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Our Science – Ruscetti Website

Sandra K. Ruscetti, Ph.D.

Selected Publications
1)  Macpherson GR, Hanson CA, Thompson DM, Perella CM, Cmarik JL, Ruscetti SK.
Retrovirus-transformed erythroleukemia cells induce central nervous system failure in a new syngeneic mouse model of meningeal leukemia.
Leuk. Res. 36: 369-76, 2012. [Journal]
2)  Umehara D, Kawamura M, Odahara Y, Watanabe S, Hanson C, Ruscetti S, Nishigaki K.
Role of N-terminal sequences of the tyrosine kinase sf-Stk in transformation of rodent fibroblasts by variants of Friend spleen focus-forming virus.
Int. J. Cancer. 131: 1083-94, 2012. [Journal]
3)  Ruscetti S, Cmarik J.
Dudley J, eds.
Deregulation of signal transduction pathways by oncogenic retroviruses. In: Retroviruses and Insights into Cancer.
New York: Springer; 2011. p. 53-94 [Book Chapter]
4)  Li X, Zhang X, Cmarik JL, Ruscetti S.
Importance of macrophage inflammatory protein-1α and splenic macrophages in neurodegeneration induced by PVC-211 murine leukemia virus.
Virology. 409: 198-203, 2011. [Journal]
5)  Cmarik JL, Troxler JA, Hanson CA, Zhang X, Ruscetti SK.
The human lung adenocarcinoma cell line EKVX produces an infectious xenotropic murine leukemia virus.
Viruses. 3: 2442-61, 2011. [Journal]
6)  Cmarik J, Ruscetti S.
Friend spleen focus-forming virus activates the tyrosine kinase sf-Stk and the transcription factor PU.1 to cause a multi-stage erythroleukemia in mice.
Viruses. 2: 2235-2257, 2010. [Journal]
7)  Umehara D, Watanabe S, Ochi H, Anai Y, Ahmed N, Kannagi M, Hanson C, Ruscetti S, Nishigaki K.
Role of Phosphatidylinositol 3-Kinase in Friend Spleen Focus-Forming Virus-Induced Disease.
J Virol. 84: 7675-7682, 2010. [Journal]
8)  Li X, Hanson C, Cmarik JL, Ruscetti S.
Neurodegeneration induced by PVC-211 murine leukemia virus is associated with increased levels of vascular endothelial growth factor and macrophage inflammatory protein 1 alpha and is inhibited by blocking activation of microglia.
J. Virol. 83: 4912-22, 2009. [Journal]
9)  Fan T, Schmidtmann A, Xi S, Briones V, Zhu H, Suh HC, Gooya J, Keller JR, Xu H, Roayaei J, Anver M, Ruscetti S, Muegge K.
DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development.
Epigenetics. 3: 134-42, 2008. [Journal]
10)  Jelacic TM, Thompson D, Hanson C, Cmarik JL, Nishigaki K, Ruscetti S.
The tyrosine kinase sf-Stk and its downstream signals are required for maintenance of friend spleen focus-forming virus-induced fibroblast transformation.
J. Virol. 82: 419-27, 2008. [Journal]
11)  Nishigaki K, Hanson C, Ohashi T, Spadaccini A, Ruscetti S.
Erythroblast transformation by the friend spleen focus-forming virus is associated with a block in erythropoietin-induced STAT1 phosphorylation and DNA binding and correlates with high expression of the hematopoietic phosphatase SHP-1.
J. Virol. 80: 5678-85, 2006. [Journal]
12)  Nishigaki K, Hanson C, Thompson D, Yugawa T, Ruscetti S.
Activation of the Jun N-terminal kinase pathway by Friend spleen focus-forming virus and its role in the growth and survival of Friend virus-induced erythroleukemia cells.
J. Virol. 79: 12752-12762, 2005. [Journal]
13)  Nishigaki K, Hanson C, Jelacic T, Thompson D, Ruscetti S.
Friend spleen focus-forming virus transforms rodent fibroblasts in cooperation with a short form of the receptor tyrosine kinase Stk.
Proc Natl Acad Sci U S A. 102: 15488-93, 2005. [Journal]
14)  Ruscetti SK.
Generation of mink cell focus-inducing retroviruses: a model for understanding how viral-viral and viral-cellular interactions can result in biological consequences.
Dev Biol (Basel). 106: 163-7; discussion 167-8, 253-63, 2001. [Journal]
15)  Yen CH, Yang YC, Ruscetti SK, Kirken RA, Dai RM, Li CC.
Involvement of the ubiquitin-proteasome pathway in the degradation of nontyrosine kinase-type cytokine receptors of IL-9, IL-2, and erythropoietin.
J. Immunol. 165: 6372-80, 2000. [Journal]
16)  Rulli K, Yugawa T, Hanson C, Thompson D, Ruscetti S, Nishigaki K.
Ex vivo and in vivo biological effects of a truncated form of the receptor tyrosine kinase Stk when activated by interaction with the Friend spleen focus-forming virus envelope glycoprotein or by point mutation.
J. Virol. 78: 4573-4581, 2004. [Journal]
17)  Nishigaki K, Thompson D, Yugawa T, Rulli K, Hanson C, Cmarik J, Gutkind JS, Teramoto H, Ruscetti S.
Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase.
J. Biol. Chem. 278: 13520-13530, 2003. [Journal]
18)  Jinno-Oue A, Wilt SG, Hanson C, Dugger NV, Hoffman PM, Masuda M, Ruscetti SK.
Expression of inducible nitric oxide synthase and elevation of tyrosine nitration of a 32-kilodalton cellular protein in brain capillary endothelial cells from rats infected with a neuropathogenic murine leukemia virus.
J. Virol. 77: 5145-5151, 2003. [Journal]
19)  Nishigaki K, Thompson D, Hanson C, Yugawa T, Ruscetti S.
The envelope glycoprotein of Friend spleen focus-forming virus covalently interacts with and constitutively activates a truncated form of the receptor tyrosine kinase Stk.
J Virol. 75: 7893-903, 2001. [Journal]
20)  Nishigaki K, Hanson C, Thompson D, Yugawa T, Hisasue M, Tsujimoto H, Ruscetti S.
Analysis of the disease potential of a recombinant retrovirus containing Friend murine leukemia viral sequences and a unique long terminal repeat from feline leukemia virus.
J. Virol. 76: 1527-1532, 2002. [Journal]
21)  Jinno-Oue A, Oue M, Ruscetti SK.
A unique heparin-binding domain in the envelope protein of the neuropathogenic PVC-211 murine leukemia virus may contribute to its brain capillary endothelial cell tropism.
J Virol. 75: 12439-12445, 2001. [Journal]
22)  Nishigaki K, Hanson C, Ohashi T, Thompson D, Muszynski K, Ruscetti S.
Erythroid cells rendered erythropoietin independent by infection with Friend spleen focus-forming virus show constitutive activation of phosphatidylinositol 3-kinase and Akt kinase: involvement of insulin receptor substrate-related adapter proteins.
J Virol. 74: 3037–45, 2000. [Journal]
23)  Muszynski KW, Thompson D, Hanson C, Lyons R, Spadaccini A, Ruscetti SK.
Growth factor-independent proliferation of erythroid cells infected with Friend spleen focus-forming virus is protein kinase C dependent but does not require Ras-GTP.
J Virol. 74: 8444–51, 2000. [Journal]
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This page was last updated on 4/29/2013.