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Our Science – Sharan Website

Shyam K. Sharan, Ph.D.

Selected Publications

1)  Biswas K, Das R, Eggington JM, Qiao H, North SL, Stauffer S, Burkett SS, Martin BK, Southon E, Sizemore SC, Pruss D, Bowles KR, Roa BB, Hunter N, Tessarollo L, Wenstrup RJ, Byrd RA, Sharan SK.
Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay.
Hum. Mol. Genet. 21: 3993-4006, 2012.
2)  Chang S, Wang RH, Akagi K, Kim KA, Martin BK, Cavallone L, Haines DC, Basik M, Mai P, Poggi E, Isaacs C, Looi LM, Mun KS, Greene MH, Byers SW, Teo SH, Deng CX, Sharan SK.
Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155.
Nat. Med. 17: 1275-82, 2011.
3)  Chang S, Biswas K, Martin BK, Stauffer S, Sharan SK.
Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations.
J. Clin. Invest. 119: 3160-71, 2009.
4)  Biswas K, Das R, Alter BP, Kuznetsov SG, Stauffer S, North SL, Burkett S, Brody LC, Meyer S, Byrd RA, Sharan SK.
A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay.
Blood. 118: 2430-42, 2011.
5)  Kuznetsov SG, Liu P, Sharan SK.
Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2.
Nat. Med. 14: 875-81, 2008.
6)  Bakker JL, Thirthagiri E, van Mil SE, Adank MA, Ikeda H, Verheul HM, Meijers-Heijboer H, de Winter JP, Sharan SK, Waisfisz Q.
A Novel Splice Site Mutation in the Non-coding Region of BRCA2: Implications for Fanconi Anemia and Familial Breast Cancer Diagnostics.
Hum. Mutat. 35: 442-6, 2014.
7)  Mukherjee M, Ge G, Zhang N, Edwards DG, Sumazin P, Sharan SK, Rao PH, Medina D, Pati D.
MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERa)-positive mammary adenocarcinomas.
Oncogene. [Epub ahead of print], 2013.
8)  Chang S, Sharan SK.
The role of epigenetic transcriptional regulation in BRCA1-mediated tumor suppression.
Transcription. 4: 24-28, 2013.
Full Text Article. [Journal]
9)  Chang S, Sharan SK.
BRCA1 and MicroRNAs: Emerging networks and potential therapeutic targets.
Mol. Cells. 34: 425-32, 2012.
10)  Sharan SK, Thomason LC, Kuznetsov SG, Court DL.
Recombineering: a homologous recombination-based method of genetic engineering.
Nat Protoc. 4: 206-23, 2009.
Click Here to View Expanded Bibliography.

This page was last updated on 6/18/2014.