Skip CCR Main Navigation National Cancer Institute National Cancer Institute U.S. National Institutes of Health www.cancer.gov
CCR - For Our Staff| Home |

Our Science – Le Grice Website

Stuart F.J. Le Grice, Ph.D.

Selected Publications

1)  Costi R, Métifiot M, Chung S, Cuzzucoli Crucitti G, Maddali K, Pescatori L, Messore A, Madia V, Pupo G, Scipione L, Tortorella S, Di Leva F, Cosconati S, Marinelli L, Novellino E, Le Grice S, Corona A, Pommier Y, Marchand C, Di Santo R.
Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.
J Med Chem. 2014.
In Press. [Journal]
2)  Nowak E, Miller J, Bona M, Studnicka J, Szczepanowski R, Jurkowski J, Le Grice S, Nowotny M.
Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry.
Nat. Struct. Mol. Biol. 21: 389-96, 2014.
[Journal]
3)  Abbondanzieri E, Le Grice S.
Unraveling the gymnastics of reverse transcription through single molecule spectroscopy.
AIDS Res Hum Retroviruses. 30: 209-210, 2014.
Full Text Article. [Journal]
4)  Fang X, Wang J, O'Carroll IP, Mitchell M, Zuo X, Wang Y, Yu P, Liu Y, Rausch JW, Dyba MA, Kjems J, Schwieters CD, Seifert S, Winans RE, Watts NR, Stahl SJ, Wingfield PT, Byrd RA, Le Grice SF, Rein A, Wang Y.
An Unusual Topological Structure of the HIV-1 Rev Response Element.
Cell. 155: 594-605, 2013.
Full Text Article. [Journal]
5)  Lusvarghi S, Sztuba-Solinska J, Purzycka KJ, Pauly GT, Rausch JW, Grice SF.
The HIV-2 Rev-response element: determining secondary structure and defining folding intermediates.
Nucleic Acids Res. 41: 6637-49, 2013.
[Journal]
6)  Sztuba-Solinska J, Teramoto T, Rausch JW, Shapiro BA, Padmanabhan R, Le Grice SF.
Structural complexity of Dengue virus untranslated regions: cis-acting RNA motifs and pseudoknot interactions modulating functionality of the viral genome.
Nucleic Acids Res. 41: 5075-89, 2013.
Full Text Article. [Journal]
7)  Lapkouski M, Tian L, Miller JT, Le Grice SF, Yang W.
Complexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradation.
Nat. Struct. Mol. Biol. 20: 230-6, 2013.
[Journal]
8)  Chamanian M, Purzycka KJ, Wille PT, Ha JS, McDonald D, Gao Y, Le Grice SF, Arts EJ.
A cis-Acting Element in Retroviral Genomic RNA Links Gag-Pol Ribosomal Frameshifting to Selective Viral RNA Encapsidation.
Cell Host Microbe. 13: 181-92, 2013.
[Journal]
9)  Lapkouski M, Tian L, Miller J, Le Grice S, Yang W.
Reply to “Structural requirements for RNA degradation by HIV-1 reverse transcriptase”.
Nat Struct Mol Biol. 20: 1342-1343, 2013.
Full Text Article. [Journal]
10)  Corona A, Masaoka T, Tocco G, Tramontano E, Le Grice SF.
Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase.
Future Med Chem. 5: 2127-39, 2013.
[Journal]
Click Here to View Expanded Bibliography.

This page was last updated on 4/7/2014.