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Our Science – Johnson Website

Peter F. Johnson, Ph.D.

Selected Publications

1)  Huggins CJ, Malik R, Lee S, Salotti J, Thomas S, Martin N, Quiñones OA, Alvord WG, Olanich ME, Keller JR, Johnson PF.
C/EBPγ Suppresses Senescence and Inflammatory Gene Expression by Heterodimerizing with C/EBPβ.
Mol. Cell. Biol. 33: 3242-3258, 2013.
[Journal]
2)  Basu SK, Malik R, Huggins CJ, Lee S, Sebastian T, Sakchaisri K, Quiñones OA, Alvord WG, Johnson PF.
3'UTR elements inhibit Ras-induced C/EBPβ post-translational activation and senescence in tumour cells.
EMBO J. 30: 3714-28, 2011.
[Journal]
3)  Lee S, Shuman JD, Guszczynski T, Sakchaisri K, Sebastian T, Copeland TD, Miller M, Cohen MS, Taunton J, Smart RC, Xiao Z, Yu L, Veenstra TD, Johnson PF.
RSK-mediated phosphorylation in the C/EBPβ leucine zipper regulates DNA binding, dimerization, and growth arrest activity.
Mol. Cell. Biol. 30: 2621-35, 2010.
[Journal]
4)  Sebastian T, Johnson PF.
RasV12-mediated down-regulation of CCAAT/enhancer binding protein β in immortalized fibroblasts requires loss of p19Arf and facilitates bypass of oncogene-induced senescence.
Cancer Res. 69: 2588-98, 2009.
[Journal]
5)  Sebastian T, Malik R, Thomas S, Sage J, Johnson PF.
C/EBPβ cooperates with RB:E2F to implement Ras(V12)-induced cellular senescence.
EMBO J. 24: 3301-3312, 2005.
[Journal]
6)  Yan C, Johnson PF, Tang H, Ye Y, Wu M, Gao H.
CCAAT/enhancer-binding protein δ is a critical mediator of lipopolysaccharide-induced acute lung injury.
Am. J. Pathol. 182: 420-30, 2013.
[Journal]
7)  Duitman J, Hoogendijk AJ, van der Poll T, Spek CA, Yan C, Tang H, Gao H, Johnson PF, Ye Y, Wu M.
CCAAT/Enhancer-Binding Protein δ: Multifaceted Regulator in Respiratory Disease.
Am. J. Pathol. 182: 1459-60, 2013.
[Journal]
8)  Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang Y, Lipton SA, Hong W, Xu H.
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.
Nat Med. 19: 473-480, 2013.
[Journal]
9)  Yan C, Zhu M, Staiger J, Johnson PF, Gao H.
C5a-regulated CCAAT/enhancer-binding proteins β and δ are essential in Fcgamma receptor-mediated inflammatory cytokine and chemokine production in macrophages.
J. Biol. Chem. 287: 3217-30, 2012.
[Journal]
10)  Sønder SU, Paun A, Ha H, Johnson PF, Siebenlist U.
CIKS/Act1-Mediated Signaling by IL-17 Cytokines in Context: Implications for How a CIKS Gene Variant May Predispose to Psoriasis.
J Immunol. 188: 5906-5914, 2012.
[Journal]
11)  Yan C, Wu M, Cao J, Tang H, Zhu M, Johnson PF, Gao H.
Critical Role for CCAAT/Enhancer-Binding Protein β in Immune Complex-Induced Acute Lung Injury.
J. Immunol. 189: 1480-90, 2012.
[Journal]
12)  Sarkar TR, Sharan S, Wang J, Pawar SA, Cantwell CA, Johnson PF, Morrison DK, Wang J, Sterneck E.
Identification of a Src tyrosine kinase/SIAH2 E3 ubiquitin ligase pathway that regulates C/EBPδ expression and contributes to transformation of breast tumor cells.
Mol. Cell. Biol. 32: 320-32, 2012.
[Journal]
13)  Smith AM, Qualls JE, O'Brien K, Balouzian L, Johnson PF, Schultz-Cherry S, Smale ST, Murray PJ.
A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3.
J. Biol. Chem. 286: 23582-90, 2011.
[Journal]
14)  Fan H, Liu Z, Johnson PF, Richards JS.
CCAAT/enhancer-binding proteins (C/EBP) -α and -β are essential for ovulation, luteinization, and the expression of key target genes.
Mol. Endocrinol. 25: 253-68, 2011.
[Journal]
15)  Lee S, Miller M, Shuman JD, Johnson PF.
CCAAT/Enhancer-binding protein β DNA binding is auto-inhibited by multiple elements that also mediate association with p300/CREB-binding protein (CBP).
J. Biol. Chem. 285: 21399-410, 2010.
[Journal]
16)  Sikder H, Zhao Y, Balato A, Chapoval A, Fishelevich R, Gade P, Singh IS, Kalvakolanu DV, Johnson PF, Gaspari AA.
A central role for transcription factor C/EBP-β in regulating CD1d gene expression in human keratinocytes.
J. Immunol. 183: 1657-66, 2009.
[Journal]
17)  Staiger J, Lueben MJ, Berrigan D, Malik R, Perkins SN, Hursting SD, Johnson PF.
C/EBPβ regulates body composition, energy balance-related hormones and tumor growth.
Carcinogenesis. 30: 832-40, 2009.
[Journal]
18)  Fan HY, Liu Z, Shimada M, Sterneck E, Johnson PF, Hedrick SM, Richards JS.
MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility.
Science. 324: 938-41, 2009.
[Journal]
19)  Li Y, Bevilacqua E, Chiribau C, Majumder M, Wang C, Croniger CM, Snider MD, Johnson PF, Hatzoglou M.
Differential control of the CCAAT/enhancer-binding protein β (C/EBPβ) products liver-enriched transcriptional activating protein (LAP) and liver-enriched transcriptional inhibitory protein (LIP) and the regulation of gene expression during the response to endoplasmic reticulum stress.
J. Biol. Chem. 283: 22443-56, 2008.
[Journal]
20)  Cohen TV, Klarmann KD, Sakchaisri K, Cooper JP, Kuhns D, Anver M, Johnson PF, Williams SC, Keller JR, Stewart CL.
The lamin B receptor under transcriptional control of C/EBPε is required for morphological but not functional maturation of neutrophils.
Hum. Mol. Genet. 17: 2921-33, 2008.
[Journal]
21)  Qiao L, Zou C, Shao P, Schaack J, Johnson PF, Shao J.
Transcriptional regulation of fatty acid translocase/CD36 expression by CCAAT/enhancer-binding protein α.
J. Biol. Chem. 283: 8788-95, 2008.
[Journal]
22)  Uittenbogaard M, Martinka DL, Johnson PF, Vinson C, Chiaramello A.
5'UTR of the neurogenic bHLH Nex1/MATH-2/NeuroD6 gene is regulated by two distinct promoters through CRE and C/EBP binding sites.
J. Neurosci. Res. 85: 1-18, 2007.
[Journal]
23)  Lopez AB, Wang C, Huang CC, Yaman I, Li Y, Chakravarty K, Johnson PF, Chiang CM, Snider MD, Wek RC, Hatzoglou M.
A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation.
Biochem. J. 402: 163-73, 2007.
[Journal]
24)  Spooner CJ, Sebastian T, Shuman JD, Durairaj S, Guo X, Johnson PF, Schwartz RC.
C/EBPβ serine 64, a phosphoacceptor site, has a critical role in LPS-induced IL-6 and MCP-1 transcription.
Cytokine. 37: 119-27, 2007.
[Journal]
25)  Spooner CJ, Guo X, Johnson PF, Schwartz RC.
Differential roles of C/EBPβ regulatory domains in specifying MCP-1 and IL-6 transcription.
Mol. Immunol. 44: 1384-92, 2007.
[Journal]
26)  Loomis KD, Zhu S, Yoon K, Johnson PF, Smart RC.
Genetic ablation of CCAAT/enhancer binding protein alpha in epidermis reveals its role in suppression of epithelial tumorigenesis.
Cancer Res. 67: 6768-76, 2007.
[Journal]
27)  Suh HC, Gooya J, Renn K, Friedman AD, Johnson PF, Keller JR.
C/EBPα determines hematopoietic cell fate in multipotential progenitor cells by inhibiting erythroid differentiation and inducing myeloid differentiation.
Blood. 107: 4308-16, 2006.
[Journal]
28)  Mantena SR, Kannan A, Cheon Y, Li Q, Johnson PF, Bagchi IC, Bagchi MK.
C/EBPβ is a critical mediator of steroid hormone-regulated cell proliferation and differentiation in the uterine epithelium and stroma.
Proc Natl Acad Sci U S A. 103: 1870-5, 2006.
[Journal]
29)  McCauslin CS, Heath V, Colangelo AM, Malik R, Lee S, Mallei A, Mocchetti I, Johnson PF.
C/EBPδ and CREB mediate inducible expression of the nerve growth factor gene in the central nervous system.
J Biol Chem. 281: 17681-17688, 2006.
[Journal]
30)  Kapadia R, Tureyen K, Bowen KK, Kalluri H, Johnson PF, Vemuganti R.
Decreased brain damage and curtailed inflammation in transcription factor CCAAT/enhancer binding protein β knockout mice following transient focal cerebral ischemia.
J. Neurochem. 98: 1718-31, 2006.
[Journal]
31)  Sebastian T, Johnson PF.
Stop and go: anti-proliferative and mitogenic functions of the transcription factor C/EBPβ.
Cell Cycle. 5: 953-7, 2006.
[Journal]
32)  Roy SK, Shuman JD, Platanias LC, Shapiro PS, Reddy SP, Johnson PF, Kalvakolanu DV.
A role for mixed lineage kinases in regulating transcription factor CCAAT/enhancer-binding protein-β-dependent gene expression in response to interferon-γ.
J Biol Chem. 280: 24462-71, 2005.
[Journal]
33)  Johnson PF.
Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors.
J Cell Sci. 118: 2545-55, 2005.
[Journal]
34)  Burkart AD, Mukherjee A, Sterneck E, Johnson PF, Mayo KE.
Repression of the inhibin α-subunit gene by the transcription factor CCAAT/enhancer-binding protein-β.
Endocrinology. 146: 1909-21, 2005.
[Journal]
35)  Wessells J, Baer M, Young HA, Claudio E, Brown K, Siebenlist U, Johnson PF.
BCL-3 and NF-κB p50 attenuate LPS-induced inflammatory responses in macrophages.
J Biol Chem. 279: 49995-50003, 2004.
[Journal]
36)  Heath V, Suh HC, Holman M, Renn K, Gooya JM, Parkin S, Klarmann KD, Ortiz M, Johnson P, Keller J.
C/EBPα Deficiency Results in Hyperproliferation of Hematopoietic Progenitor Cells and Disrupts Macrophage Development In Vitro and In Vivo.
Blood. 104: 1639-1647, 2004.
[Journal]
37)  Shuman JD, Sebastian T, Kaldis P, Copeland TD, Zhu S, Smart RC, Johnson PF.
Cell cycle-dependent phosphorylation of C/EBPβ mediates oncogenic cooperativity between C/EBPβ and H-RasV12.
Mol Cell Biol. 24: 7380-91, 2004.
[Journal]
38)  Wessells J, Yakar S, Johnson PF.
Critical Prosurvival Roles for C/EBPβ and Insulin-Like Growth Factor I in Macrophage Tumor Cells.
Mol Cell Biol. 24: 3238-3250, 2004.
[Journal]
39)  Colangelo AM, Mallei A, Johnson PF, Mocchetti I.
Synergistic effect of dexamethasone and β-adrenergic receptor agonists on the nerve growth factor gene transcription.
Brain Res Mol Brain Res. 124: 97-104, 2004.
[Journal]
40)  Gigliotti AP, Johnson PF, Sterneck E, DeWille JW.
Nulliparous CCAAT/enhancer binding protein δ (C/EBPδ) knockout mice exhibit mammary gland ductal hyperlasia.
Exp Biol Med (Maywood). 228: 278-85, 2003.
[Journal]
41)  Miller M, Shuman JD, Sebastian T, Dauter Z, Johnson PF.
Structural basis for DNA recognition by the basic region leucine zipper transcription factor CCAAT/enhancer-binding protein α.
J Biol Chem. 278: 15178-84, 2003.
[Journal]
42)  Ménard C, Hein P, Paquin A, Savelson A, Yang XM, Lederfein D, Barnabé-Heider F, Mir AA, Sterneck E, Peterson AC, Johnson PF, Vinson C, Miller FD.
An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis.
Neuron. 36: 597-610, 2002.
[Journal]
43)  Gao H, Parkin S, Johnson PF, Schwartz RC.
C/EBPγ has a stimulatory role on the IL-6 and IL-8 promoters.
J Biol Chem. 277: 38827-37, 2002.
[Journal]
44)  Zhu S, Yoon K, Sterneck E, Johnson PF, Smart RC.
CCAAT/enhancer binding protein-β is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling.
Proc Natl Acad Sci U S A. 99: 207-12, 2002.
[Journal]
45)  Roy SK, Hu J, Meng Q, Xia Y, Shapiro PS, Reddy SP, Platanias LC, Lindner DJ, Johnson PF, Pritchard C, Pagés G, Pouyssegur J, Kalvakolanu DV.
MEKK1 plays a critical role in activating the transcription factor C/EBP-β-dependent gene expression in response to IFN-γ.
Proc Natl Acad Sci U S A. 99: 7945-50, 2002.
[Journal]
46)  Parkin SE, Baer M, Copeland TD, Schwartz RC, Johnson PF.
Regulation of CCAAT/enhancer-binding protein (C/EBP) activator proteins by heterodimerization with C/EBPγ (Ig/EBP).
J Biol Chem. 277: 23563-72, 2002.
[Journal]
47)  Kim J, Cantwell CA, Johnson PF, Pfarr CM, Williams SC.
Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation.
J Biol Chem. 277: 38037-44, 2002.
[Journal]
48)  Butcher BA, Kim L, Johnson PF, Denkers EY.
Toxoplasma gondii tachyzoites inhibit proinflammatory cytokine induction in infected macrophages by preventing nuclear translocation of the transcription factor NF-κB.
J Immunol. 167: 2193-201, 2001.
[Journal]
49)  Baer M, Johnson PF.
Generation of truncated C/EBPβ isoforms by in vitro proteolysis.
J Biol Chem. 275: 26582-90, 2000.
[Journal]
50)  Robinson GW, Hennighausen L, Johnson PF.
Side-branching in the mammary gland: the progesterone-Wnt connection.
Genes Dev. 14: 889-94, 2000.
[Journal]
51)  Baer M, Nedospasov S, Johnson PF.
Attenuation of tumor necrosis factor α gene transcription in macrophages by an autocrine factor.
Cold Spring Harb Symp Quant Biol. 64: 437-44, 1999.
[Journal]
52)  Sterneck E, Paylor R, Jackson-Lewis V, Libbey M, Przedborski S, Tessarollo L, Crawley JN, Johnson PF.
Selectively enhanced contextual fear conditioning in mice lacking the transcriptional regulator CCAAT/enhancer binding protein δ.
Proc Natl Acad Sci U S A. 95: 10908-13, 1998.
[Journal]
53)  Baer M, Dillner A, Schwartz RC, Sedon C, Nedospasov S, Johnson PF.
Tumor necrosis factor α transcription in macrophages is attenuated by an autocrine factor that preferentially induces NF-κB p50.
Mol Cell Biol. 18: 5678-89, 1998.
[Journal]
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This page was last updated on 12/3/2013.