled AS, Mackall CL, Muegge K, Young HA, Durum SK.
Bax deficiency partially corrects interleukin-7 receptor alpha deficiency.
Immunity. 17: 561-573, 2002.
[Journal]
25)  Muegge K.
Preparing the target for the bullet.
Nature Immunol. 3: 16-17, 2002.
[Journal]
26)  Huang J, Durum SK, Muegge K.
Cutting Edge: Histone acetylation and recombination at the TCR gamma locus follows IL-7 induction.
J. Immunol. 167: 6073-6077, 2001.
[Journal]
27)  Dennis K, Fan T, Geiman T, Yan Q, Muegge K.
Lsh, a member of the SNF2 family, is required for genome wide methylation.
Genes Dev. 15: 2940-2944, 2001.
[Journal]
28)  Dinarello CA, Muegge K, Durum SK.
Measurement of soluble and membrane-bound interleukin 1 using a fibroblast bioassay.
Curr Protoc Immunol. Chapter 6: Unit 6.2, 2001.
[Journal]
29)  Geiman TM, Muegge K.
Lsh, an SNF2/helicase family member, is required for proliferation of mature T lymphocytes.
Proc. Natl. Acad. Sci. USA. 97: 4772-4777, 2000.
[Journal]
30)  Schissel M, Durum SK, Muegge K.
The IL-7 receptor is required for TCR gamma locus accessibility to the V(D)J recombinase.
J. Exp. Med. 191: 1045-1050, 2000.
[Journal]
31)  Geiman TM, Durum SK, Muegge K.
Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh).
Genomics. 54: 477-483, 1998.
[Journal]
32)  Durum SK, Candèias S, Nakajima H, Leonard WJ, Baird AM, Berg LJ, Muegge K.
IL-7 receptor control of T cell receptor gamma gene rearrangement: Role of receptor-associated chains and locus accessibility.
J. Exp. Med. 188: 2233-2241, 1998.
[Journal]
33)  Candéias S, Muegge K, Durum SK.
Junctional diversity in signal joints from T cell receptor beta and delta loci via terminal deoxynuclotidy 1 transferase and exonucleolytic activity.
J. Exp. Med. 184: 1919-1926, 1996.
[Journal]
34)  Muegge K, Vila M, Gusella GL, Musso T, Herrlich P, Stein B, Durum SK.
Interleukin 1 induction of the c-jun promoter.
Proc Natl Acad Sci U S A. 90: 7054-7058, 1993.
[Journal]
35)  Muegge K, Vila MP, Durum SK.
Interleukin-7: A cofactor for V(D)J rearrangement of the T cell receptor beta gene.
Science. 261: 93-95, 1993.
[Journal]
36)  Muegge K, West M, Durum SK.
Recombination sequence-binding protein in thymocytes undergoing T-cell receptor gene rearrangement.
Proc Natl Acad Sci U S A. 90: 4151-4155, 1993.
[Journal]
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This page was last updated on 5/13/2014.