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Our Science – Colburn Website

Nancy H. Colburn, Ph.D.

Selected Publications

1)  Saud SM, Young MR, Jones-Hall YL, Ileva L, Evbuomwan MO, Wise J, Colburn NH, Kim YS, Bobe G.
Chemopreventive Activity of Plant Flavonoid Isorhamnetin in Colorectal Cancer Is Mediated by Oncogenic Src and ß-Catenin.
Cancer Res. 73: 5473-5484, 2013.
2)  Wei Q, Jiang H, Baker A, Dodge LK, Gerard M, Young MR, Toledano MB, Colburn NH.
Loss of sulfiredoxin renders mice resistant to azoxymethane/dextran sulfate sodium-induced colon carcinogenesis.
Carcinogenesis. [Epub ahead of print], 2013.
3)  Camalier CE, Yi M, Yu L, Hood BL, Conrads KA, Lee YJ, Lin Y, Garneys LM, Bouloux GF, Young MR, Veenstra TD, Stephens RM, Colburn NH, Conrads TP, Beck GR.
An integrated understanding of the physiological response to elevated extracellular phosphate.
J. Cell. Physiol. [Epub ahead of print], 2012.
4)  Kim YS, Farrar W, Colburn NH, Milner JA.
Cancer stem cells: potential target for bioactive food components.
J. Nutr. Biochem. 23: 691-8, 2012.
5)  Blees JS, Bokesch HR, Rübsamen D, Schulz K, Milke L, Bajer MM, Gustafson KR, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.
Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase ß-TrCP1.
PLoS ONE. 7: e46567, 2012.
6)  Mitsunaga M, Kosaka N, Choyke PL, Young MR, Dextras CR, Saud SM, Colburn NH, Sakabe M, Nagano T, Asanuma D, Urano Y, Kobayashi H.
Fluorescence endoscopic detection of murine colitis-associated colon cancer by topically applied enzymatically rapid-activatable probe.
Gut. [Epub ahead of print], 2012.
7)  Mentor-Marcel RA, Bobe G, Sardo C, Wang L, Kuo C, Stoner G, Colburn NH.
Plasma Cytokines as Potential Response Indicators to Dietary Freeze-Dried Black Raspberries in Colorectal Cancer Patients.
Nutr Cancer. [Epub ahead of print], 2012.
8)  Narasimhan M, Rathinam M, Riar A, Patel D, Mummidi S, Yang H, Colburn NH, Henderson GI, Mahimainathan L.
Programmed Cell Death 4 (PDCD4): A Novel Player in Ethanol-Mediated Suppression of Protein Translation in Primary Cortical Neurons and Developing Cerebral Cortex.
Alcohol Clin Exp Res. [Epub ahead of print], 2012.
9)  Kang MI, Baker AR, Dextras CR, Cabarcas SM, Young MR, Colburn NH.
Targeting of Noncanonical Wnt5a Signaling by AP-1 Blocker Dominant-Negative Jun When It Inhibits Skin Carcinogenesis.
Genes Cancer. 3: 37-50, 2012.
10)  Zhang Z, Lanza E, Ross AC, Albert PS, Colburn NH, Rovine MJ, Bagshaw D, Ulbrecht JS, Hartman TJ.
A high-legume low-glycemic index diet reduces fasting plasma leptin in middle-aged insulin-resistant and -sensitive men.
Eur J Clin Nutr. 65: 415-8, 2011.
11)  Zhao LX, Huang SX, Tang SK, Jiang CL, Duan Y, Beutler JA, Henrich CJ, McMahon JB, Schmid T, Blees JS, Colburn NH, Rajski SR, Shen B.
Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600.
J. Nat. Prod. 74: 1990-5, 2011.
12)  Grkovic T, Blees JS, Colburn NH, Schmid T, Thomas CL, Henrich CJ, McMahon JB, Gustafson KR.
Cryptocaryols A-H, α-Pyrone-Containing 1,3-Polyols from Cryptocarya sp. Implicated in Stabilizing the Tumor Suppressor Pdcd4.
J. Nat. Prod. 74: 1015-20, 2011.
13)  Bobe G, Murphy G, Albert PS, Sansbury LB, Young MR, Lanza E, Schatzkin A, Colburn NH, Cross AJ.
Do interleukin polymorphisms play a role in the prevention of colorectal adenoma recurrence by dietary flavonols?.
Eur. J. Cancer Prev. 20: 86-95, 2011.
14)  Gaur AB, Holbeck SL, Colburn NH, Israel MA.
Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo.
Neuro-oncology. 13: 580-90, 2011.
15)  Popplewell WL, Ratnayake R, Wilson JA, Beutler JA, Colburn NH, Henrich CJ, McMahon JB, McKee TC.
Grassypeptolides F and G, Cyanobacterial Peptides from Lyngbya majuscula.
Journal of natural products. 2011.
16)  Schmid T, Bajer MM, Blees JS, Eifler LK, Milke L, Rübsamen D, Schulz K, Weigert A, Baker AR, Colburn NH, Brüne B.
Inflammation-induced loss of Pdcd4 is mediated by phosphorylation-dependent degradation.
Carcinogenesis. 2011.
17)  Devkota KP, Ratnayake R, Colburn NH, Wilson JA, Henrich CJ, McMahon JB, Beutler JA.
Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius.
J. Nat. Prod. 74: 374-7, 2011.
18)  Dong S, Cahill KJ, Kang MI, Colburn NH, Henrich CJ, Wilson JA, Beutler JA, Johnson RP, Porco JA.
Microwave-based reaction screening: tandem retro-Diels-Alder/Diels-Alder cycloadditions of o-quinol dimers.
J. Org. Chem. 76: 8944-54, 2011.
19)  Diyabalanage T, Ratnayake R, Wilson JA, Henrich CJ, Beutler JA, Colburn NH, McMahon JB, Gustafson KR.
Nothospondin, a new AP-1 inhibitory quassinoid from the Cameroonian plant Nothospondias staudtii.
Bioorg. Med. Chem. Lett. 21: 4397-9, 2011.
20)  Wei Q, Jiang H, Xiao Z, Baker A, Young MR, Veenstra TD, Colburn NH.
Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling.
Proc. Natl. Acad. Sci. U.S.A. 108: 7004-9, 2011.
21)  Tichelaar JW, Yan Y, Tan Q, Wang Y, Estensen RD, Young MR, Colburn NH, Yin H, Goodin C, Anderson MW, You M.
A Dominant-Negative c-jun Mutant Inhibits Lung Carcinogenesis in Mice.
Cancer prevention research (Philadelphia, Pa.). 2010.
22)  Zhang Z, Lanza E, Kris-Etherton PM, Colburn NH, Bagshaw D, Rovine MJ, Ulbrecht JS, Bobe G, Chapkin RS, Hartman TJ.
A High Legume Low Glycemic Index Diet Improves Serum Lipid Profiles in Men.
Lipids. 2010.
23)  Hartman TJ, Albert PS, Zhang Z, Bagshaw D, Kris-Etherton PM, Ulbrecht J, Miller CK, Bobe G, Colburn NH, Lanza E.
Consumption of a legume-enriched, low-glycemic index diet is associated with biomarkers of insulin resistance and inflammation among men at risk for colorectal cancer.
J. Nutr. 140: 60-7, 2010.
24)  Blees JS, Schmid T, Thomas CL, Baker AR, Benson L, Evans JR, Goncharova EI, Colburn NH, McMahon JB, Henrich CJ.
Development of a high-throughput cell-based reporter assay to identify stabilizers of tumor suppressor Pdcd4.
J Biomol Screen. 15: 21-9, 2010.
25)  Yasuda M, Schmid T, Rübsamen D, Colburn NH, Irie K, Murakami A.
Downregulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment.
Mol. Carcinog. 49: 837-48, 2010.
26)  Camalier CE, Young MR, Bobe G, Perella CM, Colburn NH, Beck GR.
Elevated phosphate activates N-ras and promotes cell transformation and skin tumorigenesis.
Cancer Prev Res (Phila Pa). 3: 359-70, 2010.
27)  Young MR, Santhanam AN, Yoshikawa N, Colburn NH.
Have tumor suppressor PDCD4 and its counteragent oncogenic miR-21 gone rogue?.
Mol. Interv. 10: 76-9, 2010.
28)  Bobe G, Albert PS, Sansbury LB, Lanza E, Schatzkin A, Colburn NH, Cross AJ.
Interleukin-6 as a potential indicator for prevention of high-risk adenoma recurrence by dietary flavonols in the polyp prevention trial.
Cancer Prev Res (Phila Pa). 3: 764-75, 2010.
29)  Santhanam AN, Baker AR, Hegamyer G, Kirschmann DA, Colburn NH.
Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion.
Oncogene. 29: 3921-32, 2010.
30)  Bobe G, Murphy G, Albert PS, Sansbury LB, Lanza E, Schatzkin A, Colburn NH, Cross AJ.
Serum cytokine concentrations, flavonol intake and colorectal adenoma recurrence in the Polyp Prevention Trial.
Br. J. Cancer. 103: 1453-61, 2010.
31)  Gamero AM, Young MR, Mentor-Marcel R, Bobe G, Scarzello AJ, Wise J, Colburn NH.
STAT2 contributes to promotion of colorectal and skin carcinogenesis.
Cancer Prev Res (Phila Pa). 3: 495-504, 2010.
32)  Kang MI, Henrich CJ, Bokesch HR, Gustafson KR, McMahon JB, Baker AR, Young MR, Colburn NH.
A selective small-molecule nuclear factor-kappaB inhibitor from a high-throughput cell-based assay for.
Mol. Cancer Ther. 8: 571-81, 2009.
33)  Kim YS, Young MR, Bobe G, Colburn NH, Milner JA.
Bioactive food components, inflammatory targets, and cancer prevention.
Cancer prevention research (Philadelphia, Pa.). 2: 200-8, 2009.
34)  Mentor-Marcel RA, Bobe G, Barrett KG, Young MR, Albert PS, Bennink MR, Lanza E, Colburn NH.
Inflammation-associated serum and colon markers as indicators of dietary attenuation of colon carcinogenesis in ob/ob mice.
Cancer prevention research (Philadelphia, Pa.). 2: 60-9, 2009.
35)  Yin Y, Wang S, Sun Y, Matt Y, Colburn NH, Shu Y, Han X.
JNK/AP-1 pathway is involved in tumor necrosis factor-alpha induced expression of vascular endothelial growth factor in MCF7 cells.
Biomed. Pharmacother. 63: 429-35, 2009.
36)  Yasuda M, Nishizawa T, Ohigashi H, Tanaka T, Hou DX, Colburn NH, Murakami A.
Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: Possible roles of programmed cell death 4 induction.
Carcinogenesis. 2009.
37)  Young MR, Ileva LV, Bernardo M, Riffle LA, Jones YL, Kim YS, Colburn NH, Choyke PL.
Monitoring of tumor promotion and progression in a mouse model of inflammation-induced colon cancer with magnetic resonance colonography.
Neoplasia. 11: 237-46, 1p following 246, 2009.
38)  Kitagaki J, Yang Y, Saavedra JE, Colburn NH, Keefer LK, Perantoni AO.
Nitric oxide prodrug JS-K inhibits ubiquitin E1 and kills tumor cells retaining wild-type p53.
Oncogene. 28: 619-24, 2009.
39)  Zhao C, Ivanov I, Dougherty ER, Hartman TJ, Lanza E, Bobe G, Colburn NH, Lupton JR, Davidson LA, Chapkin RS.
Noninvasive detection of candidate molecular biomarkers in subjects with a history of insulin resistance and colorectal adenomas.
Cancer prevention research (Philadelphia, Pa.). 2: 590-7, 2009.
40)  Beutler JA, Kang MI, Robert F, Clement JA, Pelletier J, Colburn NH, McKee TC, Goncharova E, McMahon JB, Henrich CJ.
Quassinoid Inhibition of AP-1 Function Does Not Correlate with Cytotoxicity or Protein Synthesis Inhibition (dagger).
J. Nat. Prod. 2009.
41)  Santhanam AN, Bindewald E, Rajasekhar VK, Larsson O, Sonenberg N, Colburn NH, Shapiro BA.
Role of 3'UTRs in the translation of mRNAs regulated by oncogenic eIF4E--a computational inference.
PLoS ONE. 4: e4868, 2009.
42)  Duan D, Sigano DM, Kelley JA, Lai CC, Lewin NE, Kedei N, Peach ML, Lee J, Abeyweera TP, Rotenberg SA, Kim H, Kim YH, Kazzouli SE, Chung JU, Young HA, Young MR, Baker A, Colburn NH, Haimovitz-Friedman A, Truman JP, Parrish DA, Deschamps JR, Perry NA, Surawski RJ, Blumberg PM, Marquez VE.
Conformationally Constrained Analogues of Diacylglycerol. 29. Cells Sort Diacylglycerol-Lactone Chemical Zip Codes to Produce Diverse and Selective Biological Activities.
J. Med. Chem. 2008.
43)  Wei Q, Jiang H, Matthews CP, Colburn NH.
Sulfiredoxin is an AP-1 target gene that is required for transformation and shows elevated expression in human skin malignancies.
Proc. Natl. Acad. Sci. U.S.A. 105: 19738-43, 2008.
44)  Shen Q, Uray IP, Li Y, Zhang Y, Hill J, Xu XC, Young MR, Gunther EJ, Hilsenbeck SG, Colburn NH, Chodosh LA, Brown PH.
Targeting the activator protein 1 transcription factor for the prevention of estrogen receptor-negative mammary tumors.
Cancer prevention research (Philadelphia, Pa.). 1: 45-55, 2008.
45)  Colburn NH, Kensler TW.
Targeting transcription factors for cancer prevention--the case of Nrf2.
Cancer prevention research (Philadelphia, Pa.). 1: 153-5, 2008.
46)  Abate-Shen C, Brown PH, Colburn NH, Gerner EW, Green JE, Lipkin M, Nelson WG, Threadgill D.
The untapped potential of genetically engineered mouse models in chemoprevention research: opportunities and challenges.
Cancer prevention research (Philadelphia, Pa.). 1: 161-6, 2008.
47)  Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY.
Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.
Biochem. Biophys. Res. Commun. 337: 1308-18, 2005.
48)  Hu J, Haseebuddin M, Young M, Colburn NH.
Suppression of p65 phosphorylation coincides with inhibition of IkappaBalpha polyubiquitination and degradation.
Mol. Carcinog. 44: 274-84, 2005.
49)  Kim HW, Park IK, Cho CS, Lee KH, Beck GR, Colburn NH, Cho MH.
Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice.
Cancer Res. 64: 7971-6, 2004.
50)  Davis MA, Flaws JA, Young M, Collins K, Colburn NH.
Effect of ceramide on intracellular glutathione determines apoptotic or necrotic cell death of JB6 tumor cells.
Toxicol. Sci. 53: 48-55, 2000.
51)  Li JJ, Cao Y, Young MR, Colburn NH.
Induced expression of dominant-negative c-jun downregulates NFkappaB and AP-1 target genes and suppresses tumor phenotype in human keratinocytes.
Mol. Carcinog. 29: 159-69, 2000.
52)  Bobe G, Barrett KG, Mentor-Marcel RA, Saffiotti U, Young MR, Colburn NH, Albert PS, Bennink MR, Lanza E.
Dietary cooked navy beans and their fractions attenuate colon carcinogenesis in azoxymethane-induced ob/ob mice.
Nutrition and cancer. 60: 373-81, 2008.
53)  Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S, Allgayer H.
MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer.
Oncogene. 27: 2128-36, 2008.
54)  Lu Z, Liu M, Stribinskis V, Klinge CM, Ramos KS, Colburn NH, Li Y.
MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene.
Oncogene. 27: 4373-9, 2008.
55)  Nieves-Alicea R, Colburn NH, Simeone A, Tari AM.
Programmed Cell Death 4 inhibits breast cancer cell invasion by increasing Tissue Inhibitor of Metalloproteinases-2 expression.
Breast Cancer Res. Treat. Epub ahead of print, 2008.
56)  Song C, Xiao Z, Nagashima K, Li CC, Lockett SJ, Dai RM, Cho EH, Conrads TP, Veenstra TD, Colburn NH, Wang Q, Wang JM.
The heavy metal cadmium induces valosin-containing protein (VCP)-mediated aggresome formation.
Toxicol. Appl. Pharmacol. 228: 351-63, 2008.
57)  Schmid T, Jansen AP, Baker AR, Hegamyer G, Hagan JP, Colburn NH.
Translation inhibitor Pdcd4 is targeted for degradation during tumor promotion.
Cancer Res. 68: 1254-60, 2008.
58)  Ruocco KM, Goncharova EI, Young MR, Colburn NH, McMahon JB, Henrich CJ.
A high-throughput cell-based assay to identify specific inhibitors of transcription factor AP-1.
J Biomol Screen. 12: 133-9, 2007.
59)  Hwang SK, Jin H, Kwon JT, Chang SH, Kim TH, Cho CS, Lee KH, Young MR, Colburn NH, Beck GR, Yang HS, Cho MH.
Aerosol-delivered programmed cell death 4 enhanced apoptosis, controlled cell cycle and suppressed AP-1 activity in the lungs of AP-1 luciferase reporter mice.
Gene Ther. 14: 1353-61, 2007.
60)  Matthews CP, Colburn NH, Young MR.
AP-1 a target for cancer prevention.
Curr Cancer Drug Targets. 7: 317-24, 2007.
61)  Matthews CP, Birkholz AM, Baker AR, Perella CM, Beck GR, Young MR, Colburn NH.
Dominant-negative activator protein 1 (TAM67) targets cyclooxygenase-2 and osteopontin under conditions in which it specifically inhibits tumorigenesis.
Cancer Res. 67: 2430-8, 2007.
62)  Mudduluru G, Medved F, Grobholz R, Jost C, Gruber A, Leupold JH, Post S, Jansen A, Colburn NH, Allgayer H.
Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer.
Cancer. 110: 1697-707, 2007.
63)  Ozpolat B, Akar U, Steiner M, Zorrilla-Calancha I, Tirado-Gomez M, Colburn N, Danilenko M, Kornblau S, Berestein GL.
Programmed cell death-4 tumor suppressor protein contributes to retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cells.
Mol. Cancer Res. 5: 95-108, 2007.
64)  LaRonde-LeBlanc N, Santhanam AN, Baker AR, Wlodawer A, Colburn NH.
Structural basis for inhibition of translation by the tumor suppressor Pdcd4.
Mol. Cell. Biol. 27: 147-56, 2007.
65)  Leupold JH, Yang HS, Colburn NH, Asangani I, Post S, Allgayer H.
Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors.
Oncogene. 26: 4550-62, 2007.
66)  Jin H, Kim TH, Hwang SK, Chang SH, Kim HW, Anderson HK, Lee HW, Lee KH, Colburn NH, Yang HS, Cho MH, Cho CS.
Aerosol delivery of urocanic acid-modified chitosan/programmed cell death 4 complex regulated apoptosis, cell cycle, and angiogenesis in lungs of K-ras null mice.
Mol. Cancer Ther. 5: 1041-9, 2006.
67)  Chang S, Yu KN, Lee Y, An G, Beck Jr GR, Colburn NH, Lee K, Cho M.
Elevated Inorganic Phosphate Stimulates AKT-ERK1/2-Mnk1 Signaling in Human Lung Cells.
Am J Respir Cell Mol Biol. 35: 528-39, 2006.
Full Text Article. [Journal]
68)  Young MR, Colburn NH.
Fra-1 a target for cancer prevention or intervention.
Gene. 379: 1-11, 2006.
69)  Dorrello NV, Peschiaroli A, Guardavaccaro D, Colburn NH, Sherman NE, Pagano M.
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.
Science. 314: 467-71, 2006.
70)  Shen Q, Zhang Y, Uray IP, Hill JL, Kim H, Lu C, Young MR, Gunther EJ, Hilsenbeck SG, Chodosh LA, Colburn NH, Brown PH.
The AP-1 transcription factor regulates postnatal mammary gland development.
Dev Biol. 295: 589-603, 2006.
Full Text Article. [Journal]
71)  Yang HS, Matthews CP, Clair T, Wang Q, Baker AR, Li CC, Tan TH, Colburn NH.
Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion.
Mol. Cell. Biol. 26: 1297-306, 2006.
72)  Weber TJ, Siegel RW, Markillie LM, Chrisler WB, Lei XC, Colburn NH.
A paracrine signal mediates the cell transformation response to low dose gamma radiation in JB6 cells.
Mol Carcinog. 43: 31-7, 2005.
73)  Jansen AP, Camalier CE, Colburn NH.
Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis.
Cancer Res. 65: 6034-41, 2005.
74)  Hu J, Colburn NH.
Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA binding.
Mol Cancer Res. 3: 100-9, 2005.
75)  Zakowicz H, Yang HS, Stark C, Wlodawer A, Laronde-Leblanc N, Colburn NH.
Mutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI.
RNA. 11: 261-74, 2005.
76)  Zhao Y, Chaiswing L, Velez JM, Batinic-Haberle I, Colburn NH, Oberley TD, St Clair DK.
p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase.
Cancer Res. 65: 3745-50, 2005.
77)  Yang HS, Cho MH, Zakowicz H, Hegamyer G, Sonenberg N, Colburn NH.
A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A.
Mol Cell Biol. 24: 3894-906, 2004.
78)  Hou DX, Kai K, Li JJ, Lin S, Terahara N, Wakamatsu M, Fujii M, Young MR, Colburn N.
Anthocyanidins inhibit activator protein 1 activity and cell transformation: structure-activity relationship and molecular mechanisms.
Carcinogenesis. 25: 29-36, 2004.
79)  Jansen AP, Camalier CE, Stark C, Colburn NH.
Characterization of programmed cell death 4 in multiple human cancers reveals a novel enhancer of drug sensitivity.
Mol Cancer Ther. 3: 103-10, 2004.
80)  Dhar A, Hu J, Reeves R, Resar LM, Colburn NH.
Dominant-negative c-Jun (TAM67) target genes: HMGA1 is required for tumor promoter-induced transformation.
Oncogene. 23: 4466-76, 2004.
81)  Hu J, Nakano H, Sakurai H, Colburn NH.
Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-{kappa}B activation and transformation in resistant JB6 cells.
Carcinogenesis. 25: 1991-2003, 2004.
82)  Cooper SJ, MacGowan J, Ranger-Moore J, Young MR, Colburn NH, Bowden GT.
Expression of dominant negative c-jun inhibits ultraviolet B-induced squamous cell carcinoma number and size in an SKH-1 hairless mouse model.
Mol Cancer Res. 1: 848-54, 2003.
83)  Dhar A, Brindley JM, Stark C, Citro ML, Keefer LK, Colburn NH.
Nitric oxide does not mediate but inhibits transformation and tumor phenotype.
Mol Cancer Ther. 2: 1285-93, 2003.
84)  Yang HS, Knies JL, Stark C, Colburn NH.
Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation.
Oncogene. 22: 3712-20, 2003.
85)  Young MR, Yang HS, Colburn NH.
Promising molecular targets for cancer prevention: AP-1, NF-kappa B and Pdcd4.
Trends Mol Med. 9: 36-41, 2003.
86)  Yang HS, Jansen AP, Komar AA, Zheng X, Merrick WC, Costes S, Lockett SJ, Sonenberg N, Colburn NH.
The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation.
Mol Cell Biol. 23: 26-37, 2003.
87)  Yang HS, Jansen AP, Komar AA, Zheng X, Merrick WC, Costes S, Lockett SJ, Sonenberg N, Colburn NH.
The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation.
Mol Cell Biol. 23: 26-37, 2003.
88)  Thompson EJ, MacGowan J, Young MR, Colburn N, Bowden GT.
A dominant negative c-jun specifically blocks okadaic acid-induced skin tumor promotion.
Cancer Res. 62: 3044-7, 2002.
89)  Shimamura T, Hsu TC, Colburn NH, Bejcek BE.
Activation of NF-kappaB is required for PDGF-B chain to transform NIH3T3 cells.
Exp Cell Res. 274: 157-67, 2002.
90)  Suzukawa K, Colburn NH.
AP-1 transrepressing retinoic acid does not deplete coactivators or AP-1 monomers but may target specific Jun or Fos containing dimers.
Oncogene. 21: 2181-90, 2002.
91)  Suzukawa K, Weber TJ, Colburn NH.
AP-1, NF-kappa-B, and ERK activation thresholds for promotion of neoplastic transformation in the mouse epidermal JB6 model.
Environ Health Perspect. 110: 865-70, 2002.
92)  Willis DB, Colburn NH.
Molecular targets for cancer prevention: a meeting review of the third American Cancer Society-Schilling Research Conference.
Cancer Epidemiol Biomarkers Prev. 11: 972-8, 2002.
93)  Young MR, Farrell L, Lambert P, Awasthi P, Colburn NH.
Protection against human papillomavirus type 16-E7 oncogene-induced tumorigenesis by in vivo expression of dominant-negative c-jun.
Mol Carcinog. 34: 72-7, 2002.
94)  Yu CY, Wang L, Khaletskiy A, Farrar WL, Larner A, Colburn NH, Li JJ.
STAT3 activation is required for interleukin-6 induced transformation in tumor-promotion sensitive mouse skin epithelial cells.
Oncogene. 21: 3949-60, 2002.
95)  Dhar A, Young MR, Colburn NH.
The role of AP-1, NF-kappaB and ROS/NOS in skin carcinogenesis: the JB6 model is predictive.
Mol Cell Biochem. 234-235: 185-93, 2002.
96)  Young MR, Nair R, Bucheimer N, Tulsian P, Brown N, Chapp C, Hsu TC, Colburn NH.
Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently.
Mol Cell Biol. 22: 587-98, 2002.
97)  Yang HS, Jansen AP, Nair R, Shibahara K, Verma AK, Cmarik JL, Colburn NH.
A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-kappaB or ODC transactivation.
Oncogene. 20: 669-76, 2001.
98)  Hsu TC, Nair R, Tulsian P, Camalier CE, Hegamyer GA, Young MR, Colburn NH.
Transformation nonresponsive cells owe their resistance to lack of p65/nuclear factor-kappaB activation.
Cancer Res. 61: 4160-8, 2001.
99)  Hsu TC, Young MR, Cmarik J, Colburn NH.
Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis.
Free Radic Biol Med. 28: 1338-48, 2000.
100)  Cmarik JL, Hegamyer G, Gerrard B, Dean M, Colburn NH.
cDNA cloning and mapping of mouse pleckstrin (Plek), a gene upregulated in transformation-resistant cells.
Genomics. 66: 204-12, 2000.
101)  Cmarik JL, Min H, Hegamyer G, Zhan S, Kulesz-Martin M, Yoshinaga H, Matsuhashi S, Colburn NH.
Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation.
Proc Natl Acad Sci U S A. 96: 14037-42, 1999.
102)  Young MR, Li JJ, Rincón M, Flavell RA, Sathyanarayana BK, Hunziker R, Colburn N.
Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion.
Proc Natl Acad Sci U S A. 96: 9827-32, 1999.
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This page was last updated on 9/11/2013.