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Our Science – Tessarollo Website

Lino Tessarollo, Ph.D.

Selected Publications

1)  Yanpallewar SU, Barrick CA, Buckley H, Becker J, Tessarollo L.
Deletion of the BDNF Truncated Receptor TrkB.T1 Delays Disease Onset in a Mouse Model of Amyotrophic Lateral Sclerosis.
PLoS ONE. 7: e39946, 2012.
2)  Yanpallewar SU, Barrick CA, Palko ME, Fulgenzi G, Tessarollo L.
Tamalin is a critical mediator of electroconvulsive shock-induced adult neuroplasticity.
J. Neurosci. 32: 2252-62, 2012.
3)  Baydyuk M, Xie Y, Tessarollo L, Xu B.
Midbrain-derived neurotrophins support survival of immature striatal projection neurons.
J. Neurosci. 33: 3363-9, 2013.
4)  Puverel S, Tessarollo L.
RanBPM, a scaffolding protein for gametogenesis.
Curr. Top. Dev. Biol. 102: 357-84, 2013.
5)  Liu Y, Rutlin M, Huang S, Barrick CA, Wang F, Jones KR, Tessarollo L, Ginty DD.
Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland.
Science. 338: 1357-60, 2012.
6)  Di Lieto A, Rantamäki T, Vesa L, Yanpallewar S, Antila H, Lindholm J, Rios M, Tessarollo L, Castrén E.
The responsiveness of TrkB to BDNF and antidepressant drugs is differentially regulated during mouse development.
PLoS ONE. 7: e32869, 2012.
7)  Arnold ES, Ling SC, Huelga SC, Lagier-Tourenne C, Polymenidou M, Ditsworth D, Kordasiewicz HB, McAlonis-Downes M, Platoshyn O, Parone PA, Da Cruz S, Clutario KM, Swing D, Tessarollo L, Marsala M, Shaw CE, Yeo GW, Cleveland DW.
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.
Proc. Natl. Acad. Sci. U.S.A. 110: E736-45, 2013.
8)  Kiviranta R, Yamana K, Saito H, Ho DK, Laine J, Tarkkonen K, Nieminen-Pihala V, Hesse E, Correa D, Määttä J, Tessarollo L, Rosen ED, Horne WC, Jenkins NA, Copeland NG, Warming S, Baron R.
Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages.
J. Exp. Med. [Epub ahead of print], 2013.
9)  Takeda H, Koso H, Tessarollo L, Copeland NG, Jenkins NA.
Musashi1-CreER(T2) : a new cre line for conditional mutagenesis in neural stem cells.
Genesis. 51: 128-34, 2013.
10)  Risinger JI, Custer M, Feigenbaum L, Mark Simpson R, Hoover SB, Webster JD, Chandramouli GV, Tessarollo L, Barrett JC.
Normal viability of Kai1/Cd82 deficient mice.
Mol. Carcinog. [Epub ahead of print], 2013.
11)  Chen K, Liu M, Liu Y, Wang C, Yoshimura T, Gong W, Le Y, Tessarollo L, Wang JM.
Signal relay by CCR2 and formylpeptide receptor-2 (Fpr2) in the recruitment of monocyte-derived dendritic cells in allergic airway inflammation.
J. Biol. Chem. [Epub ahead of print], 2013.
12)  Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, Taniguchi K, Yu GY, Osterreicher CH, Hung KE, Datz C, Feng Y, Fearon ER, Oukka M, Tessarollo L, Coppola V, Yarovinsky F, Cheroutre H, Eckmann L, Trinchieri G, Karin M.
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Nature. 491: 254-8, 2012.
13)  Nie Z, Hu G, Wei G, Cui K, Yamane A, Resch W, Wang R, Green DR, Tessarollo L, Casellas R, Zhao K, Levens D.
c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells.
Cell. 151: 68-79, 2012.
14)  Gaiser MR, Lämmermann T, Feng X, Igyarto BZ, Kaplan DH, Tessarollo L, Germain RN, Udey MC.
Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo.
Proc. Natl. Acad. Sci. U.S.A. 109: E889-97, 2012.
15)  Berquam-Vrieze KE, Swing DA, Tessarollo L, Dupuy AJ.
Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1.
Genesis. 50: 112-8, 2012.
16)  Diril MK, Ratnacaram CK, Padmakumar VC, Du T, Wasser M, Coppola V, Tessarollo L, Kaldis P.
Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration.
Proc. Natl. Acad. Sci. U.S.A. 109: 3826-31, 2012.
17)  Chiang YJ, Difilippantonio MJ, Tessarollo L, Morse HC, Hodes RJ.
Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas.
PLoS ONE. 7: e49305, 2012.
18)  Biswas K, Das R, Eggington JM, Qiao H, North SL, Stauffer S, Burkett S, Martin BK, Southon E, Sizemore SC, Pruss D, Bowles KR, Roa BB, Hunter N, Tessarollo L, Wenstrup RJ, Byrd RA, Sharan SK.
Functional evaluation of BRCA2 variants mapping to the PALB2 binding and C-terminal DNA binding domains using a mouse ES cell-based assay.
Hum. Mol. Genet. 21: 3993-4006, 2012.
19)  Dorsey SG, Lovering RM, Renn CL, Leitch CC, Liu X, Tallon LJ, Sadzewicz LD, Pratap A, Ott S, Sengamalay N, Jones KM, Barrick C, Fulgenzi G, Becker J, Voelker K, Talmadge R, Harvey BK, Wyatt RM, Vernon-Pitts E, Zhang C, Shokat K, Fraser-Liggett C, Balice-Gordon RJ, Tessarollo L, Ward CW.
Genetic deletion of trkB.T1 increases neuromuscular function.
Am. J. Physiol. Cell Physiol. 302: C141-53, 2012.
20)  Unnisa Z, Clark JP, Roychoudhury J, Thomas E, Tessarollo L, Copeland NG, Jenkins NA, Grimes HL, Kumar AR.
Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress.
Blood. 120: 4973-81, 2012.
21)  Siao CJ, Lorentz CU, Kermani P, Marinic T, Carter J, McGrath K, Padow VA, Mark W, Falcone DJ, Cohen-Gould L, Parrish DC, Habecker BA, Nykjaer A, Ellenson LH, Tessarollo L, Hempstead BL.
ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation.
J. Exp. Med. 209: 2291-305, 2012.
22)  Padmakumar VC, Speer K, Pal-Ghosh S, Masiuk K, Ryscavage A, Dengler S, Hwang S, Edwards J, Coppola V, Tessarollo L, Stepp MA, Yuspa SH.
Spontaneous Skin Erosions and Reduced Skin and Corneal Wound Healing Characterize CLIC4(NULL) Mice.
Am. J. Pathol. 181: 74-84, 2012.
23)  Baba M, Keller JR, Sun H, Resch W, Kuchen S, Suh HC, Hasumi H, Hasumi Y, Kieffer-Kwon K, Gonzalez CG, Hughes RM, Klein ME, Oh HF, Bible P, Southon E, Tessarollo L, Schmidt LS, Linehan WM, Casellas R.
The Folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dube syndrome is required for mouse B cell development.
Blood. 120: 1254-61, 2012.
24)  Gegonne A, Tai X, Zhang J, Wu G, Zhu J, Yoshimoto A, Hanson J, Cultraro C, Chen QR, Guinter T, Yang Z, Hathcock K, Singer A, Rodriguez-Canales J, Tessarollo L, Mackem S, Meerzaman D, Buetow K, Singer DS.
The general transcription factor TAF7 is essential for embryonic development but not essential for the survival or differentiation of mature T cells.
Mol. Cell. Biol. 32: 1984-97, 2012.
25)  Waldron-Roby E, Ratovitski T, Wang X, Jiang M, Watkin E, Arbez N, Graham RK, Hayden MR, Hou Z, Mori S, Swing D, Pletnikov M, Duan W, Tessarollo L, Ross CA.
Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.
J. Neurosci. 32: 183-93, 2012.
26)  Lai KO, Wong AS, Cheung MC, Xu P, Liang Z, Lok KC, Xie H, Palko ME, Yung WH, Tessarollo L, Cheung ZH, Ip NY.
TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory.
Nat. Neurosci. 15: 1506-15, 2012.
27)  Zhang S, Readinger JA, DuBois W, Janka-Junttila M, Robinson R, Pruitt M, Bliskovsky V, Wu JZ, Sakakibara K, Patel J, Parent CA, Tessarollo L, Schwartzberg PL, Mock BA.
Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production.
Blood. 117: 1228-38, 2011.
28)  Suh YH, Yoshimoto-Furusawa A, Weih KA, Tessarollo L, Roche KW, Mackem S, Roche PA.
Deletion of SNAP-23 results in pre-implantation embryonic lethality in mice.
PLoS ONE. 6: e18444, 2011.
29)  Graciotti L, Becker J, Granata AL, Procopio AD, Tessarollo L, Fulgenzi G.
Dystrophin is required for the normal function of the cardio-protective K(ATP) channel in cardiomyocytes.
PLoS ONE. 6: e27034, 2011.
30)  Kiris E, Nuss JE, Burnett JC, Kota KP, Koh DC, Wanner LM, Torres-Melendez E, Gussio R, Tessarollo L, Bavari S.
Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery.
Stem Cell Res. 6: 195-205, 2011.
31)  Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B.
GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.
Proc. Natl. Acad. Sci. U.S.A. 108: 5759-64, 2011.
32)  Avdoshina V, Becker J, Campbell LA, Parsadanian M, Mhyre T, Tessarollo L, Mocchetti I.
Neurotrophins modulate the expression of chemokine receptors in the brain.
J. Neurovirol. 17: 58-62, 2011.
33)  Tebbenkamp AT, Swing D, Tessarollo L, Borchelt DR.
Premature death and neurologic abnormalities in transgenic mice expressing a mutant huntingtin exon-2 fragment.
Hum. Mol. Genet. 20: 1633-42, 2011.
34)  Puverel S, Barrick C, Dolci S, Coppola V, Tessarollo L.
RanBPM is essential for mouse spermatogenesis and oogenesis.
Development. 138: 2511-21, 2011.
35)  Yu T, Calvo L, Anta B, López-Benito S, Southon E, Chao MV, Tessarollo L, Arévalo JC.
Regulation of trafficking of activated TrkA is critical for NGF-mediated functions.
Traffic. 12: 521-34, 2011.
36)  Vaegter CB, Jansen P, Fjorback AW, Glerup S, Skeldal S, Kjolby M, Richner M, Erdmann B, Nyengaard JR, Tessarollo L, Lewin GR, Willnow TE, Chao MV, Nykjaer A.
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.
Nat. Neurosci. 14: 54-61, 2011.
37)  Buttermore ED, Dupree JL, Cheng J, An X, Tessarollo L, Bhat MA.
The cytoskeletal adaptor protein band 4.1B is required for the maintenance of paranodal axoglial septate junctions in myelinated axons.
J. Neurosci. 31: 8013-24, 2011.
38)  Tebbenkamp AT, Green C, Xu G, Denovan-Wright EM, Rising AC, Fromholt SE, Brown HH, Swing D, Mandel RJ, Tessarollo L, Borchelt DR.
Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative.
Hum. Mol. Genet. 20: 2770-82, 2011.
39)  Chen K, Le Y, Liu Y, Gong W, Ying G, Huang J, Yoshimura T, Tessarollo L, Wang JM.
A critical role for the g protein-coupled receptor mFPR2 in airway inflammation and immune responses.
J. Immunol. 184: 3331-5, 2010.
40)  Lefevre GM, Patel SR, Kim D, Tessarollo L, Dressler GR.
Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype.
PLoS Genet. 6: e1001142, 2010.
41)  Tessarollo L.
Brain disorders: getting 'Down' to the gene.
Nat. Neurosci. 13: 909-10, 2010.
42)  Takizawa M, Kim JS, Tessarollo L, McNeil N, Waldschmidt TJ, Casellas R, Ried T, Janz S.
Genetic reporter system for oncogenic Igh-Myc translocations in mice.
Oncogene. 29: 4113-20, 2010.
43)  Bai Y, Shi Z, Zhuo Y, Liu J, Malakhov A, Ko E, Burgess K, Schaefer H, Esteban PF, Tessarollo L, Saragovi HU.
In glaucoma the up-regulated truncated TrkC.T1 receptor isoform in glia causes increased TNF-{alpha} production, leading to retinal ganglion cell death.
Invest. Ophthalmol. Vis. Sci. 51: 6639-51, 2010.
44)  Wirth EK, Conrad M, Winterer J, Wozny C, Carlson BA, Roth S, Schmitz D, Bornkamm GW, Coppola V, Tessarollo L, Schomburg L, Köhrle J, Hatfield DL, Schweizer U.
Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration.
FASEB J. 24: 844-52, 2010.
45)  Satyanarayana A, Gudmundsson KO, Chen X, Coppola V, Tessarollo L, Keller JR, Hou SX.
RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis.
Blood. 116: 2921-31, 2010.
46)  Nelson TM, Lopezjimenez ND, Tessarollo L, Inoue M, Bachmanov AA, Sullivan SL.
Taste function in mice with a targeted mutation of the pkd1l3 gene.
Chem. Senses. 35: 565-77, 2010.
47)  Arévalo JC, Wu SH, Takahashi T, Zhang H, Yu T, Yano H, Milner TA, Tessarollo L, Ninan I, Arancio O, Chao MV.
The ARMS/Kidins220 scaffold protein modulates synaptic transmission.
Mol. Cell. Neurosci. 45: 92-100, 2010.
48)  Keng VW, Villanueva A, Chiang DY, Dupuy AJ, Ryan BJ, Matise I, Silverstein KA, Sarver A, Starr TK, Akagi K, Tessarollo L, Collier LS, Powers S, Lowe SW, Jenkins NA, Copeland NG, Llovet JM, Largaespada DA.
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.
Nat. Biotechnol. 27: 264-74, 2009.
49)  Starr TK, Allaei R, Silverstein KA, Staggs RA, Sarver AL, Bergemann TL, Gupta M, O'Sullivan MG, Matise I, Dupuy AJ, Collier LS, Powers S, Oberg AL, Asmann YW, Thibodeau SN, Tessarollo L, Copeland NG, Jenkins NA, Cormier RT, Largaespada DA.
A transposon-based genetic screen in mice identifies genes altered in colorectal cancer.
Science. 323: 1747-50, 2009.
50)  Nagao K, Zhu J, Heneghan MB, Hanson JC, Morasso MI, Tessarollo L, Mackem S, Udey MC.
Abnormal placental development and early embryonic lethality in EpCAM-null mice.
PLoS ONE. 4: e8543, 2009.
51)  Wu SH, Arévalo JC, Sarti F, Tessarollo L, Gan WB, Chao MV.
Ankyrin Repeat-rich Membrane Spanning/Kidins220 protein regulates dendritic branching and spine stability in vivo.
Dev Neurobiol. 69: 547-557, 2009.
52)  Carim-Todd L, Bath KG, Fulgenzi G, Yanpallewar S, Jing D, Barrick CA, Becker J, Buckley H, Dorsey SG, Lee FS, Tessarollo L.
Endogenous truncated TrkB.T1 receptor regulates neuronal complexity and TrkB kinase receptor function in vivo.
J. Neurosci. 29: 678-85, 2009.
53)  Tessarollo L, Palko ME, Akagi K, Coppola V.
Gene targeting in mouse embryonic stem cells.
Methods Mol. Biol. 530: 141-64, 2009.
54)  Cullen M, Seaman S, Chaudhary A, Yang MY, Hilton MB, Logsdon D, Haines DC, Tessarollo L, St Croix B.
Host-derived tumor endothelial marker 8 promotes the growth of melanoma.
Cancer Res. 69: 6021-6, 2009.
55)  Reid SW, Tessarollo L.
Isolation, microinjection and transfer of mouse blastocysts.
Methods Mol. Biol. 530: 269-85, 2009.
56)  Southon E, Tessarollo L.
Manipulating mouse embryonic stem cells.
Methods Mol. Biol. 530: 165-85, 2009.
57)  Wang X, Rao RP, Kosakowska-Cholody T, Masood MA, Southon E, Zhang H, Berthet C, Nagashim K, Veenstra TK, Tessarollo L, Acharya U, Acharya JK.
Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice.
J. Cell Biol. 184: 143-58, 2009.
58)  Takahashi M, Galligan C, Tessarollo L, Yoshimura T.
Monocyte chemoattractant protein-1 (MCP-1), not MCP-3, is the primary chemokine required for monocyte recruitment in mouse peritonitis induced with thioglycollate or zymosan A.
J. Immunol. 183: 3463-71, 2009.
59)  Yang J, Siao CJ, Nagappan G, Marinic T, Jing D, McGrath K, Chen ZY, Mark W, Tessarollo L, Lee FS, Lu B, Hempstead BL.
Neuronal release of proBDNF.
Nat. Neurosci. 12: 113-5, 2009.
60)  Ueda T, Furusawa T, Kurahashi T, Tessarollo L, Bustin M.
The nucleosome binding protein HMGN3 modulates the transcription profile of pancreatic beta cells and affects insulin secretion.
Mol. Cell. Biol. 29: 5264-76, 2009.
61)  Zeng H, Horie K, Madisen L, Pavlova MN, Gragerova G, Rohde AD, Schimpf BA, Liang Y, Ojala E, Kramer F, Roth P, Slobodskaya O, Dolka I, Southon EA, Tessarollo L, Bornfeldt KE, Gragerov A, Pavlakis GN, Gaitanaris GA.
An inducible and reversible mouse genetic rescue system.
PLoS Genet. 4: e1000069, 2008.
62)  Taylor GA, Rodriguiz RM, Greene RI, Daniell X, Henry SC, Crooks KR, Kotloski R, Tessarollo L, Phillips LE, Wetsel WC.
Behavioral characterization of P311 knockout mice.
Genes Brain Behav. 7: 786-95, 2008.
63)  Jiang X, Tian F, Du Y, Copeland NG, Jenkins NA, Tessarollo L, Wu X, Pan H, Hu XZ, Xu K, Kenney H, Egan SE, Turley H, Harris AL, Marini AM, Lipsky RH.
BHLHB2 controls Bdnf promoter 4 activity and neuronal excitability.
J. Neurosci. 28: 1118-30, 2008.
64)  Ahmed F, Tessarollo L, Thiele C, Mocchetti I.
Brain-derived neurotrophic factor modulates expression of chemokine receptors in the brain.
Brain Res. 1227: 1-11, 2008.
65)  Wang L, Wildt KF, Zhu J, Zhang X, Feigenbaum L, Tessarollo L, Paul WE, Fowlkes BJ, Bosselut R.
Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells.
Nat. Immunol. 9: 1122-30, 2008.
66)  Landry J, Sharov AA, Piao Y, Sharova LV, Xiao H, Southon E, Matta J, Tessarollo L, Zhang YE, Ko MS, Kuehn MR, Yamaguchi TP, Wu C.
Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells.
PLoS Genet. 4: e1000241, 2008.
67)  Rivera J, Tessarollo L.
Genetic background and the dilemma of translating mouse studies to humans.
Immunity. 28: 1-4, 2008.
68)  Satyanarayana A, Berthet C, Lopez-Molina J, Coppola V, Tessarollo L, Kaldis P.
Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2.
Development. 135: 3389-400, 2008.
69)  Esteban PF, Caprari P, Yoon HY, Randazzo PA, Tessarollo L.
In vitro and in vivo analysis of neurotrophin-3 activation of Arf6 and Rac-1.
Meth. Enzymol. 438: 171-83, 2008.
70)  Baba M, Furihata M, Hong SB, Tessarollo L, Haines DC, Southon E, Patel V, Igarashi P, Alvord WG, Leighty R, Yao M, Bernardo M, Ileva L, Choyke P, Warren MB, Zbar B, Linehan WM, Schmidt LS.
Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys.
J. Natl. Cancer Inst. 100: 140-54, 2008.
71)  Fernández AP, Serrano J, Tessarollo L, Cuttitta F, Martínez A.
Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions.
Proc. Natl. Acad. Sci. U.S.A. 105: 12581-6, 2008.
72)  Chiang YJ, Hsiao SJ, Yver D, Cushman SW, Tessarollo L, Smith S, Hodes RJ.
Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.
PLoS ONE. 3: e2639, 2008.
73)  Wang L, Wildt KF, Castro E, Xiong Y, Feigenbaum L, Tessarollo L, Bosselut R.
The Zinc Finger Transcription Factor Zbtb7b Represses CD8-Lineage Gene Expression in Peripheral CD4(+) T Cells.
Immunity. 29: 876-87, 2008.
74)  Ivanova AV, Ivanov SV, Pascal V, Lumsden JM, Ward JM, Morris N, Tessarollo L, Anderson SK, Lerman MI.
Autoimmunity, spontaneous tumourigenesis, and IL-15 insufficiency in mice with a targeted disruption of the tumour suppressor gene Fus1.
J. Pathol. 211: 591-601, 2007.
75)  Nosheny RL, Ahmed F, Yakovlev A, Meyer EM, Ren K, Tessarollo L, Mocchetti I.
Brain-derived neurotrophic factor prevents the nigrostriatal degeneration induced by human immunodeficiency virus-1 glycoprotein 120 in vivo.
Eur. J. Neurosci. 25: 2275-84, 2007.
76)  Bong YS, Lee HS, Carim-Todd L, Mood K, Nishanian TG, Tessarollo L, Daar IO.
ephrinB1 signals from the cell surface to the nucleus by recruitment of STAT3.
Proc. Natl. Acad. Sci. U.S.A. 104: 17305-10, 2007.
77)  Slape C, Chung YJ, Soloway PD, Tessarollo L, Aplan PD.
Mouse embryonic stem cells that express a NUP98-HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL.
Leukemia. 21: 1239-48, 2007.
78)  Kuznetsov S, Pellegrini M, Shuda K, Fernandez-Capetillo O, Liu Y, Martin BK, Burkett S, Southon E, Pati D, Tessarollo L, West SC, Donovan PJ, Nussenzweig A, Sharan SK.
RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females.
J. Cell Biol. 176: 581-92, 2007.
79)  Esteban PF, Yoon HY, Becker J, Dorsey SG, Caprari P, Palko ME, Coppola V, Saragovi HU, Randazzo PA, Tessarollo L.
A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin.
J. Cell Biol. 173: 291-9, 2006.
80)  Rossi C, Angelucci A, Costantin L, Braschi C, Mazzantini M, Babbini F, Fabbri ME, Tessarollo L, Maffei L, Berardi N, Caleo M.
Brain-derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment.
Eur. J. Neurosci. 24: 1850-6, 2006.
81)  Garcia-Fresco GP, Sousa AD, Pillai AM, Moy SS, Crawley JN, Tessarollo L, Dupree JL, Bhat MA.
Disruption of axo-glial junctions causes cytoskeletal disorganization and degeneration of Purkinje neuron axons.
Proc. Natl. Acad. Sci. U.S.A. 103: 5137-42, 2006.
82)  Chiang YJ, Nguyen ML, Gurunathan S, Kaminker P, Tessarollo L, Campisi J, Hodes RJ.
Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice.
Mol. Cell. Biol. 26: 2037-43, 2006.
83)  Dorsey SG, Renn CL, Carim-Todd L, Barrick CA, Bambrick L, Krueger BK, Ward CW, Tessarollo L.
In Vivo Restoration of Physiological Levels of Truncated TrkB.T1 Receptor Rescues Neuronal Cell Death in a Trisomic Mouse Model.
Neuron. 51: 21-8, 2006.
84)  Liepinsh DJ, Grivennikov SI, Klarmann KD, Lagarkova MA, Drutskaya MS, Lockett SJ, Tessarollo L, McAuliffe M, Keller JR, Kuprash DV, Nedospasov SA.
Novel lymphotoxin alpha (LTalpha) knockout mice with unperturbed tumor necrosis factor expression: reassessing LTalpha biological functions.
Mol. Cell. Biol. 26: 4214-25, 2006.
85)  Coppola V, Barrick CA, Bobisse S, Rodriguez-Galan MC, Pivetta M, Reynolds D, Howard OM, Palko ME, Esteban PF, Young HA, Rosato A, Tessarollo L.
The scaffold protein cybr is required for cytokine-modulated trafficking of leukocytes in vivo.
Mol. Cell. Biol. 26: 5249-58, 2006.
86)  Grivennikov SI, Tumanov AV, Liepinsh DJ, Kruglov AA, Marakusha BI, Shakhov AN, Murakami T, Drutskaya LN, Förster I, Clausen BE, Tessarollo L, Ryffel B, Kuprash DV, Nedospasov SA.
Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects.
Immunity. 22: 93-104, 2005.
87)  Park SS, Kim JS, Tessarollo L, Owens JD, Peng L, Han SS, Tae Chung S, Torrey TA, Cheung WC, Polakiewicz RD, McNeil N, Ried T, Mushinski JF, Morse HC, Janz S.
Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice.
Cancer Res. 65: 1306-15, 2005.
88)  Fritzsch B, Pauley S, Matei V, Katz DM, Xiang M, Tessarollo L.
Mutant mice reveal the molecular and cellular basis for specific sensory connections to inner ear epithelia and primary nuclei of the brain.
Hear. Res. 206: 52-63, 2005.
89)  Kuprash DV, Tumanov AV, Liepinsh DJ, Koroleva EP, Drutskaya MS, Kruglov AA, Shakhov AN, Southon E, Murphy WJ, Tessarollo L, Grivennikov SI, Nedospasov SA.
Novel tumor necrosis factor-knockout mice that lack Peyer's patches.
Eur. J. Immunol. 35: 1592-600, 2005.
90)  Wolff L, Garin MT, Koller R, Bies J, Tessarollo L, Anver MR, Powell D, Perella C.
A novel retrovirus provides the cooperating oncogenic event(s) required to demonstrate the tumor suppressor activity of p15Ink4b in myeloid cells in vivo.
Blood Cells Mol. Dis. 32: 226-31, 2004.
91)  Coppola V, Barrick CA, Southon EA, Celeste A, Wang K, Chen B, Haddad el-B, Yin J, Nussenzweig A, Subramaniam A, Tessarollo L.
Ablation of TrkA function in the immune system causes B cell abnormalities.
Development. 131: 5185-95, 2004.
92)  Graveel C, Su Y, Koeman J, Wang LM, Tessarollo L, Fiscella M, Birchmeier C, Swiatek P, Bronson R, Vande Woude G.
Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele.
Proc. Natl. Acad. Sci. U.S.A. 101: 17198-203, 2004.
93)  Akassoglou K, Malester B, Xu J, Tessarollo L, Rosenbluth J, Chao MV.
Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration.
Proc Natl Acad Sci U S A. 101: 5075-5080, 2004.
94)  Sharan SK, Pyle A, Coppola V, Babus J, Swaminathan S, Benedict J, Swing D, Martin BK, Tessarollo L, Evans JP, Flaws JA, Handel MA.
BRCA2 deficiency in mice leads to meiotic impairment and infertility.
Development. 131: 131-42, 2004.
95)  Ivanov SV, Ward JM, Tessarollo L, McAreavey D, Sachdev V, Fananapazir L, Banks MK, Morris N, Djurickovic D, Devor-Henneman DE, Wei MH, Alvord GW, Gao B, Richardson JA, Minna JD, Rogawski MA, Lerman MI.
Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene.
Am. J. Pathol. 165: 1007-18, 2004.
96)  Coppola V, Tessarollo L.
Control of hyperphagia prevents obesity in BDNF heterozygous mice.
Neuroreport. 15: 2665-8, 2004.
97)  Szapacs ME, Mathews TA, Tessarollo L, Ernest Lyons W, Mamounas LA, Andrews AM.
Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression.
J Neurosci Methods. 140: 81-92, 2004.
98)  Chiang YJ, Hemann MT, Hathcock KS, Tessarollo L, Feigenbaum L, Hahn WC, Hodes RJ.
Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo.
Mol. Cell. Biol. 24: 7024-31, 2004.
99)  Hisa T, Spence SE, Rachel RA, Fujita M, Nakamura T, Ward JM, Devor-Henneman DE, Saiki Y, Kutsuna H, Tessarollo L, Jenkins NA, Copeland NG.
Hematopoietic, angiogenic and eye defects in Meis1 mutant animals.
EMBO J. 23: 450-9, 2004.
100)  Halladay AK, Tessarollo L, Zhou R, Wagner GC.
Neurochemical and behavioral deficits consequent to expression of a dominant negative EphA5 receptor.
Brain Res. Mol. Brain Res. 123: 104-11, 2004.
101)  Fritzsch B, Tessarollo L, Coppola E, Reichardt LF.
Neurotrophins in the ear: their roles in sensory neuron survival and fiber guidance.
Prog Brain Res. 146: 265-278, 2004.
102)  Tessarollo L, Coppola V, Fritzsch B.
NT-3 replacement with brain-derived neurotrophic factor redirects vestibular nerve fibers to the cochlea.
J Neurosci. 24: 2575-84, 2004.
103)  Sedý J, Szeder V, Walro JM, Ren ZG, Nanka O, Tessarollo L, Sieber-Blum M, Grim M, Kucera J.
Pacinian corpuscle development involves multiple Trk signaling pathways.
Dev. Dyn. 231: 551-63, 2004.
104)  Chiang YJ, Kim SH, Tessarollo L, Campisi J, Hodes RJ.
Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway.
Mol. Cell. Biol. 24: 6631-4, 2004.
105)  Liu P, Keller JR, Ortiz M, Tessarollo L, Rachel RA, Nakamura T, Jenkins NA, Copeland NG.
Bcl11a is essential for normal lymphoid development.
Nat. Immunol. 4: 525-32, 2003.
106)  Berthet C, Aleem E, Coppola V, Tessarollo L, Kaldis P.
Cdk2 knockout mice are viable.
Curr. Biol. 13: 1775-85, 2003.
107)  Hu Z, Yue X, Shi G, Yue Y, Crockett DP, Blair-Flynn J, Reuhl K, Tessarollo L, Zhou R.
Corpus callosum deficiency in transgenic mice expressing a truncated ephrin-A receptor.
J. Neurosci. 23: 10963-70, 2003.
108)  Ma W, Tessarollo L, Hong SB, Baba M, Southon E, Back TC, Spence S, Lobe CG, Sharma N, Maher GW, Pack S, Vortmeyer AO, Guo C, Zbar B, Schmidt LS.
Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene.
Cancer Res. 63: 5320-8, 2003.
109)  Wolff L, Garin MT, Koller R, Bies J, Liao W, Malumbres M, Tessarollo L, Powell D, Perella C.
Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15(Ink4b)-deficient mice.
Oncogene. 22: 9265-74, 2003.
110)  Youn YH, Feng J, Tessarollo L, Ito K, Sieber-Blum M.
Neural crest stem cell and cardiac endothelium defects in the TrkC null mouse.
Mol. Cell. Neurosci. 24: 160-70, 2003.
111)  Kumaraswamy E, Carlson BA, Morgan F, Miyoshi K, Robinson GW, Su D, Wang S, Southon E, Tessarollo L, Lee BJ, Gladyshev VN, Hennighausen L, Hatfield DL.
Selective removal of the selenocysteine tRNA [Ser]Sec gene (Trsp) in mouse mammary epithelium.
Mol. Cell. Biol. 23: 1477-88, 2003.
112)  Akbarian S, Rios M, Liu RJ, Gold SJ, Fong HF, Zeiler S, Coppola V, Tessarollo L, Jones KR, Nestler EJ, Aghajanian GK, Jaenisch R.
Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons.
J Neurosci. 22: 4153-62, 2002.
113)  Lincoln AJ, Wickramasinghe D, Stein P, Schultz RM, Palko ME, De Miguel MP, Tessarollo L, Donovan PJ.
Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation.
Nat. Genet. 30: 446-9, 2002.
114)  Cobb S, Wood T, Tessarollo L, Velasco M, Given R, Varro A, Tarasova N, Singh P.
Deletion of functional gastrin gene markedly increases colon carcinogenesis in response to azoxymethane in mice.
Gastroenterology. 123: 516-30, 2002.
115)  Cronk KM, Wilkinson GA, Grimes R, Wheeler EF, Jhaveri S, Fundin BT, Silos-Santiago I, Tessarollo L, Reichardt LF, Rice FL.
Diverse dependencies of developing Merkel innervation on the trkA and both full-length and truncated isoforms of trkC.
Development. 129: 3739-50, 2002.
116)  Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen HT, Sedelnikova OA, Reina-San-Martin B, Coppola V, Meffre E, Difilippantonio MJ, Redon C, Pilch DR, Olaru A, Eckhaus M, Camerini-Otero RD, Tessarollo L, Livak F, Manova K, Bonner WM, Nussenzweig MC, Nussenzweig A.
Genomic instability in mice lacking histone H2AX.
Science. 296: 922-7, 2002.
117)  Bartoletti A, Cancedda L, Reid SW, Tessarollo L, Porciatti V, Pizzorusso T, Maffei L.
Heterozygous knock-out mice for brain-derived neurotrophic factor show a pathway-specific impairment of long-term potentiation but normal critical period for monocular deprivation.
J Neurosci. 22: 10072-7, 2002.
118)  Yue Y, Chen ZY, Gale NW, Blair-Flynn J, Hu TJ, Yue X, Cooper M, Crockett DP, Yancopoulos GD, Tessarollo L, Zhou R.
Mistargeting hippocampal axons by expression of a truncated Eph receptor.
Proc. Natl. Acad. Sci. U.S.A. 99: 10777-82, 2002.
119)  Steingrimsson E, Tessarollo L, Pathak B, Hou L, Arnheiter H, Copeland NG, Jenkins NA.
Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development.
Proc. Natl. Acad. Sci. U.S.A. 99: 4477-82, 2002.
120)  Wilson SM, Bhattacharyya B, Rachel RA, Coppola V, Tessarollo L, Householder DB, Fletcher CF, Miller RJ, Copeland NG, Jenkins NA.
Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease.
Nat. Genet. 32: 420-5, 2002.
121)  Fernández-Medarde A, Esteban LM, Núñez A, Porteros A, Tessarollo L, Santos E.
Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development.
Mol. Cell. Biol. 22: 2498-504, 2002.
122)  Cupp AS, Tessarollo L, Skinner MK.
Testis developmental phenotypes in neurotropin receptor trkA and trkC null mutations: role in formation of seminiferous cords and germ cell survival.
Biol Reprod. 66: 1838-45, 2002.
123)  Lee EC, Yu D, Martinez de Velasco J, Tessarollo L, Swing DA, Court DL, Jenkins NA, Copeland NG.
A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA.
Genomics. 73: 56-65, 2001.
124)  Bera TK, Bera J, Brinkmann U, Tessarollo L, Pastan I.
Cse1l is essential for early embryonic growth and development.
Mol. Cell. Biol. 21: 7020-4, 2001.
125)  Coppola V, Kucera J, Palko ME, Martinez-De Velasco J, Lyons WE, Fritzsch B, Tessarollo L.
Dissection of NT3 functions in vivo by gene replacement strategy.
Development. 128: 4315-27, 2001.
126)  Fletcher CF, Tottene A, Lennon VA, Wilson SM, Dubel SJ, Paylor R, Hosford DA, Tessarollo L, McEnery MW, Pietrobon D, Copeland NG, Jenkins NA.
Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity.
FASEB J. 15: 1288-90, 2001.
127)  Chandler J, Hohenstein P, Swing DA, Tessarollo L, Sharan SK.
Human BRCA1 gene rescues the embryonic lethality of Brca1 mutant mice.
Genesis. 29: 72-7, 2001.
128)  Collazo CM, Yap GS, Sempowski GD, Lusby KC, Tessarollo L, Woude GF, Sher A, Taylor GA.
Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection.
J. Exp. Med. 194: 181-8, 2001.
129)  Bonin A, Reid SW, Tessarollo L.
Isolation, microinjection, and transfer of mouse blastocysts.
Methods Mol. Biol. 158: 121-34, 2001.
130)  Geiman TM, Tessarollo L, Anver MR, Kopp JB, Ward JM, Muegge K.
Lsh, a SNF2 family member, is required for normal murine development.
Biochim. Biophys. Acta. 1526: 211-20, 2001.
131)  Tessarollo L.
Manipulating mouse embryonic stem cells.
Methods Mol Biol. 158: 47-63, 2001.
132)  Wilson SM, Householder DB, Coppola V, Tessarollo L, Fritzsch B, Lee EC, Goss D, Carlson GA, Copeland NG, Jenkins NA.
Mutations in Cdh23 cause nonsyndromic hearing loss in waltzer mice.
Genomics. 74: 228-33, 2001.
133)  Chalazonitis A, Pham TD, Rothman TP, DiStefano PS, Bothwell M, Blair-Flynn J, Tessarollo L, Gershon MD.
Neurotrophin-3 is required for the survival-differentiation of subsets of developing enteric neurons.
J. Neurosci. 21: 5620-36, 2001.
134)  Akbarian S, Bates B, Liu RJ, Skirboll SL, Pejchal T, Coppola V, Sun LD, Fan G, Kucera J, Wilson MA, Tessarollo L, Kosofsky BE, Taylor JR, Bothwell M, Nestler EJ, Aghajanian GK, Jaenisch R.
Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal.
Mol. Psychiatry. 6: 593-604, 2001.
135)  Fariñas I, Jones KR, Tessarollo L, Vigers AJ, Huang E, Kirstein M, de Caprona DC, Coppola V, Backus C, Reichardt LF, Fritzsch B.
Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression.
J. Neurosci. 21: 6170-80, 2001.
136)  Zhu J, Petersen S, Tessarollo L, Nussenzweig A.
Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.
Curr. Biol. 11: 105-9, 2001.
137)  Mamounas LA, Altar CA, Blue ME, Kaplan DR, Tessarollo L, Lyons WE.
BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain.
J Neurosci. 20: 771-82, 2000.
138)  Wong PC, Waggoner D, Subramaniam JR, Tessarollo L, Bartnikas TB, Culotta VC, Price DL, Rothstein J, Gitlin JD.
Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase.
Proc. Natl. Acad. Sci. U.S.A. 97: 2886-91, 2000.
139)  Liebl DJ, Klesse LJ, Tessarollo L, Wohlman T, Parada LF.
Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice.
Proc. Natl. Acad. Sci. U.S.A. 97: 2297-302, 2000.
140)  Taylor GA, Collazo CM, Yap GS, Nguyen K, Gregorio TA, Taylor LS, Eagleson B, Secrest L, Southon EA, Reid SW, Tessarollo L, Bray M, McVicar DW, Komschlies KL, Young HA, Biron CA, Sher A, Vande Woude GF.
Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP.
Proc. Natl. Acad. Sci. U.S.A. 97: 751-5, 2000.
141)  Esteban LM, Fernández-Medarde A, López E, Yienger K, Guerrero C, Ward JM, Tessarollo L, Santos E.
Ras-guanine nucleotide exchange factor sos2 is dispensable for mouse growth and development.
Mol. Cell. Biol. 20: 6410-3, 2000.
142)  Wilson SM, Toth PT, Oh SB, Gillard SE, Volsen S, Ren D, Philipson LH, Lee EC, Fletcher CF, Tessarollo L, Copeland NG, Jenkins NA, Miller RJ.
The status of voltage-dependent calcium channels in alpha 1E knock-out mice.
J. Neurosci. 20: 8566-71, 2000.
143)  Lyons WE, Mamounas LA, Ricaurte GA, Coppola V, Reid SW, Bora SH, Wihler C, Koliatsos VE, Tessarollo L.
Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities.
Proc. Natl. Acad. Sci. U.S.A. 96: 15239-44, 1999.
144)  Maier DL, Mani S, Donovan SL, Soppet D, Tessarollo L, McCasland JS, Meiri KF.
Disrupted cortical map and absence of cortical barrels in growth-associated protein (GAP)-43 knockout mice.
Proc. Natl. Acad. Sci. U.S.A. 96: 9397-402, 1999.
145)  Palko ME, Coppola V, Tessarollo L.
Evidence for a role of truncated trkC receptor isoforms in mouse development.
J. Neurosci. 19: 775-82, 1999.
146)  Kucera J, Fan G, Walro J, Copray S, Tessarollo L, Jaenisch R.
Neurotrophin-3 and trkC in muscle are non-essential for the development of mouse muscle spindles.
Neuroreport. 9: 905-9, 1998.
147)  Tessarollo L.
Pleiotropic functions of neurotrophins in development.
Cytokine Growth Factor Rev. 9: 125-37, 1998.
148)  Sterneck E, Paylor R, Jackson-Lewis V, Libbey M, Przedborski S, Tessarollo L, Crawley JN, Johnson PF.
Selectively enhanced contextual fear conditioning in mice lacking the transcriptional regulator CCAAT/enhancer binding protein delta.
Proc. Natl. Acad. Sci. U.S.A. 95: 10908-13, 1998.
149)  Steingrímsson E, Tessarollo L, Reid SW, Jenkins NA, Copeland NG.
The bHLH-Zip transcription factor Tfeb is essential for placental vascularization.
Development. 125: 4607-16, 1998.
150)  Liebl DJ, Tessarollo L, Palko ME, Parada LF.
Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice.
J. Neurosci. 17: 9113-21, 1997.
151)  Sterneck E, Tessarollo L, Johnson PF.
An essential role for C/EBPbeta in female reproduction.
Genes Dev. 11: 2153-62, 1997.
152)  Tessarollo L, Tsoulfas P, Donovan MJ, Palko ME, Blair-Flynn J, Hempstead BL, Parada LF.
Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis.
Proc. Natl. Acad. Sci. U.S.A. 94: 14776-81, 1997.
153)  Nelson CE, Morgan BA, Burke AC, Laufer E, DiMambro E, Murtaugh LC, Gonzales E, Tessarollo L, Parada LF, Tabin C.
Analysis of Hox gene expression in the chick limb bud.
Development. 122: 1449-66, 1996.
154)  Donovan MJ, Hahn R, Tessarollo L, Hempstead BL.
Identification of an essential nonneuronal function of neurotrophin 3 in mammalian cardiac development.
Nat. Genet. 14: 210-3, 1996.
155)  Choi T, Fukasawa K, Zhou R, Tessarollo L, Borror K, Resau J, Vande Woude GF.
The Mos/mitogen-activated protein kinase (MAPK) pathway regulates the size and degradation of the first polar body in maturing mouse oocytes.
Proc. Natl. Acad. Sci. U.S.A. 93: 7032-5, 1996.
156)  Tessarollo L, Parada LF.
In situ hybridization.
Meth. Enzymol. 254: 419-30, 1995.
157)  Donovan MJ, Miranda RC, Kraemer R, McCaffrey TA, Tessarollo L, Mahadeo D, Sharif S, Kaplan DR, Tsoulfas P, Parada L.
Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury.
Am. J. Pathol. 147: 309-24, 1995.
158)  Wickramasinghe D, Becker S, Ernst MK, Resnick JL, Centanni JM, Tessarollo L, Grabel LB, Donovan PJ.
Two CDC25 homologues are differentially expressed during mouse development.
Development. 121: 2047-56, 1995.
159)  Tessarollo L, Vogel KS, Palko ME, Reid SW, Parada LF.
Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons.
Proc. Natl. Acad. Sci. U.S.A. 91: 11844-8, 1994.
160)  Lindholm D, Castrén E, Tsoulfas P, Kolbeck R, Berzaghi Mda P, Leingärtner A, Heisenberg CP, Tessarollo L, Parada LF, Thoenen H, Tesarollo L.
Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation.
J. Cell Biol. 122: 443-50, 1993.
161)  Tsoulfas P, Soppet D, Escandon E, Tessarollo L, Mendoza-Ramirez JL, Rosenthal A, Nikolics K, Parada LF.
The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells.
Neuron. 10: 975-90, 1993.
162)  Tessarollo L, Tsoulfas P, Martin-Zanca D, Gilbert DJ, Jenkins NA, Copeland NG, Parada LF.
trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues.
Development. 118: 463-75, 1993.
163)  Stanton BR, Perkins AS, Tessarollo L, Sassoon DA, Parada LF.
Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop.
Genes Dev. 6: 2235-47, 1992.
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